Motif ID: ATF5

Z-value: 0.740


Transcription factors associated with ATF5:

Gene SymbolEntrez IDGene Name
ATF5 ENSG00000169136.4 ATF5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ATF5hg19_v2_chr19_+_50431959_50431998-0.301.5e-01Click!


Activity profile for motif ATF5.

activity profile for motif ATF5


Sorted Z-values histogram for motif ATF5

Sorted Z-values for motif ATF5



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_41740181 2.274 ENST00000442711.1
 INHBA
inhibin, beta A
chr5_-_39219705 2.218 ENST00000351578.6
 FYB
FYN binding protein
chr1_-_17304771 1.986 ENST00000375534.3
 MFAP2
microfibrillar-associated protein 2
chr5_-_39219641 1.629 ENST00000509072.1
ENST00000504542.1
ENST00000505428.1
ENST00000506557.1
 FYB



FYN binding protein



chr2_-_113542063 1.507 ENST00000263339.3
 IL1A
interleukin 1, alpha
chr5_+_154393260 1.369 ENST00000435029.4
 KIF4B
kinesin family member 4B
chr5_+_156887027 1.354 ENST00000435489.2
ENST00000311946.7
 NIPAL4

NIPA-like domain containing 4

chr1_+_209859510 1.210 ENST00000367028.2
ENST00000261465.1
 HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr6_+_43738444 1.099 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
 VEGFA








vascular endothelial growth factor A








chr12_-_25101920 0.954 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr15_+_80733570 0.923 ENST00000533983.1
ENST00000527771.1
ENST00000525103.1
 ARNT2


aryl-hydrocarbon receptor nuclear translocator 2


chr2_-_26205340 0.883 ENST00000264712.3
 KIF3C
kinesin family member 3C
chr20_+_58179582 0.786 ENST00000371015.1
ENST00000395639.4
 PHACTR3

phosphatase and actin regulator 3

chr19_-_44285401 0.775 ENST00000262888.3
 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_+_16083154 0.770 ENST00000375771.1
 FBLIM1
filamin binding LIM protein 1
chr16_-_72127456 0.763 ENST00000562153.1
 TXNL4B
thioredoxin-like 4B
chr11_+_124735282 0.753 ENST00000397801.1
 ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr7_-_3083573 0.621 ENST00000396946.4
 CARD11
caspase recruitment domain family, member 11
chr6_-_88411911 0.591 ENST00000257787.5
 AKIRIN2
akirin 2
chr3_+_101504200 0.581 ENST00000422132.1
 NXPE3
neurexophilin and PC-esterase domain family, member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.8 2.3 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 2.0 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.3 1.5 GO:2000391 positive regulation of neutrophil extravasation(GO:2000391)
0.1 1.4 GO:0015693 magnesium ion transport(GO:0015693)
0.1 1.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 1.2 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 1.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 1.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.4 1.1 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.2 1.1 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.2 1.0 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.9 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.9 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.2 0.8 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
0.1 0.8 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.8 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 0.8 GO:0046541 saliva secretion(GO:0046541)
0.0 0.7 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.1 0.6 GO:0070970 interleukin-2 secretion(GO:0070970)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.3 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 2.3 GO:0005871 kinesin complex(GO:0005871)
0.1 2.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.4 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.2 GO:0005682 U5 snRNP(GO:0005682)
0.0 1.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.5 GO:0051286 cell tip(GO:0051286)
0.0 0.5 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.5 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 0.4 GO:0044609 DBIRD complex(GO:0044609)
0.0 0.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 0.2 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.1 0.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.2 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.1 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 1.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.4 1.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 1.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 1.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 1.1 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 1.0 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 1.0 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.9 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.9 GO:0003777 microtubule motor activity(GO:0003777)
0.2 0.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.8 GO:0031005 filamin binding(GO:0031005)
0.0 0.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.6 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 2.3 PID_ALK1_PATHWAY ALK1 signaling events
0.0 2.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.5 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 1.1 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 0.8 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.3 PID_VEGFR1_PATHWAY VEGFR1 specific signals

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 2.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.3 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 1.2 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.1 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.0 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.6 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.6 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 0.4 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.3 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine