Motif ID: AGCUUAU

Z-value: 0.292


Mature miRNA associated with seed AGCUUAU:

NamemiRBase Accession
hsa-miR-21-5p MIMAT0000076
hsa-miR-590-5p MIMAT0003258



Activity profile for motif AGCUUAU.

activity profile for motif AGCUUAU


Sorted Z-values histogram for motif AGCUUAU

Sorted Z-values for motif AGCUUAU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGCUUAU

PNG image of the network

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Top targets:


Showing 1 to 20 of 157 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_33197683 0.558 ENST00000266085.6
 TIMP3
TIMP metallopeptidase inhibitor 3
chr1_+_178694300 0.408 ENST00000367635.3
 RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr11_-_115375107 0.346 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
 CADM1





cell adhesion molecule 1





chr8_-_10697281 0.294 ENST00000553390.1
ENST00000524114.1
ENST00000554914.1
 SOX7
PINX1
SOX7
SRY (sex determining region Y)-box 7
PIN2/TERF1 interacting, telomerase inhibitor 1
Transcription factor SOX-7; Uncharacterized protein; cDNA FLJ58508, highly similar to Transcription factor SOX-7
chr11_+_12308447 0.273 ENST00000256186.2
 MICALCL
MICAL C-terminal like
chr2_+_228678550 0.239 ENST00000409189.3
ENST00000358813.4
 CCL20

chemokine (C-C motif) ligand 20

chr8_-_82024290 0.227 ENST00000220597.4
 PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr21_-_32931290 0.225 ENST00000286827.3
 TIAM1
T-cell lymphoma invasion and metastasis 1
chr11_-_64646086 0.222 ENST00000320631.3
 EHD1
EH-domain containing 1
chr8_-_10588010 0.196 ENST00000304501.1
 SOX7
SRY (sex determining region Y)-box 7
chr17_-_33448468 0.183 ENST00000587405.1
ENST00000591723.1
ENST00000593039.1
 RAD51D
RAD51L3-RFFL

RAD51 paralog D
Uncharacterized protein

chrX_+_100805496 0.178 ENST00000372829.3
 ARMCX1
armadillo repeat containing, X-linked 1
chr17_+_17942594 0.177 ENST00000268719.4
 GID4
GID complex subunit 4
chr1_+_2160134 0.176 ENST00000378536.4
 SKI
v-ski avian sarcoma viral oncogene homolog
chr5_+_135364584 0.166 ENST00000442011.2
ENST00000305126.8
 TGFBI

transforming growth factor, beta-induced, 68kDa

chr2_-_64371546 0.164 ENST00000358912.4
 PELI1
pellino E3 ubiquitin protein ligase 1
chr20_-_23030296 0.156 ENST00000377103.2
 THBD
thrombomodulin
chr10_+_98741041 0.141 ENST00000286067.2
 C10orf12
chromosome 10 open reading frame 12
chr4_-_89744457 0.127 ENST00000395002.2
 FAM13A
family with sequence similarity 13, member A
chr10_+_112631547 0.123 ENST00000280154.7
ENST00000393104.2
 PDCD4

programmed cell death 4 (neoplastic transformation inhibitor)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.6 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.4 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.1 0.3 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.3 GO:1904751 positive regulation of telomeric DNA binding(GO:1904744) positive regulation of protein localization to nucleolus(GO:1904751)
0.1 0.2 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 0.2 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.0 0.2 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
0.0 0.2 GO:1903977 positive regulation of glial cell migration(GO:1903977)
0.0 0.2 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.2 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 0.1 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.1 GO:0046495 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.0 0.1 GO:0002860 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.1 GO:0048880 sensory system development(GO:0048880)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.1 GO:0070110 ciliary neurotrophic factor receptor complex(GO:0070110)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)

Gene overrepresentation in molecular_function category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.3 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 0.2 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0098808 mRNA cap binding(GO:0098808)
0.0 0.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.0 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.0 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.0 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex