Motif ID: ATF2_ATF1_ATF3

Z-value: 0.948

Transcription factors associated with ATF2_ATF1_ATF3:

Gene SymbolEntrez IDGene Name
ATF1 ENSG00000123268.4 ATF1
ATF2 ENSG00000115966.12 ATF2
ATF3 ENSG00000162772.12 ATF3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ATF3hg19_v2_chr1_+_212738676_212738755-0.638.8e-04Click!
ATF1hg19_v2_chr12_+_51158263_511583950.291.7e-01Click!
ATF2hg19_v2_chr2_-_176032843_1760329410.272.1e-01Click!


Activity profile for motif ATF2_ATF1_ATF3.

activity profile for motif ATF2_ATF1_ATF3


Sorted Z-values histogram for motif ATF2_ATF1_ATF3

Sorted Z-values for motif ATF2_ATF1_ATF3



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2_ATF1_ATF3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_75311019 3.178 ENST00000502307.1
 AREG
amphiregulin
chr4_+_75310851 2.926 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr8_-_10697281 2.719 ENST00000553390.1
ENST00000524114.1
ENST00000554914.1
 SOX7
PINX1
SOX7
SRY (sex determining region Y)-box 7
PIN2/TERF1 interacting, telomerase inhibitor 1
Transcription factor SOX-7; Uncharacterized protein; cDNA FLJ58508, highly similar to Transcription factor SOX-7
chr14_+_68086515 2.711 ENST00000261783.3
 ARG2
arginase 2
chr4_+_75480629 2.577 ENST00000380846.3
 AREGB
amphiregulin B
chr2_-_216300784 2.551 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr6_+_126661253 2.312 ENST00000368326.1
ENST00000368325.1
ENST00000368328.4
 CENPW


centromere protein W


chr5_+_162887556 2.145 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
 HMMR


hyaluronan-mediated motility receptor (RHAMM)


chr7_+_5632436 2.073 ENST00000340250.6
ENST00000382361.3
 FSCN1

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

chr4_-_122744998 2.057 ENST00000274026.5
 CCNA2
cyclin A2
chr11_-_125366089 1.829 ENST00000366139.3
ENST00000278919.3
 FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr12_+_22778291 1.802 ENST00000545979.1
 ETNK1
ethanolamine kinase 1
chr19_-_51014345 1.770 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
 JOSD2


Josephin domain containing 2


chr11_+_13690249 1.752 ENST00000532701.1
 FAR1
fatty acyl CoA reductase 1
chr1_-_204121102 1.711 ENST00000367202.4
 ETNK2
ethanolamine kinase 2
chr4_-_104119528 1.708 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
 CENPE


centromere protein E, 312kDa


chr11_-_28129656 1.678 ENST00000263181.6
 KIF18A
kinesin family member 18A
chr1_-_204121298 1.647 ENST00000367199.2
 ETNK2
ethanolamine kinase 2
chr19_-_51014460 1.514 ENST00000595669.1
 JOSD2
Josephin domain containing 2
chr19_-_42927251 1.489 ENST00000597001.1
 LIPE
lipase, hormone-sensitive

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 468 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.8 6.1 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.3 5.1 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 4.2 GO:0016579 protein deubiquitination(GO:0016579)
0.1 3.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.6 3.2 GO:1904744 positive regulation of telomeric DNA binding(GO:1904744)
0.2 2.7 GO:0000050 urea cycle(GO:0000050)
0.9 2.6 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 2.6 GO:0018149 peptide cross-linking(GO:0018149)
0.2 2.3 GO:0051382 kinetochore assembly(GO:0051382)
0.1 2.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 2.2 GO:0031639 plasminogen activation(GO:0031639)
0.7 2.1 GO:0071314 cellular response to cocaine(GO:0071314)
0.4 2.1 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.4 2.1 GO:0030035 microspike assembly(GO:0030035)
0.7 2.0 GO:0070512 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.4 2.0 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.6 1.9 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.3 1.9 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.2 1.8 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.0 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 9.5 GO:0009986 cell surface(GO:0009986)
0.0 7.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 6.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.3 4.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.9 2.8 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.0 2.8 GO:0001533 cornified envelope(GO:0001533)
0.2 2.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 2.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.4 2.1 GO:0044393 microspike(GO:0044393)
0.5 2.0 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.2 2.0 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.1 2.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 2.0 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 1.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 1.7 GO:0031298 replication fork protection complex(GO:0031298)
0.1 1.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.5 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.5 1.4 GO:0005873 plus-end kinesin complex(GO:0005873)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 283 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.6 6.4 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.7 3.5 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 3.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 3.2 GO:0030674 protein binding, bridging(GO:0030674)
0.2 2.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 2.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.7 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.0 2.6 GO:0016504 peptidase activator activity(GO:0016504)
0.2 2.4 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 2.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 2.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 2.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.5 2.0 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.3 1.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 1.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.9 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.9 GO:0043022 ribosome binding(GO:0043022)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 6.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 4.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 3.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.4 PID_BARD1_PATHWAY BARD1 signaling events
0.1 3.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.0 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.7 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 1.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.3 PID_CDC42_PATHWAY CDC42 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.7 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 5.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 4.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 3.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 3.7 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 3.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.9 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 2.9 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 2.8 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.1 2.5 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.1 2.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 2.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.7 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production