Motif ID: AGCUGCC

Z-value: 0.431


Mature miRNA associated with seed AGCUGCC:

NamemiRBase Accession
hsa-miR-22-3p MIMAT0000077



Activity profile for motif AGCUGCC.

activity profile for motif AGCUGCC


Sorted Z-values histogram for motif AGCUGCC

Sorted Z-values for motif AGCUGCC



Network of associatons between targets according to the STRING database.



First level regulatory network of AGCUGCC

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_125133315 0.445 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr5_-_100238956 0.378 ENST00000231461.5
 ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr5_-_146833485 0.360 ENST00000398514.3
 DPYSL3
dihydropyrimidinase-like 3
chr1_-_244013384 0.342 ENST00000366539.1
 AKT3
v-akt murine thymoma viral oncogene homolog 3
chr5_-_127873659 0.317 ENST00000262464.4
 FBN2
fibrillin 2
chr17_-_16256718 0.300 ENST00000476243.1
ENST00000299736.4
 CENPV

centromere protein V

chr19_-_46234119 0.293 ENST00000317683.3
 FBXO46
F-box protein 46
chr12_+_93965451 0.276 ENST00000548537.1
 SOCS2
suppressor of cytokine signaling 2
chr22_+_38071615 0.270 ENST00000215909.5
 LGALS1
lectin, galactoside-binding, soluble, 1
chr1_+_26438289 0.263 ENST00000374271.4
ENST00000374269.1
 PDIK1L

PDLIM1 interacting kinase 1 like

chr16_+_10971037 0.255 ENST00000324288.8
ENST00000381835.5
 CIITA

class II, major histocompatibility complex, transactivator

chr10_+_69644404 0.241 ENST00000212015.6
 SIRT1
sirtuin 1
chr1_-_63988846 0.240 ENST00000283568.8
ENST00000371092.3
ENST00000271002.10
 ITGB3BP


integrin beta 3 binding protein (beta3-endonexin)


chr11_-_95657231 0.230 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
 MTMR2



myotubularin related protein 2



chr1_+_184356188 0.228 ENST00000235307.6
 C1orf21
chromosome 1 open reading frame 21
chr5_-_159739532 0.219 ENST00000520748.1
ENST00000393977.3
ENST00000257536.7
 CCNJL


cyclin J-like


chr11_-_115375107 0.213 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
 CADM1





cell adhesion molecule 1





chr7_+_73703728 0.204 ENST00000361545.5
ENST00000223398.6
 CLIP2

CAP-GLY domain containing linker protein 2

chr5_+_57878859 0.202 ENST00000282878.4
 RAB3C
RAB3C, member RAS oncogene family
chr10_+_89622870 0.197 ENST00000371953.3
 PTEN
phosphatase and tensin homolog

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.3 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.3 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0 0.3 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 0.2 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.1 0.2 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.2 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.1 0.2 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.1 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.2 GO:0060061 Spemann organizer formation(GO:0060061) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183)
0.0 0.2 GO:1903984 negative regulation of ribosome biogenesis(GO:0090071) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.2 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.0 0.2 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.0 0.2 GO:0071877 regulation of adrenergic receptor signaling pathway(GO:0071877)
0.0 0.1 GO:1903410 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.0 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.0 GO:0098855 HCN channel complex(GO:0098855)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.3 GO:0030395 lactose binding(GO:0030395)
0.0 0.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.3 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.2 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.2 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0016015 morphogen activity(GO:0016015)
0.0 0.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.1 GO:0005289 high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.2 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Genes involved in NRIF signals cell death from the nucleus