Motif ID: ALX3

Z-value: 0.605


Transcription factors associated with ALX3:

Gene SymbolEntrez IDGene Name
ALX3 ENSG00000156150.6 ALX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ALX3hg19_v2_chr1_-_110613276_110613322-0.341.1e-01Click!


Activity profile for motif ALX3.

activity profile for motif ALX3


Sorted Z-values histogram for motif ALX3

Sorted Z-values for motif ALX3



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_25348007 2.702 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
CASC1






cancer susceptibility candidate 1






chr5_-_35938674 2.265 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL



calcyphosine-like



chr11_+_101918153 2.244 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
C11orf70


chromosome 11 open reading frame 70


chr12_+_7013897 2.098 ENST00000007969.8
ENST00000323702.5
LRRC23

leucine rich repeat containing 23

chr12_+_7014064 2.070 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr11_-_63376013 1.606 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr12_-_10282836 1.576 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A


C-type lectin domain family 7, member A


chr16_-_55866997 1.496 ENST00000360526.3
ENST00000361503.4
CES1

carboxylesterase 1

chr12_+_7014126 1.454 ENST00000415834.1
ENST00000436789.1
LRRC23

leucine rich repeat containing 23

chr4_+_86525299 1.418 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr12_-_10282681 1.161 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr11_+_71900703 1.129 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr12_-_10282742 1.128 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A


C-type lectin domain family 7, member A


chr16_-_28634874 1.119 ENST00000395609.1
ENST00000350842.4
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr11_+_71900572 1.111 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr9_-_117111222 1.091 ENST00000374079.4
AKNA
AT-hook transcription factor
chr14_-_54423529 0.973 ENST00000245451.4
ENST00000559087.1
BMP4

bone morphogenetic protein 4

chr16_-_28608364 0.911 ENST00000533150.1
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr5_-_20575959 0.860 ENST00000507958.1
CDH18
cadherin 18, type 2
chr4_-_70518941 0.827 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1

UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 GO:0006068 ethanol catabolic process(GO:0006068)
0.2 3.9 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.7 2.2 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1 2.0 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.2 1.6 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.2 1.6 GO:0046485 ether lipid metabolic process(GO:0046485)
0.4 1.5 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.1 1.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.3 1.0 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.8 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.8 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.8 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.7 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.7 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.6 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.5 GO:0070986 left/right axis specification(GO:0070986)
0.1 0.4 GO:0071279 cellular response to cobalt ion(GO:0071279)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 1.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.7 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.6 GO:0043203 axon hillock(GO:0043203)
0.0 0.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.5 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.2 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.7 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 3.9 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.6 2.2 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 2.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 1.6 GO:0019770 IgG receptor activity(GO:0019770)
0.3 1.6 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.3 1.5 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1 1.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.0 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.8 GO:0070330 aromatase activity(GO:0070330)
0.0 0.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.7 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.7 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0005412 glucose:sodium symporter activity(GO:0005412)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 1.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.1 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 0.7 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors