Motif ID: AHR_ARNT2

Z-value: 1.178

Transcription factors associated with AHR_ARNT2:

Gene SymbolEntrez IDGene Name
AHR ENSG00000106546.8 AHR
ARNT2 ENSG00000172379.14 ARNT2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ARNT2hg19_v2_chr15_+_80696666_80696700,
hg19_v2_chr15_+_80733570_80733659		-0.718.8e-05Click!
AHRhg19_v2_chr7_+_17338239_173382620.639.7e-04Click!


Activity profile for motif AHR_ARNT2.

activity profile for motif AHR_ARNT2


Sorted Z-values histogram for motif AHR_ARNT2

Sorted Z-values for motif AHR_ARNT2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_55672037 4.581 ENST00000588076.1
 DNAAF3
dynein, axonemal, assembly factor 3
chr16_+_777118 4.268 ENST00000562141.1
 HAGHL
hydroxyacylglutathione hydrolase-like
chr18_-_71815051 3.780 ENST00000582526.1
ENST00000419743.2
 FBXO15

F-box protein 15

chr16_-_776431 3.602 ENST00000293889.6
 CCDC78
coiled-coil domain containing 78
chr18_-_71814999 3.578 ENST00000269500.5
 FBXO15
F-box protein 15
chr7_-_73184588 3.494 ENST00000395145.2
 CLDN3
claudin 3
chr3_+_49449636 3.204 ENST00000273590.3
 TCTA
T-cell leukemia translocation altered
chr11_+_61276214 3.135 ENST00000378075.2
 LRRC10B
leucine rich repeat containing 10B
chr6_-_90121789 2.777 ENST00000359203.3
 RRAGD
Ras-related GTP binding D
chr7_-_154863264 2.546 ENST00000395731.2
ENST00000543018.1
 HTR5A-AS1

HTR5A antisense RNA 1

chr1_-_223537475 2.541 ENST00000344029.6
ENST00000494793.2
ENST00000366878.4
ENST00000366877.3
 SUSD4



sushi domain containing 4



chr6_-_90121938 2.499 ENST00000369415.4
 RRAGD
Ras-related GTP binding D
chr10_+_104178946 2.496 ENST00000432590.1
 FBXL15
F-box and leucine-rich repeat protein 15
chr1_+_227127981 2.367 ENST00000366778.1
ENST00000366777.3
ENST00000458507.2
 ADCK3


aarF domain containing kinase 3


chr17_+_260097 2.303 ENST00000360127.6
ENST00000571106.1
ENST00000491373.1
 C17orf97


chromosome 17 open reading frame 97


chr4_-_168155730 2.291 ENST00000502330.1
ENST00000357154.3
 SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr6_+_126070726 2.280 ENST00000368364.3
 HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr5_-_159739532 2.263 ENST00000520748.1
ENST00000393977.3
ENST00000257536.7
 CCNJL


cyclin J-like


chr22_-_39548627 2.247 ENST00000216133.5
 CBX7
chromobox homolog 7
chr6_+_163148973 2.228 ENST00000366888.2
 PACRG
PARK2 co-regulated

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 616 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 8.1 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.3 6.2 GO:0072189 ureter development(GO:0072189)
0.7 5.3 GO:0071233 cellular response to leucine(GO:0071233)
0.0 5.3 GO:0000209 protein polyubiquitination(GO:0000209)
1.6 4.7 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.4 4.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 4.6 GO:0030449 regulation of complement activation(GO:0030449)
0.1 3.8 GO:0031016 pancreas development(GO:0031016)
0.1 3.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.7 3.6 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.5 3.4 GO:0098535 de novo centriole assembly(GO:0098535)
0.6 3.3 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0 3.0 GO:0048515 spermatid differentiation(GO:0048515)
0.1 2.9 GO:0007220 Notch receptor processing(GO:0007220)
0.6 2.6 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.6 2.6 GO:0000255 allantoin metabolic process(GO:0000255)
0.2 2.6 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.1 2.5 GO:0070314 G1 to G0 transition(GO:0070314)
0.3 2.4 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.9 5.3 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.9 4.4 GO:0005879 axonemal microtubule(GO:0005879)
0.1 4.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.7 3.7 GO:0098536 deuterosome(GO:0098536)
0.1 3.4 GO:0097546 ciliary base(GO:0097546)
0.1 3.3 GO:0016580 Sin3 complex(GO:0016580)
0.1 3.2 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 3.1 GO:0031514 motile cilium(GO:0031514)
0.0 3.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.4 2.7 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 2.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 2.5 GO:0031901 early endosome membrane(GO:0031901)
0.1 2.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.3 GO:0005871 kinesin complex(GO:0005871)
0.0 2.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2 2.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.7 2.0 GO:0070195 growth hormone receptor complex(GO:0070195)
0.6 1.9 GO:0097598 sperm cytoplasmic droplet(GO:0097598)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 381 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.7 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 12.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 10.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 6.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 4.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 4.5 GO:0019003 GDP binding(GO:0019003)
0.0 3.9 GO:0003777 microtubule motor activity(GO:0003777)
0.7 2.8 GO:0035939 microsatellite binding(GO:0035939)
0.4 2.7 GO:0004127 cytidylate kinase activity(GO:0004127)
0.2 2.6 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 2.6 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.4 2.5 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 2.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.8 2.4 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 2.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 2.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 2.3 GO:0008301 DNA binding, bending(GO:0008301)
0.1 2.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 2.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.2 2.0 GO:0070700 BMP receptor binding(GO:0070700)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 8.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 7.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 3.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 3.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 2.2 PID_MYC_PATHWAY C-MYC pathway
0.0 2.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.5 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.1 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.9 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 6.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 5.9 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ Genes involved in Cyclin E associated events during G1/S transition
0.1 3.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 3.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.8 REACTOME_KINESINS Genes involved in Kinesins
0.0 2.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.7 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 1.5 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 1.3 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation