Motif ID: ACAGUAU

Z-value: 0.571


Mature miRNA associated with seed ACAGUAU:

NamemiRBase Accession
hsa-miR-144-3p MIMAT0000436



Activity profile for motif ACAGUAU.

activity profile for motif ACAGUAU


Sorted Z-values histogram for motif ACAGUAU

Sorted Z-values for motif ACAGUAU



Network of associatons between targets according to the STRING database.



First level regulatory network of ACAGUAU

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_17281573 1.273 ENST00000379052.5
 RBM24
RNA binding motif protein 24
chr9_-_3525968 1.130 ENST00000382004.3
ENST00000302303.1
ENST00000449190.1
 RFX3


regulatory factor X, 3 (influences HLA class II expression)


chr6_+_107811162 0.954 ENST00000317357.5
 SOBP
sine oculis binding protein homolog (Drosophila)
chr8_+_136469684 0.876 ENST00000355849.5
 KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr17_+_14204389 0.868 ENST00000360954.2
 HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr1_-_217262969 0.852 ENST00000361525.3
 ESRRG
estrogen-related receptor gamma
chr11_-_115375107 0.802 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
 CADM1





cell adhesion molecule 1





chr10_-_46167722 0.774 ENST00000374366.3
ENST00000344646.5
 ZFAND4

zinc finger, AN1-type domain 4

chr15_-_48470558 0.737 ENST00000324324.7
 MYEF2
myelin expression factor 2
chr7_-_131241361 0.719 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
 PODXL



podocalyxin-like



chr8_+_75896731 0.678 ENST00000262207.4
 CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr17_+_55333876 0.677 ENST00000284073.2
 MSI2
musashi RNA-binding protein 2
chr6_+_135502466 0.657 ENST00000367814.4
 MYB
v-myb avian myeloblastosis viral oncogene homolog
chr5_-_38595498 0.644 ENST00000263409.4
 LIFR
leukemia inhibitory factor receptor alpha
chr1_-_173991434 0.640 ENST00000367696.2
 RC3H1
ring finger and CCCH-type domains 1
chr3_+_3841108 0.625 ENST00000319331.3
 LRRN1
leucine rich repeat neuronal 1
chr1_+_244214577 0.601 ENST00000358704.4
 ZBTB18
zinc finger and BTB domain containing 18
chr22_+_29279552 0.577 ENST00000544604.2
 ZNRF3
zinc and ring finger 3
chr18_-_45663666 0.558 ENST00000535628.2
 ZBTB7C
zinc finger and BTB domain containing 7C
chr6_+_122720681 0.544 ENST00000368455.4
ENST00000452194.1
 HSF2

heat shock transcription factor 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0090102 cochlea development(GO:0090102)
0.0 1.2 GO:0010830 regulation of myotube differentiation(GO:0010830)
0.4 1.1 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.2 0.9 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 0.8 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.7 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 0.7 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.6 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.1 0.6 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.6 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.6 GO:0060325 face morphogenesis(GO:0060325)
0.2 0.5 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 0.5 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.2 0.5 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 0.5 GO:0070662 mast cell proliferation(GO:0070662)
0.0 0.5 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.5 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0 0.5 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.5 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.0 0.6 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.2 0.5 GO:0018444 translation release factor complex(GO:0018444)
0.1 0.4 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.2 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:1990812 growth cone filopodium(GO:1990812)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 1.0 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.9 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 0.6 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.1 0.6 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.6 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.1 0.5 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.4 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.1 0.4 GO:0031862 prostanoid receptor binding(GO:0031862)
0.1 0.4 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.4 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.3 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.2 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.1 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.1 PID_S1P_S1P2_PATHWAY S1P2 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.0 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events