Motif ID: AAUACUG

Z-value: 1.324


Mature miRNA associated with seed AAUACUG:

NamemiRBase Accession
hsa-miR-200b-3p MIMAT0000318
hsa-miR-200c-3p MIMAT0000617
hsa-miR-429 MIMAT0001536



Activity profile for motif AAUACUG.

activity profile for motif AAUACUG


Sorted Z-values histogram for motif AAUACUG

Sorted Z-values for motif AAUACUG



Network of associatons between targets according to the STRING database.



First level regulatory network of AAUACUG

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_5632436 4.140 ENST00000340250.6
ENST00000382361.3
 FSCN1

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

chrX_+_64887512 3.884 ENST00000360270.5
 MSN
moesin
chr10_+_102106829 3.717 ENST00000370355.2
 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr6_-_30654977 3.437 ENST00000399199.3
 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr7_-_41742697 3.436 ENST00000242208.4
 INHBA
inhibin, beta A
chr2_+_210444142 2.798 ENST00000360351.4
ENST00000361559.4
 MAP2

microtubule-associated protein 2

chr7_+_36429409 2.517 ENST00000265748.2
 ANLN
anillin, actin binding protein
chr13_-_30881621 2.447 ENST00000380615.3
 KATNAL1
katanin p60 subunit A-like 1
chr9_+_34990219 2.345 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
 DNAJB5


DnaJ (Hsp40) homolog, subfamily B, member 5


chr12_+_1800179 2.285 ENST00000357103.4
 ADIPOR2
adiponectin receptor 2
chr21_-_16437255 2.229 ENST00000400199.1
ENST00000400202.1
 NRIP1

nuclear receptor interacting protein 1

chr1_+_182992545 2.218 ENST00000258341.4
 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr1_+_84543734 2.159 ENST00000370689.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr18_-_21166841 2.087 ENST00000269228.5
 NPC1
Niemann-Pick disease, type C1
chr2_+_11886710 1.928 ENST00000256720.2
ENST00000441684.1
ENST00000423495.1
 LPIN1


lipin 1


chr1_+_178694300 1.873 ENST00000367635.3
 RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr11_-_119599794 1.849 ENST00000264025.3
 PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr3_-_98620500 1.820 ENST00000326840.6
 DCBLD2
discoidin, CUB and LCCL domain containing 2
chr1_+_201252580 1.763 ENST00000367324.3
ENST00000263946.3
 PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr14_-_35182994 1.737 ENST00000341223.3
 CFL2
cofilin 2 (muscle)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 248 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 GO:0070831 basement membrane assembly(GO:0070831)
0.7 4.1 GO:0030035 microspike assembly(GO:0030035)
0.6 3.9 GO:0022614 membrane to membrane docking(GO:0022614)
1.2 3.7 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
1.1 3.4 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 2.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 2.6 GO:0006986 response to unfolded protein(GO:0006986)
0.8 2.5 GO:1904170 regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.3 2.4 GO:0051013 microtubule severing(GO:0051013)
0.6 2.3 GO:0003169 coronary vein morphogenesis(GO:0003169)
0.3 2.3 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 2.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.3 2.2 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.2 2.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 2.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 2.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.5 1.9 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.3 1.9 GO:0006642 triglyceride mobilization(GO:0006642)
0.2 1.9 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0 1.9 GO:0006695 cholesterol biosynthetic process(GO:0006695)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.1 GO:0044393 microspike(GO:0044393)
0.3 3.9 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 3.8 GO:0016600 flotillin complex(GO:0016600)
0.0 3.6 GO:0001726 ruffle(GO:0001726)
1.1 3.4 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.7 2.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 2.7 GO:0030027 lamellipodium(GO:0030027)
0.0 2.6 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.5 2.5 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 2.4 GO:0031902 late endosome membrane(GO:0031902)
0.6 2.2 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
0.0 2.2 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 1.6 GO:0035580 specific granule lumen(GO:0035580)
0.0 1.5 GO:0002102 podosome(GO:0002102)
0.0 1.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.4 1.3 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.1 1.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 1.3 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0051015 actin filament binding(GO:0051015)
0.0 3.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 3.8 GO:0051087 chaperone binding(GO:0051087)
0.7 3.7 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 3.6 GO:0019902 phosphatase binding(GO:0019902)
1.1 3.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 3.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 3.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 2.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.3 2.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 2.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 2.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 2.1 GO:0015248 sterol transporter activity(GO:0015248)
0.0 2.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.5 1.9 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 1.8 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 1.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 1.7 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 4.3 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 3.9 PID_LKB1_PATHWAY LKB1 signaling events
0.0 3.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 2.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 2.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.2 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 2.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.2 PID_EPO_PATHWAY EPO signaling pathway
0.0 2.2 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 2.0 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.8 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.5 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 1.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 1.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.2 3.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 3.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.3 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 3.2 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1 2.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.9 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 1.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.8 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.1 1.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE
0.0 1.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.7 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.4 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.4 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 1.4 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.3 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.2 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway