Motif ID: AGUGGUU

Z-value: 0.710


Mature miRNA associated with seed AGUGGUU:

NamemiRBase Accession
hsa-miR-140-5p MIMAT0000431



Activity profile for motif AGUGGUU.

activity profile for motif AGUGGUU


Sorted Z-values histogram for motif AGUGGUU

Sorted Z-values for motif AGUGGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGUGGUU

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_81071684 1.486 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
 KIAA1199


KIAA1199


chr14_+_85996471 1.476 ENST00000330753.4
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_-_20812690 1.439 ENST00000375078.3
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr9_+_131174024 1.413 ENST00000420034.1
ENST00000372842.1
 CERCAM

cerebral endothelial cell adhesion molecule

chr20_+_6748311 1.290 ENST00000378827.4
 BMP2
bone morphogenetic protein 2
chr5_-_127873659 1.259 ENST00000262464.4
 FBN2
fibrillin 2
chr1_+_178694300 0.944 ENST00000367635.3
 RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr7_-_98741642 0.927 ENST00000361368.2
 SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr8_+_26435359 0.912 ENST00000311151.5
 DPYSL2
dihydropyrimidinase-like 2
chr19_-_2096259 0.908 ENST00000588048.1
ENST00000357066.3
 MOB3A

MOB kinase activator 3A

chr17_-_33448468 0.901 ENST00000587405.1
ENST00000591723.1
ENST00000593039.1
 RAD51D
RAD51L3-RFFL

RAD51 paralog D
Uncharacterized protein

chr1_+_182992545 0.893 ENST00000258341.4
 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr7_+_2671568 0.891 ENST00000258796.7
 TTYH3
tweety family member 3
chr1_-_109825719 0.879 ENST00000369904.3
ENST00000369903.2
ENST00000429031.1
ENST00000418914.2
ENST00000409267.1
 PSRC1




proline/serine-rich coiled-coil 1




chr2_+_48541776 0.846 ENST00000413569.1
ENST00000340553.3
 FOXN2

forkhead box N2

chr5_-_77844974 0.834 ENST00000515007.2
 LHFPL2
lipoma HMGIC fusion partner-like 2
chr14_+_65171099 0.833 ENST00000247226.7
 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_+_11994715 0.818 ENST00000449038.1
ENST00000376369.3
ENST00000429000.2
ENST00000196061.4
 PLOD1



procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1



chr9_+_112810878 0.750 ENST00000434623.2
ENST00000374525.1
 AKAP2

A kinase (PRKA) anchor protein 2

chr6_+_43737939 0.750 ENST00000372067.3
 VEGFA
vascular endothelial growth factor A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.4 1.3 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.1 1.3 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.3 0.9 GO:1902534 single-organism membrane invagination(GO:1902534)
0.1 0.9 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.9 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.9 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.3 0.8 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.8 GO:0006907 pinocytosis(GO:0006907)
0.2 0.7 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.2 0.7 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.1 0.7 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 0.6 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 0.6 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.6 GO:1905167 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 0.6 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 0.6 GO:0060979 vasculogenesis involved in coronary vascular morphogenesis(GO:0060979)
0.1 0.6 GO:1903923 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.1 0.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 0.5 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 1.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 0.9 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
0.1 0.9 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.8 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.8 GO:0005876 spindle microtubule(GO:0005876)
0.2 0.6 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.1 0.6 GO:0005826 actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513)
0.0 0.6 GO:0016600 flotillin complex(GO:0016600)
0.1 0.4 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0045499 chemorepellent activity(GO:0045499)
0.5 1.4 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 1.3 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 1.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 1.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.3 0.9 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.9 GO:0000150 recombinase activity(GO:0000150)
0.1 0.9 GO:0048185 activin binding(GO:0048185)
0.0 0.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 0.8 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.2 0.7 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.2 0.7 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.2 0.6 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 0.5 GO:0030984 kininogen binding(GO:0030984)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.4 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.3 PID_CONE_PATHWAY Visual signal transduction: Cones

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.9 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.6 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.4 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)