Motif ID: AAGGCAC

Z-value: 1.242


Mature miRNA associated with seed AAGGCAC:

NamemiRBase Accession
hsa-miR-124-3p.1 MIMAT0000422



Activity profile for motif AAGGCAC.

activity profile for motif AAGGCAC


Sorted Z-values histogram for motif AAGGCAC

Sorted Z-values for motif AAGGCAC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAGGCAC

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_149365827 5.419 ENST00000344721.4
 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr21_+_36041688 3.644 ENST00000360731.3
ENST00000349499.2
 CLIC6

chloride intracellular channel 6

chr1_+_228870824 3.451 ENST00000366691.3
 RHOU
ras homolog family member U
chr18_-_45663666 3.267 ENST00000535628.2
 ZBTB7C
zinc finger and BTB domain containing 7C
chr6_-_90121938 3.021 ENST00000369415.4
 RRAGD
Ras-related GTP binding D
chr4_+_25657444 2.976 ENST00000504570.1
ENST00000382051.3
 SLC34A2

solute carrier family 34 (type II sodium/phosphate contransporter), member 2

chr19_+_709101 2.896 ENST00000338448.5
 PALM
paralemmin
chr14_+_67999999 2.826 ENST00000329153.5
 PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr19_-_7990991 2.704 ENST00000318978.4
 CTXN1
cortexin 1
chr5_-_101632153 2.548 ENST00000310954.6
 SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr17_+_68165657 2.528 ENST00000243457.3
 KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr14_+_77648167 2.430 ENST00000554346.1
ENST00000298351.4
 TMEM63C

transmembrane protein 63C

chr15_+_45315302 2.334 ENST00000267814.9
 SORD
sorbitol dehydrogenase
chr5_-_100238956 2.326 ENST00000231461.5
 ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr15_-_49255632 2.320 ENST00000332408.4
 SHC4
SHC (Src homology 2 domain containing) family, member 4
chr3_+_160473996 2.277 ENST00000498165.1
 PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr19_+_32896697 2.224 ENST00000586987.1
 DPY19L3
dpy-19-like 3 (C. elegans)
chr6_+_17281573 2.206 ENST00000379052.5
 RBM24
RNA binding motif protein 24
chr9_-_89562104 2.167 ENST00000298743.7
 GAS1
growth arrest-specific 1
chr7_+_121513143 2.121 ENST00000393386.2
 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 312 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 4.7 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 3.3 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.4 3.0 GO:0071233 cellular response to leucine(GO:0071233)
0.3 3.0 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.4 2.9 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.4 2.9 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.2 2.6 GO:0055089 fatty acid homeostasis(GO:0055089)
0.8 2.5 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.2 2.5 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.2 2.4 GO:0042659 regulation of cell fate specification(GO:0042659)
0.0 2.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.8 2.3 GO:0006059 hexitol metabolic process(GO:0006059)
0.2 2.3 GO:0015677 copper ion import(GO:0015677)
0.3 2.2 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 2.2 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307)
0.0 2.2 GO:0016266 O-glycan processing(GO:0016266)
0.4 2.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.3 2.0 GO:0060005 vestibular reflex(GO:0060005)
0.1 2.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0034707 chloride channel complex(GO:0034707)
0.1 3.8 GO:0031526 brush border membrane(GO:0031526)
0.0 3.8 GO:0016605 PML body(GO:0016605)
0.5 3.0 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 2.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 2.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 2.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 2.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.7 2.1 GO:0072534 perineuronal net(GO:0072534)
0.7 2.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.8 GO:0002102 podosome(GO:0002102)
0.0 1.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.7 GO:0005884 actin filament(GO:0005884)
0.1 1.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.3 GO:0043235 receptor complex(GO:0043235)
0.3 1.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 216 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 3.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 3.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.3 3.0 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 3.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6 2.9 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.0 2.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 2.5 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 2.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 2.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.3 2.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 2.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 2.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 2.0 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 2.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.2 1.9 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.0 1.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.6 1.8 GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405)
0.2 1.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 4.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 2.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.8 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 1.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 1.1 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 1.1 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.0 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 3.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.5 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 2.1 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 1.8 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 1.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.7 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.5 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.5 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.5 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.1 1.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.2 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels