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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for VAX2_RHOXF2

Z-value: 0.50

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Transcription factors associated with VAX2_RHOXF2

Gene Symbol Gene ID Gene Info
VAX2
ENSG00000116035.4 ventral anterior homeobox 2
RHOXF2
ENSG00000131721.6 Rhox homeobox family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
VAX2hg38_v1_chr2_+_70900546_70900617-0.521.8e-01Click!
RHOXF2hg38_v1_chrX_+_120158600_1201586240.353.9e-01Click!

Activity profile of VAX2_RHOXF2 motif

Sorted Z-values of VAX2_RHOXF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_56579555 0.93 ENST00000371250.4
PLPP3
phospholipid phosphatase 3
chr5_-_20575850 0.78 ENST00000507958.5
CDH18
cadherin 18
chr3_+_157436842 0.67 ENST00000295927.4
PTX3
pentraxin 3
chr19_+_49513353 0.49 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr4_-_185775271 0.49 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
SORBS2
sorbin and SH3 domain containing 2
chr16_+_53099100 0.46 ENST00000565832.5
CHD9
chromodomain helicase DNA binding protein 9
chr1_+_159204860 0.46 ENST00000368122.4
ENST00000368121.6
ACKR1
atypical chemokine receptor 1 (Duffy blood group)
chr4_-_137532452 0.39 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
PCDH18
protocadherin 18
chr9_-_92404559 0.31 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr5_+_172641241 0.26 ENST00000369800.6
ENST00000520919.5
ENST00000522853.5
NEURL1B
neuralized E3 ubiquitin protein ligase 1B
chr2_-_189179754 0.24 ENST00000374866.9
ENST00000618828.1
COL5A2
collagen type V alpha 2 chain
chr11_-_111923722 0.18 ENST00000527950.5
CRYAB
crystallin alpha B
chr3_-_191282383 0.18 ENST00000427544.6
UTS2B
urotensin 2B
chr6_+_26440472 0.17 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
BTN3A3
butyrophilin subfamily 3 member A3
chr12_+_26195543 0.16 ENST00000242729.7
SSPN
sarcospan
chr20_+_45416551 0.15 ENST00000639292.1
PIGT
phosphatidylinositol glycan anchor biosynthesis class T
chr12_+_26195313 0.15 ENST00000422622.3
SSPN
sarcospan
chr7_+_100119607 0.15 ENST00000262932.5
CNPY4
canopy FGF signaling regulator 4
chr12_+_26195647 0.14 ENST00000535504.1
SSPN
sarcospan
chr2_-_213151590 0.14 ENST00000374319.8
ENST00000457361.5
ENST00000451136.6
ENST00000434687.6
IKZF2
IKAROS family zinc finger 2
chr6_+_29550407 0.14 ENST00000641137.1
OR2I1P
olfactory receptor family 2 subfamily I member 1 pseudogene
chr11_+_92969651 0.14 ENST00000257068.3
ENST00000528076.1
MTNR1B
melatonin receptor 1B
chr8_-_42768602 0.13 ENST00000534622.5
CHRNA6
cholinergic receptor nicotinic alpha 6 subunit
chr6_+_26402289 0.13 ENST00000414912.2
BTN3A1
butyrophilin subfamily 3 member A1
chr7_+_138460238 0.13 ENST00000343526.9
TRIM24
tripartite motif containing 24
chr2_+_169069537 0.11 ENST00000428522.5
ENST00000450153.1
ENST00000674881.1
ENST00000421653.5
DHRS9
dehydrogenase/reductase 9
chrX_+_7219431 0.10 ENST00000674499.1
ENST00000217961.5
STS
steroid sulfatase
chr20_-_35147285 0.10 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr4_-_65670339 0.10 ENST00000273854.7
EPHA5
EPH receptor A5
chr9_+_122371014 0.10 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr15_+_73926443 0.10 ENST00000261921.8
LOXL1
lysyl oxidase like 1
chr4_-_65670478 0.09 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPHA5
EPH receptor A5
chr12_+_119668109 0.09 ENST00000229328.10
ENST00000630317.1
PRKAB1
protein kinase AMP-activated non-catalytic subunit beta 1
chrX_+_43656289 0.09 ENST00000338702.4
MAOA
monoamine oxidase A
chr5_+_174724549 0.09 ENST00000239243.7
ENST00000507785.2
MSX2
msh homeobox 2
chr20_+_15196834 0.09 ENST00000402914.5
MACROD2
mono-ADP ribosylhydrolase 2
chr7_+_12687625 0.09 ENST00000651779.1
ENST00000404894.1
ARL4A
ADP ribosylation factor like GTPase 4A
chr11_+_33039996 0.09 ENST00000432887.5
ENST00000528898.1
ENST00000531632.6
TCP11L1
t-complex 11 like 1
chr12_+_130953898 0.08 ENST00000261654.10
ADGRD1
adhesion G protein-coupled receptor D1
chr10_-_27240505 0.08 ENST00000375888.5
ENST00000676732.1
ACBD5
acyl-CoA binding domain containing 5
chr17_-_42185452 0.08 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr5_-_126595237 0.07 ENST00000637206.1
ENST00000553117.5
ALDH7A1
aldehyde dehydrogenase 7 family member A1
chr15_-_37101205 0.07 ENST00000338564.9
ENST00000558313.5
ENST00000340545.9
MEIS2
Meis homeobox 2
chr7_+_71132123 0.07 ENST00000333538.10
GALNT17
polypeptide N-acetylgalactosaminyltransferase 17
chr3_+_158801926 0.07 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
MFSD1
major facilitator superfamily domain containing 1
chr11_-_62754141 0.07 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
ZBTB3
zinc finger and BTB domain containing 3
chr3_-_142029108 0.07 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr6_+_26402237 0.07 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
BTN3A1
butyrophilin subfamily 3 member A1
chr11_-_7941708 0.06 ENST00000642047.1
OR10A3
olfactory receptor family 10 subfamily A member 3
chr17_+_68515399 0.06 ENST00000588188.6
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
chr9_+_72577788 0.06 ENST00000645208.2
TMC1
transmembrane channel like 1
chr3_-_165078480 0.06 ENST00000264382.8
SI
sucrase-isomaltase
chr9_+_72577369 0.06 ENST00000651183.1
TMC1
transmembrane channel like 1
chr2_-_74391837 0.06 ENST00000417090.1
ENST00000409868.5
ENST00000680606.1
DCTN1
dynactin subunit 1
chr17_+_7407838 0.05 ENST00000302926.7
NLGN2
neuroligin 2
chr20_+_58907981 0.05 ENST00000656419.1
GNAS
GNAS complex locus
chrX_+_10158448 0.05 ENST00000380829.5
ENST00000421085.7
ENST00000674669.1
ENST00000454850.1
CLCN4
chloride voltage-gated channel 4
chr2_+_186694007 0.05 ENST00000304698.10
FAM171B
family with sequence similarity 171 member B
chr2_-_40453438 0.05 ENST00000455476.5
SLC8A1
solute carrier family 8 member A1
chr14_-_52791597 0.05 ENST00000216410.8
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr7_+_6615576 0.05 ENST00000457543.4
ZNF853
zinc finger protein 853
chr1_+_34792990 0.05 ENST00000450137.1
ENST00000342280.5
GJA4
gap junction protein alpha 4
chrX_-_77634229 0.05 ENST00000675732.1
ATRX
ATRX chromatin remodeler
chr14_+_64549950 0.05 ENST00000298705.6
PPP1R36
protein phosphatase 1 regulatory subunit 36
chr17_+_45161070 0.05 ENST00000593138.6
ENST00000586681.6
HEXIM2
HEXIM P-TEFb complex subunit 2
chr4_+_168497066 0.04 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr7_-_100119840 0.04 ENST00000437822.6
TAF6
TATA-box binding protein associated factor 6
chrX_-_155071064 0.04 ENST00000369484.8
ENST00000369476.8
CMC4
MTCP1
C-X9-C motif containing 4
mature T cell proliferation 1
chr7_-_100119323 0.04 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TAF6
TATA-box binding protein associated factor 6
chr11_-_31509569 0.04 ENST00000526776.5
IMMP1L
inner mitochondrial membrane peptidase subunit 1
chr19_-_45584769 0.03 ENST00000263275.5
OPA3
outer mitochondrial membrane lipid metabolism regulator OPA3
chr4_+_168497044 0.03 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr1_+_212791828 0.03 ENST00000532324.5
ENST00000530441.5
ENST00000526641.5
ENST00000531963.5
ENST00000366973.8
ENST00000366974.9
ENST00000526997.5
ENST00000488246.6
TATDN3
TatD DNase domain containing 3
chrX_+_73563190 0.03 ENST00000373504.10
ENST00000373502.9
CHIC1
cysteine rich hydrophobic domain 1
chr1_-_211134135 0.03 ENST00000638983.1
ENST00000271751.10
ENST00000639952.1
ENSG00000284299.1
KCNH1
novel protein
potassium voltage-gated channel subfamily H member 1
chr14_+_20455210 0.03 ENST00000557344.5
ENST00000216714.8
ENST00000398030.8
ENST00000557181.5
ENST00000555839.5
ENST00000553368.1
ENST00000556054.5
ENST00000557054.1
ENST00000557592.5
ENST00000557150.5
APEX1
apurinic/apyrimidinic endodeoxyribonuclease 1
chr14_+_20455185 0.03 ENST00000555414.5
ENST00000553681.5
APEX1
apurinic/apyrimidinic endodeoxyribonuclease 1
chr5_-_150449676 0.03 ENST00000312037.6
RPS14
ribosomal protein S14
chr10_+_70052582 0.03 ENST00000676699.1
MACROH2A2
macroH2A.2 histone
chr2_-_74392025 0.03 ENST00000440727.1
ENST00000409240.5
DCTN1
dynactin subunit 1
chr1_+_174700413 0.03 ENST00000529145.6
ENST00000325589.9
RABGAP1L
RAB GTPase activating protein 1 like
chr11_+_72189528 0.03 ENST00000312293.9
FOLR1
folate receptor alpha
chr18_+_34976928 0.03 ENST00000591734.5
ENST00000413393.5
ENST00000589180.5
ENST00000587359.5
MAPRE2
microtubule associated protein RP/EB family member 2
chr5_-_150449696 0.03 ENST00000401695.8
RPS14
ribosomal protein S14
chr7_+_55365317 0.03 ENST00000254770.3
LANCL2
LanC like 2
chr12_-_50249883 0.03 ENST00000550592.1
LIMA1
LIM domain and actin binding 1
chrX_+_136648138 0.03 ENST00000370629.7
CD40LG
CD40 ligand
chr2_+_90220727 0.02 ENST00000471857.2
IGKV1D-8
immunoglobulin kappa variable 1D-8
chr5_-_150449731 0.02 ENST00000407193.7
RPS14
ribosomal protein S14
chr9_-_21228222 0.02 ENST00000413767.2
IFNA17
interferon alpha 17
chr9_-_134068012 0.02 ENST00000303407.12
BRD3
bromodomain containing 3
chr8_-_100649660 0.02 ENST00000311812.7
SNX31
sorting nexin 31
chr12_-_118359105 0.02 ENST00000541186.5
ENST00000539872.5
TAOK3
TAO kinase 3
chr19_+_15728024 0.02 ENST00000305899.5
OR10H2
olfactory receptor family 10 subfamily H member 2
chrX_+_136648214 0.02 ENST00000370628.2
CD40LG
CD40 ligand
chr10_-_17129786 0.02 ENST00000377833.10
CUBN
cubilin
chr16_+_72054477 0.02 ENST00000355906.10
ENST00000570083.5
ENST00000228226.12
ENST00000398131.6
ENST00000569639.5
ENST00000564499.5
ENST00000357763.8
ENST00000613898.1
ENST00000562526.5
ENST00000565574.5
ENST00000568417.6
HP
haptoglobin
chr8_+_7926337 0.02 ENST00000400120.3
ZNF705B
zinc finger protein 705B
chr11_-_122116215 0.02 ENST00000560104.2
BLID
BH3-like motif containing, cell death inducer
chr14_+_21997531 0.02 ENST00000390445.2
TRAV17
T cell receptor alpha variable 17
chr10_-_97445850 0.02 ENST00000477692.6
ENST00000485122.6
ENST00000370886.9
ENST00000370885.8
ENST00000370902.8
ENST00000370884.5
EXOSC1
exosome component 1
chr11_+_72189659 0.01 ENST00000393681.6
FOLR1
folate receptor alpha
chr17_-_10469558 0.01 ENST00000255381.2
MYH4
myosin heavy chain 4
chr9_-_21187671 0.01 ENST00000421715.2
IFNA4
interferon alpha 4
chr17_-_41047267 0.01 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr5_+_141177790 0.01 ENST00000239444.4
ENST00000623995.1
PCDHB8
ENSG00000279472.1
protocadherin beta 8
novel transcript
chr10_+_18260715 0.01 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr16_+_72063226 0.01 ENST00000540303.7
ENST00000356967.6
ENST00000561690.1
HPR
haptoglobin-related protein
chr19_-_45584810 0.01 ENST00000323060.3
OPA3
outer mitochondrial membrane lipid metabolism regulator OPA3
chr11_+_24496988 0.01 ENST00000336930.11
LUZP2
leucine zipper protein 2
chr18_-_69956924 0.01 ENST00000581982.5
ENST00000280200.8
CD226
CD226 molecule
chr21_-_36542600 0.01 ENST00000399136.5
CLDN14
claudin 14
chr14_+_71933116 0.01 ENST00000553530.5
ENST00000556437.5
RGS6
regulator of G protein signaling 6
chr1_-_212791762 0.01 ENST00000626725.1
ENST00000366977.8
ENST00000366976.3
NSL1
NSL1 component of MIS12 kinetochore complex
chr19_+_24033399 0.01 ENST00000664647.1
ENST00000656993.1
ENST00000666101.1
ENST00000613065.4
ENSG00000268362.6
ZNF254
novel transcript
zinc finger protein 254
chr11_+_124183219 0.01 ENST00000641351.2
OR10D3
olfactory receptor family 10 subfamily D member 3
chr16_+_69311339 0.01 ENST00000254950.13
VPS4A
vacuolar protein sorting 4 homolog A
chr6_-_137173644 0.01 ENST00000296980.7
ENST00000349184.8
ENST00000339602.3
IL22RA2
interleukin 22 receptor subunit alpha 2
chr6_-_82247697 0.01 ENST00000306270.12
ENST00000610980.4
IBTK
inhibitor of Bruton tyrosine kinase
chr19_+_41262480 0.00 ENST00000352456.7
ENST00000595018.5
ENST00000597725.5
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U like 1
chr13_+_35476740 0.00 ENST00000537702.5
NBEA
neurobeachin
chr5_+_129748091 0.00 ENST00000564719.2
MINAR2
membrane integral NOTCH2 associated receptor 2
chr17_+_50746614 0.00 ENST00000513969.5
ENST00000503728.1
LUC7L3
LUC7 like 3 pre-mRNA splicing factor
chr20_-_31390483 0.00 ENST00000376315.2
DEFB119
defensin beta 119
chr5_+_177384430 0.00 ENST00000512593.5
ENST00000324417.6
SLC34A1
solute carrier family 34 member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX2_RHOXF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.2 0.5 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.9 GO:0008354 germ cell migration(GO:0008354)
0.0 0.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.0 0.0 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.1 GO:0090427 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.0 0.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.1 GO:0097698 telomere maintenance via base-excision repair(GO:0097698)
0.0 0.1 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.0 GO:0099404 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.0 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713)
0.0 0.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.1 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.4 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.0 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.5 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 0.5 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.7 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.5 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.0 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.0 GO:0061714 folic acid receptor activity(GO:0061714)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions