Motif ID: AR_NR3C2

Z-value: 0.568

Transcription factors associated with AR_NR3C2:

Gene SymbolEntrez IDGene Name
AR ENSG00000169083.11 AR
NR3C2 ENSG00000151623.10 NR3C2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR3C2hg19_v2_chr4_-_149365827_149365870-0.545.9e-03Click!
ARhg19_v2_chrX_+_66764375_66764465-0.154.9e-01Click!


Activity profile for motif AR_NR3C2.

activity profile for motif AR_NR3C2


Sorted Z-values histogram for motif AR_NR3C2

Sorted Z-values for motif AR_NR3C2



Network of associatons between targets according to the STRING database.



First level regulatory network of AR_NR3C2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 139 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_42916499 1.128 ENST00000601189.1
ENST00000599211.1
 LIPE

lipase, hormone-sensitive

chr4_+_75310851 1.020 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr2_+_102953608 0.970 ENST00000311734.2
ENST00000409584.1
 IL1RL1

interleukin 1 receptor-like 1

chr4_+_75311019 0.960 ENST00000502307.1
 AREG
amphiregulin
chr4_+_75480629 0.942 ENST00000380846.3
 AREGB
amphiregulin B
chr1_+_22979474 0.848 ENST00000509305.1
 C1QB
complement component 1, q subcomponent, B chain
chr12_+_53443680 0.835 ENST00000314250.6
ENST00000451358.1
 TENC1

tensin like C1 domain containing phosphatase (tensin 2)

chr12_+_53443963 0.824 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
 TENC1


tensin like C1 domain containing phosphatase (tensin 2)


chr1_+_22979676 0.714 ENST00000432749.2
ENST00000314933.6
 C1QB

complement component 1, q subcomponent, B chain

chr10_+_696000 0.710 ENST00000381489.5
 PRR26
proline rich 26
chr8_-_49833978 0.694 ENST00000020945.1
 SNAI2
snail family zinc finger 2
chr8_-_49834299 0.629 ENST00000396822.1
 SNAI2
snail family zinc finger 2
chr16_+_56642041 0.625 ENST00000245185.5
 MT2A
metallothionein 2A
chr18_+_56530136 0.587 ENST00000591083.1
 ZNF532
zinc finger protein 532
chr3_-_58563094 0.578 ENST00000464064.1
 FAM107A
family with sequence similarity 107, member A
chr16_+_56659687 0.565 ENST00000568293.1
ENST00000330439.6
 MT1E

metallothionein 1E

chr16_+_56642489 0.543 ENST00000561491.1
 MT2A
metallothionein 2A
chr2_-_231825668 0.445 ENST00000392039.2
 GPR55
G protein-coupled receptor 55
chr5_-_141392538 0.432 ENST00000503794.1
ENST00000510194.1
ENST00000504424.1
ENST00000513454.1
ENST00000458112.2
ENST00000542860.1
ENST00000503229.1
ENST00000500692.2
ENST00000311337.6
ENST00000504139.1
ENST00000505689.1
 GNPDA1










glucosamine-6-phosphate deaminase 1










chr11_+_18287721 0.411 ENST00000356524.4
 SAA1
serum amyloid A1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 2.0 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.4 1.3 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.2 1.2 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 1.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.2 1.0 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.9 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.8 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.1 0.6 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.4 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.4 GO:0038171 cannabinoid signaling pathway(GO:0038171)
0.0 0.4 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.1 0.3 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.1 0.3 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.3 GO:0036018 cellular response to erythropoietin(GO:0036018)
0.0 0.3 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.0 0.3 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 0.2 GO:0042414 epinephrine metabolic process(GO:0042414) epinephrine biosynthetic process(GO:0042418)
0.0 0.2 GO:0051697 protein delipidation(GO:0051697)
0.0 0.2 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.3 1.6 GO:0005602 complement component C1 complex(GO:0005602)
0.0 1.4 GO:0005901 caveola(GO:0005901)
0.1 1.0 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.8 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 1.2 GO:0046870 cadmium ion binding(GO:0046870)
0.4 1.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.3 1.0 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.8 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.4 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.1 0.4 GO:0045569 TRAIL binding(GO:0045569)
0.1 0.4 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.3 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.0 0.3 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.3 GO:0035877 death effector domain binding(GO:0035877)
0.0 0.3 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.3 GO:0031432 titin binding(GO:0031432)
0.1 0.2 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.0 0.2 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.2 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.3 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 1.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.8 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis