Motif ID: AGCAGCA

Z-value: 0.554


Mature miRNA associated with seed AGCAGCA:

NamemiRBase Accession
hsa-miR-15a-5p MIMAT0000068
hsa-miR-15b-5p MIMAT0000417
hsa-miR-16-5p MIMAT0000069
hsa-miR-195-5p MIMAT0000461
hsa-miR-424-5p MIMAT0001341
hsa-miR-497-5p MIMAT0002820
hsa-miR-6838-5p MIMAT0027578



Activity profile for motif AGCAGCA.

activity profile for motif AGCAGCA


Sorted Z-values histogram for motif AGCAGCA

Sorted Z-values for motif AGCAGCA



Network of associatons between targets according to the STRING database.



First level regulatory network of AGCAGCA

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_4382917 0.808 ENST00000261254.3
 CCND2
cyclin D2
chr9_+_17579084 0.685 ENST00000380607.4
 SH3GL2
SH3-domain GRB2-like 2
chr4_-_111119804 0.432 ENST00000394607.3
ENST00000302274.3
 ELOVL6

ELOVL fatty acid elongase 6

chr2_-_208030647 0.396 ENST00000309446.6
 KLF7
Kruppel-like factor 7 (ubiquitous)
chr17_-_80056099 0.391 ENST00000306749.2
 FASN
fatty acid synthase
chr11_-_119599794 0.357 ENST00000264025.3
 PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr14_-_105420241 0.336 ENST00000557457.1
 AHNAK2
AHNAK nucleoprotein 2
chr1_-_22263790 0.321 ENST00000374695.3
 HSPG2
heparan sulfate proteoglycan 2
chr2_-_122042770 0.320 ENST00000263707.5
 TFCP2L1
transcription factor CP2-like 1
chr15_+_67358163 0.292 ENST00000327367.4
 SMAD3
SMAD family member 3
chr15_+_41245160 0.292 ENST00000444189.2
ENST00000446533.3
 CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr3_+_47324424 0.282 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
 KLHL18


kelch-like family member 18


chr2_-_72375167 0.282 ENST00000001146.2
 CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr2_+_110371905 0.281 ENST00000356454.3
 SOWAHC
sosondowah ankyrin repeat domain family member C
chr10_+_88718397 0.259 ENST00000372017.3
 SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr3_-_13921594 0.246 ENST00000285018.4
 WNT7A
wingless-type MMTV integration site family, member 7A
chr2_+_26568965 0.244 ENST00000260585.7
ENST00000447170.1
 EPT1

ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)

chr6_+_43737939 0.243 ENST00000372067.3
 VEGFA
vascular endothelial growth factor A
chr11_-_34379546 0.243 ENST00000435224.2
 ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr19_-_51141196 0.243 ENST00000338916.4
 SYT3
synaptotagmin III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 0.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.6 GO:0007028 cytoplasm organization(GO:0007028)
0.1 0.4 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.0 0.4 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.4 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.3 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 0.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.3 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.3 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.2 GO:0031133 regulation of axon diameter(GO:0031133)
0.1 0.2 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1 0.2 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.2 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 0.2 GO:1904647 response to rotenone(GO:1904647)
0.1 0.2 GO:1902534 single-organism membrane invagination(GO:1902534)
0.0 0.2 GO:0031064 negative regulation of histone deacetylation(GO:0031064)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.4 GO:0035838 growing cell tip(GO:0035838)
0.0 0.4 GO:0042587 glycogen granule(GO:0042587)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.2 GO:0044308 axonal spine(GO:0044308)
0.0 0.2 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.2 GO:0042588 zymogen granule(GO:0042588)
0.0 0.1 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.0 0.1 GO:0035370 UBC13-UEV1A complex(GO:0035370)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.4 GO:0031177 S-acetyltransferase activity(GO:0016418) phosphopantetheine binding(GO:0031177)
0.1 0.4 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.0 0.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 0.3 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.2 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 0.2 GO:0030305 heparanase activity(GO:0030305)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0035501 MH1 domain binding(GO:0035501)
0.0 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.2 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.4 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.1 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.6 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.5 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.3 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.0 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains