Motif ID: AIRE

Z-value: 0.589


Transcription factors associated with AIRE:

Gene SymbolEntrez IDGene Name
AIRE ENSG00000160224.12 AIRE

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
AIREhg19_v2_chr21_+_45705752_457057670.414.9e-02Click!


Activity profile for motif AIRE.

activity profile for motif AIRE


Sorted Z-values histogram for motif AIRE

Sorted Z-values for motif AIRE



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE

PNG image of the network

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Top targets:


Showing 1 to 20 of 185 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_57524061 1.950 ENST00000508121.1
 HOPX
HOP homeobox
chr12_-_25101920 1.339 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr8_+_54764346 1.156 ENST00000297313.3
ENST00000344277.6
 RGS20

regulator of G-protein signaling 20

chr21_-_44495919 0.914 ENST00000398158.1
 CBS
cystathionine-beta-synthase
chr12_+_75874984 0.872 ENST00000550491.1
 GLIPR1
GLI pathogenesis-related 1
chr14_-_55658323 0.809 ENST00000554067.1
ENST00000247191.2
 DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr14_-_55658252 0.808 ENST00000395425.2
 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr21_-_44495964 0.803 ENST00000398168.1
ENST00000398165.3
 CBS

cystathionine-beta-synthase

chr21_+_30502806 0.793 ENST00000399928.1
ENST00000399926.1
 MAP3K7CL

MAP3K7 C-terminal like

chr20_+_44637526 0.788 ENST00000372330.3
 MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr12_+_75874580 0.773 ENST00000456650.3
 GLIPR1
GLI pathogenesis-related 1
chr1_+_165864821 0.771 ENST00000470820.1
 UCK2
uridine-cytidine kinase 2
chr21_+_39644214 0.770 ENST00000438657.1
 KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr16_+_11439286 0.759 ENST00000312499.5
ENST00000576027.1
 RMI2

RecQ mediated genome instability 2

chr21_+_39644305 0.751 ENST00000398930.1
 KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr21_+_39644172 0.725 ENST00000398932.1
 KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_+_35211511 0.719 ENST00000524922.1
 CD44
CD44 molecule (Indian blood group)
chr21_+_39644395 0.714 ENST00000398934.1
 KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr4_-_104119528 0.713 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
 CENPE


centromere protein E, 312kDa


chr17_+_7210294 0.699 ENST00000336452.7
 EIF5A
eukaryotic translation initiation factor 5A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0010107 potassium ion import(GO:0010107)
0.4 2.3 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 1.9 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.6 1.7 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.0 1.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 1.3 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.3 1.2 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.0 0.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 0.8 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 0.8 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.0 0.8 GO:0000732 strand displacement(GO:0000732)
0.1 0.7 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.7 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.4 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.4 GO:1901725 regulation of histone deacetylase activity(GO:1901725)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 1.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.7 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.7 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.1 0.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0060091 kinocilium(GO:0060091)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.6 1.7 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.0 1.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 1.3 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 1.2 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.8 GO:0004882 androgen receptor activity(GO:0004882)
0.1 0.8 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.7 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 0.6 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.4 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.3 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.5 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 1.2 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.5 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.3 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.2 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.3 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins