Motif ID: AR_NR3C2
Z-value: 0.568
Transcription factors associated with AR_NR3C2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| AR | ENSG00000169083.11 | AR |
| NR3C2 | ENSG00000151623.10 | NR3C2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR3C2 | hg19_v2_chr4_-_149365827_149365870 | -0.54 | 5.9e-03 | Click! |
| AR | hg19_v2_chrX_+_66764375_66764465 | -0.15 | 4.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.2 | 2.0 | GO:0060744 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.2 | 1.2 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.2 | 1.1 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.2 | 1.0 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.1 | 0.3 | GO:0014876 | response to injury involved in regulation of muscle adaptation(GO:0014876) |
| 0.1 | 0.6 | GO:0010734 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.1 | 0.4 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.1 | 0.2 | GO:0042414 | epinephrine metabolic process(GO:0042414) epinephrine biosynthetic process(GO:0042418) |
| 0.1 | 0.3 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 0.0 | 0.3 | GO:0036018 | cellular response to erythropoietin(GO:0036018) |
| 0.0 | 0.3 | GO:0014718 | positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) |
| 0.0 | 0.1 | GO:0008050 | female courtship behavior(GO:0008050) |
| 0.0 | 0.4 | GO:0038171 | cannabinoid signaling pathway(GO:0038171) |
| 0.0 | 0.1 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.0 | 0.2 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.0 | 0.9 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.0 | 0.2 | GO:0010936 | negative regulation of macrophage cytokine production(GO:0010936) |
| 0.0 | 0.2 | GO:0050668 | cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668) |
| 0.0 | 0.2 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) |
| 0.0 | 0.2 | GO:0015746 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 0.0 | 0.1 | GO:0014707 | branchiomeric skeletal muscle development(GO:0014707) |
| 0.0 | 0.4 | GO:0051024 | positive regulation of immunoglobulin secretion(GO:0051024) |
| 0.0 | 0.3 | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) |
| 0.0 | 0.8 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.0 | 0.1 | GO:0090107 | regulation of high-density lipoprotein particle assembly(GO:0090107) |
| 0.0 | 2.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.1 | GO:0018283 | metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283) |
| 0.0 | 0.1 | GO:0034201 | response to oleic acid(GO:0034201) |
| 0.0 | 0.2 | GO:0048305 | immunoglobulin secretion(GO:0048305) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.6 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.1 | 1.0 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.8 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 0.6 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 2.0 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 0.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.1 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 1.4 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.1 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.1 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.3 | 1.0 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.1 | 0.3 | GO:0004019 | adenylosuccinate synthase activity(GO:0004019) |
| 0.1 | 1.2 | GO:0046870 | cadmium ion binding(GO:0046870) |
| 0.1 | 0.4 | GO:0004949 | cannabinoid receptor activity(GO:0004949) |
| 0.1 | 0.2 | GO:0004603 | phenylethanolamine N-methyltransferase activity(GO:0004603) |
| 0.1 | 0.4 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.1 | 0.4 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.0 | 0.1 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.0 | 0.2 | GO:0086089 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089) |
| 0.0 | 0.3 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.0 | 0.4 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.0 | 2.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.3 | GO:0035877 | death effector domain binding(GO:0035877) |
| 0.0 | 0.2 | GO:0015142 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.0 | 0.3 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.0 | 0.1 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.0 | 0.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 0.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 0.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.3 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 0.1 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.0 | 0.1 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.0 | 0.1 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.4 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.8 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.5 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 1.1 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.8 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.3 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 1.3 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
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