Motif ID: ATF6

Z-value: 0.616


Transcription factors associated with ATF6:

Gene SymbolEntrez IDGene Name
ATF6 ENSG00000118217.5 ATF6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ATF6hg19_v2_chr1_+_161736072_161736093-0.193.8e-01Click!


Activity profile for motif ATF6.

activity profile for motif ATF6


Sorted Z-values histogram for motif ATF6

Sorted Z-values for motif ATF6



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_35630926 0.792 ENST00000588081.1
ENST00000589121.1
 FXYD1

FXYD domain containing ion transport regulator 1

chr19_+_35630628 0.779 ENST00000588715.1
ENST00000588607.1
 FXYD1

FXYD domain containing ion transport regulator 1

chrX_-_100914781 0.598 ENST00000431597.1
ENST00000458024.1
ENST00000413506.1
ENST00000440675.1
ENST00000328766.5
ENST00000356824.4
 ARMCX2





armadillo repeat containing, X-linked 2





chr10_-_118032979 0.550 ENST00000355422.6
 GFRA1
GDNF family receptor alpha 1
chr12_+_56661033 0.512 ENST00000433805.2
 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr12_+_56660633 0.468 ENST00000308197.5
 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr7_-_19157248 0.464 ENST00000242261.5
 TWIST1
twist family bHLH transcription factor 1
chr3_+_129158926 0.420 ENST00000347300.2
ENST00000296266.3
 IFT122

intraflagellar transport 122 homolog (Chlamydomonas)

chrX_-_101397433 0.408 ENST00000372774.3
 TCEAL6
transcription elongation factor A (SII)-like 6
chr3_+_129159039 0.405 ENST00000507564.1
ENST00000431818.2
ENST00000504021.1
ENST00000349441.2
ENST00000348417.2
ENST00000440957.2
 IFT122





intraflagellar transport 122 homolog (Chlamydomonas)





chr14_+_65016620 0.404 ENST00000298705.1
 PPP1R36
protein phosphatase 1, regulatory subunit 36
chr15_+_72947079 0.400 ENST00000421285.3
 GOLGA6B
golgin A6 family, member B
chr7_+_102073966 0.339 ENST00000495936.1
ENST00000356387.2
ENST00000478730.2
ENST00000468241.1
ENST00000403646.3
 ORAI2




ORAI calcium release-activated calcium modulator 2




chr16_-_66959429 0.332 ENST00000420652.1
ENST00000299759.6
 RRAD

Ras-related associated with diabetes

chr9_+_100000717 0.320 ENST00000375205.2
ENST00000357054.1
ENST00000395220.1
ENST00000375202.2
ENST00000411667.2
 CCDC180




coiled-coil domain containing 180




chr3_+_184053703 0.319 ENST00000450976.1
ENST00000418281.1
ENST00000340957.5
ENST00000433578.1
 FAM131A



family with sequence similarity 131, member A



chr10_+_22634384 0.300 ENST00000376624.3
ENST00000376603.2
ENST00000376601.1
ENST00000538630.1
ENST00000456231.2
ENST00000313311.6
ENST00000435326.1
 SPAG6






sperm associated antigen 6






chr3_+_100211412 0.294 ENST00000323523.4
ENST00000403410.1
ENST00000449609.1
 TMEM45A


transmembrane protein 45A


chr7_-_98467629 0.290 ENST00000339375.4
 TMEM130
transmembrane protein 130
chr9_-_79520989 0.286 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
 PRUNE2


prune homolog 2 (Drosophila)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.6 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.0 1.0 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2 0.8 GO:0060830 intraciliary anterograde transport(GO:0035720) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.2 0.5 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.0 0.5 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 0.3 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.3 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.3 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 0.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 0.2 GO:1902310 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.2 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.1 0.2 GO:0061054 dermatome development(GO:0061054) regulation of dermatome development(GO:0061183)
0.1 0.2 GO:0007343 egg activation(GO:0007343)
0.0 0.2 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.2 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.0 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.2 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.8 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.3 GO:0030849 autosome(GO:0030849)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.2 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.1 0.2 GO:0043293 apoptosome(GO:0043293)
0.1 0.2 GO:0033011 perinuclear theca(GO:0033011)
0.0 0.2 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.1 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.0 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.0 GO:0048039 ubiquinone binding(GO:0048039)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.0 0.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.5 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.3 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.2 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.2 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.2 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.1 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.2 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.1 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE