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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for TFAP4_MSC

Z-value: 0.95

Motif logo

Transcription factors associated with TFAP4_MSC

Gene Symbol Gene ID Gene Info
ENSG00000090447.12 transcription factor AP-4
ENSG00000178860.9 musculin

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSChg38_v1_chr8_-_71844402_718444290.821.3e-02Click!
TFAP4hg38_v1_chr16_-_4273014_4273065-0.667.8e-02Click!

Activity profile of TFAP4_MSC motif

Sorted Z-values of TFAP4_MSC motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_55722857 1.15 ENST00000424486.3
transmembrane protein 100
chr13_+_101452629 0.98 ENST00000622834.4
ENST00000545560.6
ENST00000376180.8
integrin subunit beta like 1
chr11_-_111912871 0.96 ENST00000528628.5
crystallin alpha B
chr13_+_101452569 0.94 ENST00000618057.4
integrin subunit beta like 1
chr5_+_176810552 0.92 ENST00000329542.9
unc-5 netrin receptor A
chr2_-_224947030 0.92 ENST00000409592.7
dedicator of cytokinesis 10
chr20_+_34704336 0.89 ENST00000374809.6
ENST00000374810.8
ENST00000451665.5
tumor protein p53 inducible nuclear protein 2
chr6_-_31729260 0.86 ENST00000375789.7
dimethylarginine dimethylaminohydrolase 2
chr6_-_31729785 0.81 ENST00000416410.6
dimethylarginine dimethylaminohydrolase 2
chr8_-_94949350 0.79 ENST00000448464.6
ENST00000342697.5
tumor protein p53 inducible nuclear protein 1
chr6_-_31729478 0.78 ENST00000436437.2
dimethylarginine dimethylaminohydrolase 2
chrX_-_107775951 0.74 ENST00000315660.8
ENST00000372384.6
ENST00000502650.1
ENST00000506724.1
TSC22 domain family member 3
chr5_+_95731300 0.72 ENST00000379982.8
Rho related BTB domain containing 3
chr17_-_7241787 0.59 ENST00000577035.5
GABA type A receptor-associated protein
chr9_-_120477354 0.58 ENST00000416449.5
CDK5 regulatory subunit associated protein 2
chr2_-_213151590 0.54 ENST00000374319.8
ENST00000457361.5
ENST00000451136.6
ENST00000434687.6
IKAROS family zinc finger 2
chr19_+_18097763 0.53 ENST00000262811.10
microtubule associated serine/threonine kinase 3
chr1_-_33182030 0.52 ENST00000291416.10
tripartite motif containing 62
chr8_-_71362054 0.51 ENST00000340726.8
EYA transcriptional coactivator and phosphatase 1
chr11_-_70662197 0.51 ENST00000409161.5
SH3 and multiple ankyrin repeat domains 2
chr8_-_71361860 0.50 ENST00000303824.11
ENST00000645451.1
EYA transcriptional coactivator and phosphatase 1
chr6_-_31728877 0.50 ENST00000437288.5
dimethylarginine dimethylaminohydrolase 2
chr2_+_148021404 0.50 ENST00000638043.2
methyl-CpG binding domain protein 5
chr8_-_13276491 0.48 ENST00000512044.6
DLC1 Rho GTPase activating protein
chr11_-_70661762 0.48 ENST00000357171.7
ENST00000412252.5
ENST00000449833.6
ENST00000338508.8
SH3 and multiple ankyrin repeat domains 2
chr2_-_174764407 0.46 ENST00000409219.5
ENST00000409542.5
cholinergic receptor nicotinic alpha 1 subunit
chr12_-_53727428 0.46 ENST00000548263.5
ENST00000430117.6
ENST00000549173.5
ENST00000550804.6
ENST00000551900.5
ENST00000546619.5
ENST00000548177.5
ENST00000549349.5
calcium binding and coiled-coil domain 1
chr15_-_52652031 0.46 ENST00000546305.6
family with sequence similarity 214 member A
chr17_-_55732074 0.45 ENST00000575734.5
transmembrane protein 100
chr12_-_53727476 0.45 ENST00000549784.5
ENST00000262059.8
calcium binding and coiled-coil domain 1
chr6_-_117425905 0.44 ENST00000368507.8
ROS proto-oncogene 1, receptor tyrosine kinase
chr6_-_117425855 0.44 ENST00000368508.7
ROS proto-oncogene 1, receptor tyrosine kinase
chr11_-_1763894 0.44 ENST00000637915.1
ENST00000637815.2
ENST00000236671.7
ENST00000636571.1
ENST00000438213.6
ENST00000637387.1
ENST00000636843.1
ENST00000636397.1
ENST00000636615.1
cathepsin D
novel protein
chr13_-_42992165 0.43 ENST00000398762.7
ENST00000313640.11
ENST00000313624.12
epithelial stromal interaction 1
chr22_+_30607145 0.43 ENST00000405742.7
transcobalamin 2
chr7_-_137846860 0.43 ENST00000288490.9
ENST00000614521.2
ENST00000424189.6
ENST00000446122.5
diacylglycerol kinase iota
chr22_+_30607072 0.42 ENST00000450638.5
transcobalamin 2
chr22_+_30607167 0.41 ENST00000215838.8
transcobalamin 2
chr1_-_162023632 0.41 ENST00000367940.2
olfactomedin like 2B
chr13_-_33285682 0.40 ENST00000336934.10
StAR related lipid transfer domain containing 13
chr4_-_88697810 0.40 ENST00000323061.7
nucleosome assembly protein 1 like 5
chr6_+_155149109 0.40 ENST00000456877.6
ENST00000528391.6
TIAM Rac1 associated GEF 2
chr1_+_222928415 0.39 ENST00000284476.7
dispatched RND transporter family member 1
chr9_-_101594995 0.39 ENST00000636434.1
protein phosphatase 3 regulatory subunit B, beta
chr22_+_35381086 0.39 ENST00000216117.9
ENST00000677931.1
ENST00000679074.1
heme oxygenase 1
chr6_-_24910695 0.38 ENST00000643623.1
ENST00000538035.6
ENST00000647136.1
RHO family interacting cell polarization regulator 2
chr9_-_86947496 0.38 ENST00000298743.9
growth arrest specific 1
chr1_-_41918666 0.36 ENST00000372584.5
HIVEP zinc finger 3
chr4_+_85778681 0.36 ENST00000395183.6
Rho GTPase activating protein 24
chr2_+_30147516 0.36 ENST00000402708.5
yippee like 5
chr12_-_55842950 0.36 ENST00000548629.5
matrix metallopeptidase 19
chrX_+_9912434 0.36 ENST00000418909.6
shroom family member 2
chr2_-_175005357 0.35 ENST00000409156.7
ENST00000444573.2
ENST00000409900.9
chimerin 1
chr2_-_127643212 0.35 ENST00000409286.5
LIM zinc finger domain containing 2
chr20_+_64066211 0.35 ENST00000458442.1
transcription elongation factor A2
chr5_-_173328407 0.35 ENST00000265087.9
stanniocalcin 2
chr1_-_41918858 0.34 ENST00000372583.6
HIVEP zinc finger 3
chr10_-_62816309 0.34 ENST00000411732.3
early growth response 2
chr22_+_30607203 0.34 ENST00000407817.3
transcobalamin 2
chr10_-_62816341 0.33 ENST00000242480.4
ENST00000637191.1
early growth response 2
chr14_+_24115299 0.33 ENST00000559354.5
ENST00000560459.5
ENST00000559593.5
ENST00000396941.8
ENST00000396936.5
DDB1 and CUL4 associated factor 11
chr1_-_85578345 0.33 ENST00000426972.8
dimethylarginine dimethylaminohydrolase 1
chr12_-_108339300 0.32 ENST00000550402.6
ENST00000552995.5
ENST00000312143.11
chemerin chemokine-like receptor 1
chrX_-_107775740 0.31 ENST00000372383.9
TSC22 domain family member 3
chr7_-_28958321 0.31 ENST00000539664.3
TLR4 interactor with leucine rich repeats
chr1_-_16978276 0.31 ENST00000375534.7
microfibril associated protein 2
chr11_+_33039996 0.30 ENST00000432887.5
ENST00000528898.1
ENST00000531632.6
t-complex 11 like 1
chr16_-_31094549 0.29 ENST00000394971.7
vitamin K epoxide reductase complex subunit 1
chr2_+_148021083 0.28 ENST00000642680.2
methyl-CpG binding domain protein 5
chr13_+_31945826 0.28 ENST00000647500.1
FRY microtubule binding protein
chr16_-_31094727 0.28 ENST00000300851.10
ENST00000394975.3
vitamin K epoxide reductase complex subunit 1
chr2_+_148021001 0.27 ENST00000407073.5
methyl-CpG binding domain protein 5
chr17_+_60677822 0.27 ENST00000407086.8
ENST00000589222.5
ENST00000626960.2
ENST00000390652.9
BCAS3 microtubule associated cell migration factor
chr16_-_31094890 0.27 ENST00000532364.1
ENST00000529564.1
ENST00000319788.11
ENST00000354895.4
novel protein, VKORC1 and PRSS53 readthrough
vitamin K epoxide reductase complex subunit 1
chr2_+_94871419 0.27 ENST00000295201.5
tektin 4
chr2_-_224982420 0.27 ENST00000645028.1
dedicator of cytokinesis 10
chrX_-_102142461 0.26 ENST00000372774.7
transcription elongation factor A like 6
chr20_+_36091409 0.25 ENST00000202028.9
erythrocyte membrane protein band 4.1 like 1
chr9_+_128411715 0.25 ENST00000420034.5
ENST00000372842.5
cerebral endothelial cell adhesion molecule
chr19_-_45782388 0.25 ENST00000458663.6
DM1 protein kinase
chr1_+_159780930 0.25 ENST00000368109.5
ENST00000368108.7
ENST00000368107.2
dual specificity phosphatase 23
chr2_+_33476640 0.25 ENST00000425210.5
ENST00000444784.5
ENST00000423159.5
ENST00000403687.8
RAS guanyl releasing protein 3
chr11_+_45896541 0.25 ENST00000395629.2
mitogen-activated protein kinase 8 interacting protein 1
chr6_-_24911029 0.24 ENST00000259698.9
ENST00000644621.1
ENST00000644411.1
RHO family interacting cell polarization regulator 2
chr14_-_73027117 0.24 ENST00000318876.9
zinc finger FYVE-type containing 1
chr14_-_73027077 0.24 ENST00000553891.5
ENST00000556143.6
zinc finger FYVE-type containing 1
chr12_+_104064520 0.24 ENST00000229330.9
host cell factor C2
chr14_-_75981986 0.24 ENST00000238682.8
transforming growth factor beta 3
chrX_-_150898592 0.24 ENST00000355149.8
ENST00000466436.5
ENST00000370377.8
CD99 molecule like 2
chr16_-_21278282 0.23 ENST00000572914.2
crystallin mu
chr11_+_33039561 0.23 ENST00000334274.9
t-complex 11 like 1
chr8_+_76681208 0.23 ENST00000651372.2
zinc finger homeobox 4
chr20_-_32536383 0.23 ENST00000375678.7
nucleolar protein 4 like
chr5_+_150190035 0.22 ENST00000230671.7
ENST00000524041.1
solute carrier family 6 member 7
chr8_-_70607654 0.22 ENST00000521425.5
translocation associated membrane protein 1
chr11_+_6390439 0.22 ENST00000530395.1
ENST00000342245.9
ENST00000527275.5
sphingomyelin phosphodiesterase 1
chr9_+_116153783 0.22 ENST00000328252.4
pappalysin 1
chr2_+_56183973 0.22 ENST00000407595.3
coiled-coil domain containing 85A
chr10_+_13100075 0.22 ENST00000378747.8
ENST00000378757.6
ENST00000378752.7
ENST00000378748.7
optineurin
chr13_+_75788838 0.22 ENST00000497947.6
LIM domain 7
chr19_+_35030626 0.22 ENST00000638536.1
sodium voltage-gated channel beta subunit 1
chr22_+_35299800 0.21 ENST00000456128.5
ENST00000411850.5
ENST00000425375.5
ENST00000449058.7
target of myb1 membrane trafficking protein
chr11_+_72227881 0.21 ENST00000538751.5
ENST00000541756.5
inositol polyphosphate phosphatase like 1
chr2_+_53971072 0.21 ENST00000422521.2
ENST00000607452.6
acylphosphatase 2
chr3_-_64225436 0.21 ENST00000638394.2
prickle planar cell polarity protein 2
chr20_+_44531758 0.21 ENST00000372891.7
ENST00000372892.7
ENST00000372894.7
cAMP-dependent protein kinase inhibitor gamma
chr10_+_94089067 0.20 ENST00000371375.1
ENST00000675218.1
phospholipase C epsilon 1
chr8_-_73878816 0.20 ENST00000602593.6
ENST00000651945.1
ENST00000419880.7
ENST00000517608.5
ENST00000650817.1
ubiquitin conjugating enzyme E2 W
chr17_-_21253398 0.20 ENST00000611551.1
N-acetyltransferase domain containing 1
chr17_+_41226648 0.20 ENST00000377721.3
keratin associated protein 9-2
chr4_+_113292838 0.20 ENST00000672411.1
ENST00000673231.1
ankyrin 2
chr1_-_150876571 0.20 ENST00000354396.6
ENST00000358595.10
ENST00000505755.5
aryl hydrocarbon receptor nuclear translocator
chr10_+_94089034 0.20 ENST00000676102.1
ENST00000371385.8
phospholipase C epsilon 1
chr8_-_92017637 0.20 ENST00000422361.6
RUNX1 partner transcriptional co-repressor 1
chr19_+_35031263 0.19 ENST00000640135.1
ENST00000596348.2
sodium voltage-gated channel beta subunit 1
chr8_-_134510182 0.19 ENST00000521673.5
zinc finger and AT-hook domain containing
chr4_+_113292925 0.19 ENST00000673353.1
ENST00000505342.6
ENST00000672915.1
ENST00000509550.5
ankyrin 2
chr10_-_90921079 0.19 ENST00000371697.4
ankyrin repeat domain 1
chr4_+_37891060 0.18 ENST00000261439.9
ENST00000508802.5
ENST00000402522.1
TBC1 domain family member 1
chr14_+_52553273 0.18 ENST00000542169.6
ENST00000555622.1
G protein-coupled receptor 137C
chr1_-_150876697 0.18 ENST00000515192.5
aryl hydrocarbon receptor nuclear translocator
chr6_-_110415539 0.18 ENST00000368923.8
ENST00000368924.9
D-aspartate oxidase
chr15_+_92904447 0.18 ENST00000626782.2
chromodomain helicase DNA binding protein 2
chr12_+_68808143 0.18 ENST00000258149.11
ENST00000428863.6
ENST00000393412.7
MDM2 proto-oncogene
chr12_-_49904217 0.18 ENST00000550635.6
Fas apoptotic inhibitory molecule 2
chr12_-_55728977 0.18 ENST00000552164.5
CD63 molecule
chr14_+_22598224 0.18 ENST00000428304.6
ENST00000542041.1
ENST00000216327.10
abhydrolase domain containing 4, N-acyl phospholipase B
chr12_+_12785652 0.18 ENST00000356591.5
apolipoprotein L domain containing 1
chr14_+_52552830 0.17 ENST00000321662.11
G protein-coupled receptor 137C
chr17_+_44170695 0.17 ENST00000293414.6
ankyrin repeat and SOCS box containing 16
chr9_+_121268060 0.17 ENST00000373808.8
ENST00000432226.7
ENST00000449733.7
gelsolin
chr1_-_150697128 0.17 ENST00000427665.1
ENST00000271732.8
golgi phosphoprotein 3 like
chr3_+_191329342 0.17 ENST00000392455.9
coiled-coil domain containing 50
chr19_-_45782479 0.17 ENST00000447742.6
ENST00000354227.9
ENST00000291270.9
ENST00000683086.1
ENST00000343373.10
DM1 protein kinase
chr17_+_47209035 0.17 ENST00000572316.5
ENST00000354968.5
ENST00000576874.5
ENST00000536623.6
myosin light chain 4
chr20_-_18497218 0.17 ENST00000337227.9
RB binding protein 9, serine hydrolase
chr6_+_69232406 0.17 ENST00000238918.12
adhesion G protein-coupled receptor B3
chrX_+_136197039 0.17 ENST00000370683.6
four and a half LIM domains 1
chr10_+_74824919 0.17 ENST00000648828.1
ENST00000648725.1
lysine acetyltransferase 6B
chr11_-_67353503 0.16 ENST00000539074.1
ENST00000530584.5
ENST00000531239.2
ENST00000312419.8
ENST00000529704.5
DNA polymerase delta 4, accessory subunit
chrX_+_136196750 0.16 ENST00000539015.5
four and a half LIM domains 1
chr10_+_1056776 0.16 ENST00000650072.1
WD repeat domain 37
chrX_+_136197020 0.16 ENST00000370676.7
four and a half LIM domains 1
chr4_+_61200318 0.16 ENST00000683033.1
adhesion G protein-coupled receptor L3
chr1_-_19312068 0.16 ENST00000330072.9
ENST00000235835.8
aldo-keto reductase family 7 member A2
chr12_-_76486061 0.16 ENST00000548341.5
oxysterol binding protein like 8
chr16_-_79600698 0.16 ENST00000393350.1
MAF bZIP transcription factor
chr2_+_85753984 0.16 ENST00000306279.4
atonal bHLH transcription factor 8
chr12_+_26121984 0.16 ENST00000538142.5
sarcospan
chr14_-_52552493 0.16 ENST00000281741.9
ENST00000557374.1
thioredoxin domain containing 16
chr9_+_2159850 0.16 ENST00000416751.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr7_-_29990113 0.16 ENST00000426154.5
ENST00000421434.5
ENST00000434476.6
secernin 1
chr10_+_22316445 0.16 ENST00000448361.5
COMM domain containing 3
chr12_-_55728994 0.16 ENST00000257857.9
CD63 molecule
chr19_+_18588789 0.16 ENST00000450195.6
ENST00000358607.11
required for excision 1-B domain containing
chr12_+_32502114 0.16 ENST00000682739.1
ENST00000427716.7
ENST00000583694.2
FYVE, RhoGEF and PH domain containing 4
chr17_-_44268119 0.16 ENST00000399246.3
ENST00000262418.12
solute carrier family 4 member 1 (Diego blood group)
chr9_+_89605004 0.16 ENST00000252506.11
ENST00000375769.1
growth arrest and DNA damage inducible gamma
chr17_+_6444441 0.16 ENST00000250056.12
ENST00000571373.5
ENST00000570337.6
ENST00000572595.6
ENST00000572447.6
ENST00000576056.5
PICALM interacting mitotic regulator
chr18_+_3448456 0.16 ENST00000549780.5
TGFB induced factor homeobox 1
chr16_+_30372291 0.15 ENST00000568749.5
myosin light chain, phosphorylatable, fast skeletal muscle
chr7_+_18496231 0.15 ENST00000401921.5
histone deacetylase 9
chr1_-_243163310 0.15 ENST00000492145.1
ENST00000490813.5
ENST00000464936.5
centrosomal protein 170
chr11_-_1486763 0.15 ENST00000329957.7
MOB kinase activator 2
chr3_-_100114488 0.15 ENST00000477258.2
ENST00000354552.7
ENST00000331335.9
ENST00000398326.2
filamin A interacting protein 1 like
chr2_+_61905646 0.15 ENST00000311832.5
copper metabolism domain containing 1
chr2_-_65366650 0.15 ENST00000443619.6
sprouty related EVH1 domain containing 2
chr9_-_101594918 0.15 ENST00000374806.2
protein phosphatase 3 regulatory subunit B, beta
chr15_+_75336018 0.15 ENST00000567195.5
COMM domain containing 4
chr14_+_102922639 0.15 ENST00000299155.10
amnion associated transmembrane protein
chr7_-_76626127 0.14 ENST00000454397.1
POM121 and ZP3 fusion
chr22_+_30694851 0.14 ENST00000332585.11
oxysterol binding protein 2
chr11_-_62556230 0.14 ENST00000530285.5
AHNAK nucleoprotein
chr17_-_81937221 0.14 ENST00000402252.6
ENST00000583564.5
ENST00000585244.1
ENST00000337943.9
ENST00000579698.5
pyrroline-5-carboxylate reductase 1
chr10_+_22316375 0.14 ENST00000376836.8
ENST00000456711.5
ENST00000444869.5
ENST00000475460.6
ENST00000602390.5
ENST00000489125.2
COMM domain containing 3
COMMD3-BMI1 readthrough
chr5_+_50666917 0.14 ENST00000514342.6
poly(ADP-ribose) polymerase family member 8
chr5_+_138084015 0.14 ENST00000504809.5
ENST00000506684.6
ENST00000398754.1
Wnt family member 8A
chr5_+_141969074 0.14 ENST00000506938.5
ENST00000394520.7
ENST00000394514.6
ENST00000512565.5
ring finger protein 14
chr3_+_54123452 0.14 ENST00000620722.4
ENST00000490478.5
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr2_-_27071628 0.14 ENST00000447619.5
ENST00000429985.1
ENST00000456793.2
oligosaccharyltransferase complex subunit 4, non-catalytic
chr4_-_52038260 0.14 ENST00000381431.10
sarcoglycan beta
chr6_+_52423680 0.14 ENST00000538167.2
EF-hand domain containing 1
chr7_-_29989774 0.14 ENST00000242059.10
secernin 1
chr15_-_31870651 0.14 ENST00000307050.6
ENST00000560598.2
OTU deubiquitinase 7A
chr7_-_30550761 0.14 ENST00000598361.4
ENST00000440438.6
novel protein
GARS1 divergent transcript
chr5_-_88785493 0.14 ENST00000503554.4
myocyte enhancer factor 2C
chr15_+_75336078 0.14 ENST00000567377.5
ENST00000562789.5
ENST00000568301.1
COMM domain containing 4
chr9_+_2159672 0.14 ENST00000634343.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr6_+_46793379 0.14 ENST00000230588.9
ENST00000611727.2
meprin A subunit alpha
chr1_+_174875505 0.14 ENST00000486220.5
RAB GTPase activating protein 1 like
chr16_-_79600727 0.13 ENST00000326043.5
MAF bZIP transcription factor
chr17_-_81937320 0.13 ENST00000577624.5
ENST00000403172.8
ENST00000619204.4
ENST00000629768.2
pyrroline-5-carboxylate reductase 1
chrX_+_65588368 0.13 ENST00000609672.5
moesin
chr17_+_35243063 0.13 ENST00000542451.1
ENST00000299977.9
ENST00000592325.1
schlafen family member 5
chr19_-_33521749 0.13 ENST00000588328.6
ENST00000651901.1
ENST00000651646.1
ENST00000436370.7
ENST00000244137.12
ENST00000397032.8
peptidase D
chr4_-_139302516 0.13 ENST00000394228.5
ENST00000539387.5
NADH:ubiquinone oxidoreductase subunit C1
chr8_+_80486209 0.13 ENST00000426744.5
ENST00000455036.8
zinc finger and BTB domain containing 10
chr17_-_81937277 0.13 ENST00000405481.8
ENST00000329875.13
ENST00000585215.5
pyrroline-5-carboxylate reductase 1
chr15_+_75336053 0.13 ENST00000564815.5
ENST00000338995.10
ENST00000267935.13
COMM domain containing 4
chr9_-_90642855 0.13 ENST00000637905.1
DIRAS family GTPase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP4_MSC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1904761 negative regulation of myofibroblast differentiation(GO:1904761)
0.2 0.7 GO:0021593 rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658)
0.2 0.4 GO:0014806 smooth muscle hyperplasia(GO:0014806)
0.2 1.1 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 3.3 GO:0006527 arginine catabolic process(GO:0006527)
0.1 0.9 GO:0010966 regulation of phosphate transport(GO:0010966)
0.1 1.6 GO:0006824 cobalt ion transport(GO:0006824)
0.1 0.4 GO:0035638 patched ligand maturation(GO:0007225) signal maturation(GO:0035638)
0.1 0.6 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.1 1.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 1.7 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.1 1.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 0.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 0.2 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.1 0.2 GO:0003032 detection of oxygen(GO:0003032)
0.1 0.2 GO:0045062 extrathymic T cell selection(GO:0045062)
0.1 0.5 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.1 0.3 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.1 0.1 GO:0061317 canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317)
0.1 0.5 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.4 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 0.8 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 1.0 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.2 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 1.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.2 GO:0061743 motor learning(GO:0061743)
0.0 0.4 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.6 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.2 GO:0036369 transcription factor catabolic process(GO:0036369) cellular response to actinomycin D(GO:0072717)
0.0 0.4 GO:0001554 luteolysis(GO:0001554)
0.0 0.3 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.4 GO:0046886 positive regulation of hormone biosynthetic process(GO:0046886)
0.0 0.1 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.4 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 0.2 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.0 0.6 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.0 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.0 0.2 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.1 GO:1902966 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0 0.5 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.2 GO:0023021 termination of signal transduction(GO:0023021)
0.0 1.4 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.2 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.1 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.0 0.1 GO:0099403 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.0 0.1 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.0 0.2 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.0 0.4 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.4 GO:0045176 apical protein localization(GO:0045176)
0.0 0.4 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.1 GO:0018032 protein amidation(GO:0018032)
0.0 0.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.7 GO:2001046 positive regulation of integrin-mediated signaling pathway(GO:2001046)
0.0 0.1 GO:0035803 egg coat formation(GO:0035803)
0.0 0.1 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of B cell apoptotic process(GO:0002904) regulation of interleukin-18 production(GO:0032661)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.1 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.0 0.1 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.0 0.2 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.2 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0060913 visceral motor neuron differentiation(GO:0021524) cardiac cell fate determination(GO:0060913) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.0 0.2 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.1 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.0 0.2 GO:0030638 polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0 0.6 GO:0046596 regulation of viral entry into host cell(GO:0046596)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.0 0.3 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.1 GO:0060613 fat pad development(GO:0060613)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.0 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0 0.3 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.1 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0 0.1 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.0 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 0.1 GO:0071964 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.0 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.0 0.0 GO:0090274 regulation of somatostatin secretion(GO:0090273) positive regulation of somatostatin secretion(GO:0090274)
0.0 0.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.1 GO:0009838 abscission(GO:0009838)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.1 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.3 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.2 GO:0060712 spongiotrophoblast layer development(GO:0060712)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.1 1.0 GO:0005883 neurofilament(GO:0005883)
0.1 0.9 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.6 GO:0060171 stereocilium membrane(GO:0060171)
0.0 1.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.2 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.1 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.0 0.7 GO:0097431 pericentriolar material(GO:0000242) mitotic spindle pole(GO:0097431)
0.0 1.2 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 2.0 GO:0005776 autophagosome(GO:0005776)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.0 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.3 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0072357 glycogen granule(GO:0042587) PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.3 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.4 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 0.8 GO:0047057 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.1 1.1 GO:0043426 MRF binding(GO:0043426)
0.1 1.6 GO:0031419 cobalamin binding(GO:0031419)
0.1 1.0 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.5 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.1 0.3 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.4 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.3 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.0 0.2 GO:0032810 sterol response element binding(GO:0032810)
0.0 0.1 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.2 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0052815 medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816)
0.0 0.1 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.2 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.1 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.1 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.0 0.2 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.4 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.0 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.0 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.6 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.0 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.7 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins