Motif ID: ATF4

Z-value: 1.105


Transcription factors associated with ATF4:

Gene SymbolEntrez IDGene Name
ATF4 ENSG00000128272.10 ATF4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.682.5e-04Click!


Activity profile for motif ATF4.

activity profile for motif ATF4


Sorted Z-values histogram for motif ATF4

Sorted Z-values for motif ATF4



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4

PNG image of the network

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Top targets:


Showing 1 to 20 of 133 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_216300784 5.423 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr12_-_25102252 5.359 ENST00000261192.7
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_25101920 4.194 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr10_+_102106829 2.765 ENST00000370355.2
 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr21_-_44495919 2.715 ENST00000398158.1
 CBS
cystathionine-beta-synthase
chr21_-_44495964 2.440 ENST00000398168.1
ENST00000398165.3
 CBS

cystathionine-beta-synthase

chr15_+_41245160 2.422 ENST00000444189.2
ENST00000446533.3
 CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr6_+_151187074 2.084 ENST00000367308.4
 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr12_+_57624119 1.981 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
 SHMT2



serine hydroxymethyltransferase 2 (mitochondrial)



chr14_-_100841670 1.802 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
 WARS





tryptophanyl-tRNA synthetase





chr12_+_57624085 1.792 ENST00000553474.1
 SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr19_-_51014345 1.756 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
 JOSD2


Josephin domain containing 2


chr16_+_46918235 1.677 ENST00000340124.4
 GPT2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr11_+_62649158 1.667 ENST00000539891.1
ENST00000536981.1
 SLC3A2

solute carrier family 3 (amino acid transporter heavy chain), member 2

chr12_+_57623477 1.652 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
 SHMT2


serine hydroxymethyltransferase 2 (mitochondrial)


chr12_+_57623869 1.644 ENST00000414700.3
ENST00000557703.1
 SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

chr6_+_151187615 1.523 ENST00000441122.1
ENST00000423867.1
 MTHFD1L

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

chr3_-_48130707 1.498 ENST00000360240.6
ENST00000383737.4
 MAP4

microtubule-associated protein 4

chr14_+_24563510 1.486 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
 PCK2


phosphoenolpyruvate carboxykinase 2 (mitochondrial)


chr12_-_12674032 1.444 ENST00000298573.4
 DUSP16
dual specificity phosphatase 16

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 9.6 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
1.0 7.1 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
1.8 5.4 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.7 5.2 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.9 3.6 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.6 3.1 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.9 2.8 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 2.8 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.3 2.7 GO:0006116 NADH oxidation(GO:0006116)
0.4 2.6 GO:0051012 microtubule sliding(GO:0051012)
0.6 2.5 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.1 2.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.4 2.0 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.3 1.8 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.4 1.7 GO:0042853 L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.3 1.7 GO:0060356 leucine import(GO:0060356)
0.5 1.6 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.1 1.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.3 1.4 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 1.4 GO:0046325 negative regulation of glucose import(GO:0046325)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.9 7.1 GO:0070552 BRISC complex(GO:0070552)
0.4 5.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 3.1 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 2.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.0 GO:0015030 Cajal body(GO:0015030)
0.0 1.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 1.0 GO:0035976 AP1 complex(GO:0035976)
0.3 0.8 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.6 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.5 GO:0097452 GAIT complex(GO:0097452)
0.1 0.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 9.6 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
1.0 7.1 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 5.4 GO:0016504 peptidase activator activity(GO:0016504)
1.7 5.2 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.0 3.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.9 3.6 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.6 3.1 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 2.9 GO:0008483 transaminase activity(GO:0008483)
0.6 2.8 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 2.8 GO:0005179 hormone activity(GO:0005179)
0.9 2.7 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.6 2.5 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.8 2.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.7 2.0 GO:0008859 exoribonuclease II activity(GO:0008859)
0.3 1.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 1.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.5 1.6 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.1 1.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.4 GO:0043495 protein anchor(GO:0043495)
0.1 1.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 5.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.0 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.8 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.8 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 8.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 5.4 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2 5.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 5.2 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 3.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.0 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.9 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling