Motif ID: AGUGCUU

Z-value: 0.572


Mature miRNA associated with seed AGUGCUU:

NamemiRBase Accession
hsa-miR-302c-3p.2
hsa-miR-520f-3p MIMAT0002830



Activity profile for motif AGUGCUU.

activity profile for motif AGUGCUU


Sorted Z-values histogram for motif AGUGCUU

Sorted Z-values for motif AGUGCUU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGUGCUU

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_72375167 2.083 ENST00000001146.2
 CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr12_+_4382917 2.049 ENST00000261254.3
 CCND2
cyclin D2
chr17_+_70117153 1.536 ENST00000245479.2
 SOX9
SRY (sex determining region Y)-box 9
chr2_-_208030647 1.471 ENST00000309446.6
 KLF7
Kruppel-like factor 7 (ubiquitous)
chr20_+_3776371 1.380 ENST00000245960.5
 CDC25B
cell division cycle 25B
chr1_-_20812690 1.375 ENST00000375078.3
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr2_+_174219548 1.340 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
 CDCA7




cell division cycle associated 7




chr7_-_41742697 1.024 ENST00000242208.4
 INHBA
inhibin, beta A
chr2_-_235405679 0.991 ENST00000390645.2
 ARL4C
ADP-ribosylation factor-like 4C
chr21_-_44846999 0.963 ENST00000270162.6
 SIK1
salt-inducible kinase 1
chr4_-_111119804 0.952 ENST00000394607.3
ENST00000302274.3
 ELOVL6

ELOVL fatty acid elongase 6

chr3_+_47324424 0.862 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
 KLHL18


kelch-like family member 18


chr9_-_99180597 0.860 ENST00000375256.4
 ZNF367
zinc finger protein 367
chr14_-_35182994 0.854 ENST00000341223.3
 CFL2
cofilin 2 (muscle)
chr12_+_56915713 0.830 ENST00000262031.5
ENST00000552247.2
 RBMS2

RNA binding motif, single stranded interacting protein 2

chr15_-_91537723 0.767 ENST00000394249.3
ENST00000559811.1
ENST00000442656.2
ENST00000557905.1
ENST00000361919.3
 PRC1




protein regulator of cytokinesis 1




chr1_+_178694300 0.760 ENST00000367635.3
 RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr18_+_21269404 0.723 ENST00000313654.9
 LAMA3
laminin, alpha 3
chr9_+_137218362 0.703 ENST00000481739.1
 RXRA
retinoid X receptor, alpha
chr2_+_110371905 0.681 ENST00000356454.3
 SOWAHC
sosondowah ankyrin repeat domain family member C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.1 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 2.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.5 1.5 GO:0060516 primary prostatic bud elongation(GO:0060516) renal vesicle induction(GO:0072034)
0.1 1.4 GO:0007144 female meiosis I(GO:0007144)
0.3 1.0 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 1.0 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.1 1.0 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.1 1.0 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 1.0 GO:0032456 endocytic recycling(GO:0032456)
0.1 0.9 GO:0030043 actin filament fragmentation(GO:0030043)
0.2 0.8 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.1 0.8 GO:0000022 mitotic spindle elongation(GO:0000022)
0.2 0.7 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.1 0.7 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.7 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 0.6 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.1 0.6 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.1 0.6 GO:0071321 cellular response to cGMP(GO:0071321)
0.1 0.6 GO:0060979 vasculogenesis involved in coronary vascular morphogenesis(GO:0060979)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.0 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 1.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.1 GO:0005901 caveola(GO:0005901)
0.3 1.0 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.8 GO:0070938 contractile ring(GO:0070938)
0.1 0.7 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.6 GO:0000811 GINS complex(GO:0000811)
0.1 0.6 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.6 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.5 GO:0070695 FHF complex(GO:0070695)
0.0 0.5 GO:0016600 flotillin complex(GO:0016600)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 0.4 GO:0098855 HCN channel complex(GO:0098855)
0.1 0.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 2.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 1.5 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.5 1.4 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.3 1.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 1.0 GO:0038025 reelin receptor activity(GO:0038025)
0.1 1.0 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 1.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 0.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.7 GO:0019894 kinesin binding(GO:0019894)
0.2 0.6 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.2 0.6 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.6 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.6 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.6 GO:0004629 phospholipase C activity(GO:0004629)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 1.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.1 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.7 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.3 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 2.1 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.5 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation