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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for TP73

Z-value: 0.22

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Transcription factors associated with TP73

Gene Symbol Gene ID Gene Info
TP73
ENSG00000078900.15 tumor protein p73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP73hg38_v1_chr1_+_3698027_36980580.677.1e-02Click!

Activity profile of TP73 motif

Sorted Z-values of TP73 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_153615858 0.18 ENST00000476873.5
S100A14
S100 calcium binding protein A14
chr19_+_44777860 0.17 ENST00000341505.4
ENST00000647358.2
CBLC
Cbl proto-oncogene C
chr14_+_75279637 0.15 ENST00000555686.1
ENST00000555672.1
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
chr19_+_35106510 0.13 ENST00000648240.1
ENSG00000285526.1
novel protein
chr14_+_75278820 0.13 ENST00000554617.1
ENST00000554212.5
ENST00000535987.5
ENST00000303562.9
ENST00000555242.1
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
chr10_+_46375645 0.13 ENST00000622769.4
ANXA8L1
annexin A8 like 1
chr10_+_46375619 0.12 ENST00000584982.7
ENST00000613703.4
ANXA8L1
annexin A8 like 1
chr17_+_75754618 0.11 ENST00000584939.1
ITGB4
integrin subunit beta 4
chr15_+_40844018 0.11 ENST00000344051.8
ENST00000562057.6
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr3_+_136957948 0.10 ENST00000329582.9
IL20RB
interleukin 20 receptor subunit beta
chr11_+_60429595 0.10 ENST00000528905.1
ENST00000528093.1
MS4A5
membrane spanning 4-domains A5
chr1_-_204190324 0.09 ENST00000638118.1
REN
renin
chr3_-_69386079 0.09 ENST00000398540.8
FRMD4B
FERM domain containing 4B
chr12_-_56488153 0.08 ENST00000311966.9
GLS2
glutaminase 2
chr19_-_291132 0.08 ENST00000327790.7
PLPP2
phospholipid phosphatase 2
chr6_+_36676455 0.07 ENST00000615513.4
CDKN1A
cyclin dependent kinase inhibitor 1A
chr6_+_36676489 0.07 ENST00000448526.6
CDKN1A
cyclin dependent kinase inhibitor 1A
chr11_+_60429567 0.07 ENST00000300190.7
MS4A5
membrane spanning 4-domains A5
chr12_-_6635938 0.07 ENST00000329858.9
LPAR5
lysophosphatidic acid receptor 5
chr3_+_50205254 0.07 ENST00000614032.5
ENST00000445096.5
SLC38A3
solute carrier family 38 member 3
chr2_+_95274439 0.07 ENST00000317620.14
ENST00000403131.6
ENST00000317668.8
PROM2
prominin 2
chr10_-_103452356 0.06 ENST00000260743.10
CALHM2
calcium homeostasis modulator family member 2
chr10_+_46375721 0.06 ENST00000616785.1
ENST00000611655.1
ENST00000619162.5
ENSG00000285402.1
ANXA8L1
novel transcript
annexin A8 like 1
chr10_-_103452384 0.06 ENST00000369788.7
CALHM2
calcium homeostasis modulator family member 2
chr9_+_35673917 0.06 ENST00000617161.1
ENST00000378357.9
CA9
carbonic anhydrase 9
chr3_-_185821092 0.05 ENST00000421047.3
IGF2BP2
insulin like growth factor 2 mRNA binding protein 2
chr18_-_55586092 0.05 ENST00000563888.6
ENST00000540999.5
ENST00000627685.2
TCF4
transcription factor 4
chr18_-_55585773 0.05 ENST00000563824.5
ENST00000626425.2
ENST00000566514.5
ENST00000568673.5
ENST00000562847.5
ENST00000568147.5
TCF4
transcription factor 4
chr17_-_44123628 0.05 ENST00000587135.1
ENST00000225983.10
ENST00000682912.1
ENST00000588703.5
HDAC5
histone deacetylase 5
chr6_-_46735351 0.04 ENST00000274793.12
PLA2G7
phospholipase A2 group VII
chr1_+_64745089 0.04 ENST00000294428.7
ENST00000371072.8
RAVER2
ribonucleoprotein, PTB binding 2
chr3_+_44976236 0.04 ENST00000265564.8
EXOSC7
exosome component 7
chr2_+_74002685 0.04 ENST00000305799.8
TET3
tet methylcytosine dioxygenase 3
chr12_+_49295138 0.04 ENST00000257860.9
PRPH
peripherin
chr20_-_54173516 0.03 ENST00000395955.7
CYP24A1
cytochrome P450 family 24 subfamily A member 1
chr12_-_31729010 0.03 ENST00000537562.5
ENST00000537960.5
ENST00000281471.11
ENST00000536761.5
ENST00000542781.5
ENST00000457428.6
AMN1
antagonist of mitotic exit network 1 homolog
chr4_+_38664189 0.03 ENST00000514033.1
ENST00000261438.10
KLF3
Kruppel like factor 3
chr2_+_176116768 0.03 ENST00000249501.5
HOXD10
homeobox D10
chr19_+_43533384 0.03 ENST00000601282.1
ZNF575
zinc finger protein 575
chr17_+_39200507 0.03 ENST00000678573.1
RPL19
ribosomal protein L19
chr6_-_46735693 0.03 ENST00000537365.1
PLA2G7
phospholipase A2 group VII
chr19_-_35490456 0.03 ENST00000338897.4
ENST00000484218.6
KRTDAP
keratinocyte differentiation associated protein
chr16_+_30923565 0.03 ENST00000338343.10
FBXL19
F-box and leucine rich repeat protein 19
chr16_+_2019777 0.03 ENST00000566435.4
NPW
neuropeptide W
chrX_+_153642473 0.03 ENST00000370167.8
DUSP9
dual specificity phosphatase 9
chr17_+_39200334 0.03 ENST00000579260.5
ENST00000582193.5
RPL19
ribosomal protein L19
chr14_-_100569780 0.03 ENST00000355173.7
BEGAIN
brain enriched guanylate kinase associated
chr18_+_13277351 0.03 ENST00000679091.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr17_+_39200275 0.03 ENST00000225430.9
RPL19
ribosomal protein L19
chr11_-_236821 0.03 ENST00000529382.5
ENST00000528469.1
SIRT3
sirtuin 3
chr14_+_22086401 0.03 ENST00000390451.2
TRAV23DV6
T cell receptor alpha variable 23/delta variable 6
chr16_+_56191476 0.03 ENST00000262493.12
GNAO1
G protein subunit alpha o1
chr19_+_19516216 0.03 ENST00000507754.9
ENST00000503283.5
ENST00000428459.6
ENST00000555938.1
NDUFA13
ENSG00000258674.5
NADH:ubiquinone oxidoreductase subunit A13
novel protein
chr2_+_219572304 0.03 ENST00000243786.3
INHA
inhibin subunit alpha
chr17_+_39200302 0.02 ENST00000579374.5
RPL19
ribosomal protein L19
chr17_-_40867200 0.02 ENST00000647902.1
ENST00000251643.5
KRT12
keratin 12
chr16_+_74999003 0.02 ENST00000335325.9
ENST00000320619.10
ZNRF1
zinc and ring finger 1
chr17_+_21288029 0.02 ENST00000526076.6
ENST00000361818.9
ENST00000316920.10
MAP2K3
mitogen-activated protein kinase kinase 3
chr17_+_7888783 0.02 ENST00000330494.12
ENST00000358181.8
CHD3
chromodomain helicase DNA binding protein 3
chr19_+_41860236 0.02 ENST00000601492.5
ENST00000600467.6
ENST00000598742.6
ENST00000221975.6
ENST00000598261.2
RPS19
ribosomal protein S19
chr2_-_26641363 0.02 ENST00000288861.5
CIB4
calcium and integrin binding family member 4
chr16_-_8797624 0.02 ENST00000333050.7
TMEM186
transmembrane protein 186
chr9_+_36169382 0.02 ENST00000335119.4
CCIN
calicin
chr19_-_38735405 0.02 ENST00000597987.5
ENST00000595177.1
CAPN12
calpain 12
chr17_-_76027296 0.02 ENST00000301607.8
EVPL
envoplakin
chr11_+_66466745 0.02 ENST00000349459.10
ENST00000320740.12
ENST00000524466.5
ENST00000526296.5
PELI3
pellino E3 ubiquitin protein ligase family member 3
chr4_+_6716131 0.02 ENST00000320776.5
BLOC1S4
biogenesis of lysosomal organelles complex 1 subunit 4
chr14_+_103385450 0.02 ENST00000416682.6
MARK3
microtubule affinity regulating kinase 3
chr22_-_37580075 0.02 ENST00000215886.6
LGALS2
galectin 2
chr8_+_119873710 0.02 ENST00000523492.5
ENST00000286234.6
DEPTOR
DEP domain containing MTOR interacting protein
chr12_+_82358496 0.02 ENST00000248306.8
ENST00000548200.5
METTL25
methyltransferase like 25
chr2_+_158968608 0.02 ENST00000263635.8
TANC1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr16_-_636270 0.01 ENST00000397665.6
ENST00000397666.6
ENST00000301686.13
ENST00000338401.8
ENST00000397664.8
ENST00000568830.1
ENST00000614890.4
METTL26
methyltransferase like 26
chr4_-_20984011 0.01 ENST00000382149.9
KCNIP4
potassium voltage-gated channel interacting protein 4
chr19_+_41350911 0.01 ENST00000539627.5
TMEM91
transmembrane protein 91
chr2_+_89884740 0.01 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr10_-_103479240 0.01 ENST00000369783.4
CALHM3
calcium homeostasis modulator 3
chr14_+_103385506 0.01 ENST00000303622.13
MARK3
microtubule affinity regulating kinase 3
chr10_+_68901258 0.01 ENST00000373585.8
DDX50
DExD-box helicase 50
chr20_-_63572455 0.01 ENST00000467148.1
HELZ2
helicase with zinc finger 2
chr20_-_59940289 0.01 ENST00000370996.5
PPP1R3D
protein phosphatase 1 regulatory subunit 3D
chr19_+_43716095 0.01 ENST00000596627.1
IRGC
immunity related GTPase cinema
chr1_+_26159071 0.01 ENST00000374268.5
FAM110D
family with sequence similarity 110 member D
chr14_+_103385374 0.01 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
MARK3
microtubule affinity regulating kinase 3
chr7_-_128405930 0.01 ENST00000470772.5
ENST00000480861.5
ENST00000496200.5
IMPDH1
inosine monophosphate dehydrogenase 1
chr20_-_54173976 0.01 ENST00000216862.8
CYP24A1
cytochrome P450 family 24 subfamily A member 1
chr10_-_77926724 0.01 ENST00000372391.7
DLG5
discs large MAGUK scaffold protein 5
chr1_+_156815633 0.01 ENST00000392302.7
ENST00000674537.1
NTRK1
neurotrophic receptor tyrosine kinase 1
chr9_-_135499846 0.01 ENST00000429260.7
C9orf116
chromosome 9 open reading frame 116
chr11_+_237016 0.01 ENST00000352303.9
PSMD13
proteasome 26S subunit, non-ATPase 13
chr17_-_82101850 0.01 ENST00000583053.1
CCDC57
coiled-coil domain containing 57
chr17_-_5123102 0.01 ENST00000250076.7
ZNF232
zinc finger protein 232
chr2_+_69741974 0.01 ENST00000409920.5
ANXA4
annexin A4
chr11_+_236957 0.01 ENST00000532097.6
ENST00000431206.6
ENST00000528906.5
ENST00000621534.4
PSMD13
proteasome 26S subunit, non-ATPase 13
chrX_-_132094263 0.01 ENST00000370879.5
FRMD7
FERM domain containing 7
chr10_+_62804710 0.01 ENST00000373783.3
ADO
2-aminoethanethiol dioxygenase
chr5_+_126423122 0.01 ENST00000515200.5
GRAMD2B
GRAM domain containing 2B
chr9_+_84669760 0.01 ENST00000304053.10
NTRK2
neurotrophic receptor tyrosine kinase 2
chr5_+_126423176 0.01 ENST00000542322.5
ENST00000544396.5
GRAMD2B
GRAM domain containing 2B
chr16_+_56191728 0.01 ENST00000638705.1
ENST00000262494.12
GNAO1
G protein subunit alpha o1
chr16_+_8797813 0.01 ENST00000268261.9
ENST00000569958.5
PMM2
phosphomannomutase 2
chr5_+_126423363 0.01 ENST00000285689.8
GRAMD2B
GRAM domain containing 2B
chrX_+_131058340 0.01 ENST00000276211.10
ENST00000370922.5
ARHGAP36
Rho GTPase activating protein 36
chr1_+_109539865 0.01 ENST00000618721.4
ENST00000527748.5
ENST00000616874.1
GPR61
G protein-coupled receptor 61
chr3_+_48440246 0.01 ENST00000438607.2
TMA7
translation machinery associated 7 homolog
chr3_-_48898813 0.01 ENST00000319017.5
ENST00000430379.5
SLC25A20
solute carrier family 25 member 20
chr17_-_76027212 0.01 ENST00000586740.1
EVPL
envoplakin
chr2_-_27134611 0.01 ENST00000406567.7
ENST00000260643.7
PREB
prolactin regulatory element binding
chr19_+_12995554 0.01 ENST00000397661.6
NFIX
nuclear factor I X
chr18_-_4455257 0.01 ENST00000581527.5
DLGAP1
DLG associated protein 1
chr3_+_42160160 0.01 ENST00000341421.7
ENST00000396175.5
TRAK1
trafficking kinesin protein 1
chr4_+_105710809 0.01 ENST00000360505.9
ENST00000510865.5
ENST00000509336.5
GSTCD
glutathione S-transferase C-terminal domain containing
chr20_+_59940362 0.01 ENST00000360816.8
FAM217B
family with sequence similarity 217 member B
chrX_-_139642518 0.01 ENST00000370573.8
ENST00000338585.6
MCF2
MCF.2 cell line derived transforming sequence
chr16_+_89918855 0.01 ENST00000555147.2
MC1R
melanocortin 1 receptor
chr1_-_203086001 0.01 ENST00000241651.5
MYOG
myogenin
chr19_+_44751251 0.00 ENST00000444487.1
BCL3
BCL3 transcription coactivator
chr19_+_17215716 0.00 ENST00000593597.1
USE1
unconventional SNARE in the ER 1
chr12_-_82358380 0.00 ENST00000256151.8
ENST00000552377.5
CCDC59
coiled-coil domain containing 59
chr1_+_16043776 0.00 ENST00000375679.9
CLCNKB
chloride voltage-gated channel Kb
chr6_+_31547560 0.00 ENST00000376148.9
ENST00000376145.8
NFKBIL1
NFKB inhibitor like 1
chr12_-_116881431 0.00 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein
chr14_-_25050111 0.00 ENST00000323944.9
STXBP6
syntaxin binding protein 6
chr1_+_16043736 0.00 ENST00000619181.4
CLCNKB
chloride voltage-gated channel Kb
chr14_-_25049889 0.00 ENST00000419632.6
ENST00000396700.5
STXBP6
syntaxin binding protein 6
chr8_+_144504131 0.00 ENST00000394955.3
GPT
glutamic--pyruvic transaminase
chr19_+_43716070 0.00 ENST00000244314.6
IRGC
immunity related GTPase cinema
chr2_-_38602626 0.00 ENST00000378915.7
HNRNPLL
heterogeneous nuclear ribonucleoprotein L like
chr14_-_24576240 0.00 ENST00000216336.3
CTSG
cathepsin G
chr19_+_41114430 0.00 ENST00000331105.7
CYP2F1
cytochrome P450 family 2 subfamily F member 1
chr2_+_127535746 0.00 ENST00000428314.5
ENST00000409816.7
MYO7B
myosin VIIB

Network of associatons between targets according to the STRING database.

First level regulatory network of TP73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.3 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0015817 histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.1 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.1 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.0 0.0 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.0 GO:0044725 chromatin reprogramming in the zygote(GO:0044725)
0.0 0.1 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 0.1 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0 0.0 GO:0042369 vitamin D catabolic process(GO:0042369)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.1 GO:0044393 microspike(GO:0044393)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors