Motif ID: ALX1_ARX

Z-value: 0.406

Transcription factors associated with ALX1_ARX:

Gene SymbolEntrez IDGene Name
ALX1 ENSG00000180318.3 ALX1
ARX ENSG00000004848.6 ARX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ARXhg19_v2_chrX_-_25034065_25034088-0.331.2e-01Click!
ALX1hg19_v2_chr12_+_85673868_85673885-0.086.9e-01Click!


Activity profile for motif ALX1_ARX.

activity profile for motif ALX1_ARX


Sorted Z-values histogram for motif ALX1_ARX

Sorted Z-values for motif ALX1_ARX



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1_ARX

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_102413726 0.889 ENST00000350878.4
 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr1_+_50569575 0.797 ENST00000371827.1
 ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr6_+_34204642 0.770 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
 HMGA1




high mobility group AT-hook 1




chr4_+_69313145 0.581 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr17_+_39261584 0.546 ENST00000391415.1
 KRTAP4-9
keratin associated protein 4-9
chr14_-_95236551 0.538 ENST00000238558.3
 GSC
goosecoid homeobox
chr1_+_84630645 0.475 ENST00000394839.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_-_93520259 0.462 ENST00000222543.5
 TFPI2
tissue factor pathway inhibitor 2
chr3_-_141747950 0.459 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_-_94147385 0.455 ENST00000260502.6
 BCAR3
breast cancer anti-estrogen resistance 3
chr4_+_169013666 0.443 ENST00000359299.3
 ANXA10
annexin A10
chr10_-_75226166 0.414 ENST00000544628.1
 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr7_-_93520191 0.393 ENST00000545378.1
 TFPI2
tissue factor pathway inhibitor 2
chr1_-_151148492 0.375 ENST00000295314.4
 TMOD4
tropomodulin 4 (muscle)
chr1_-_151148442 0.362 ENST00000441701.1
ENST00000416280.2
 TMOD4

tropomodulin 4 (muscle)

chr10_+_69865866 0.361 ENST00000354393.2
 MYPN
myopalladin
chr8_-_10512569 0.359 ENST00000382483.3
 RP1L1
retinitis pigmentosa 1-like 1
chr2_-_145278475 0.352 ENST00000558170.2
 ZEB2
zinc finger E-box binding homeobox 2
chr12_-_89746173 0.335 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr8_-_122653630 0.322 ENST00000303924.4
 HAS2
hyaluronan synthase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.9 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.2 0.8 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.7 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.6 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.2 0.5 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.5 GO:0097338 response to clozapine(GO:0097338)
0.0 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.5 GO:0042461 photoreceptor cell development(GO:0042461)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.4 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.4 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.3 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.3 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.3 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.3 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.0 0.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.3 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.2 GO:1990032 parallel fiber(GO:1990032)
0.1 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.1 GO:1990357 terminal web(GO:1990357)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.8 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.3 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.2 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.1 0.2 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.2 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.2 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.2 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.3 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling