Motif ID: AUGGCUU

Z-value: 0.331


Mature miRNA associated with seed AUGGCUU:

NamemiRBase Accession
hsa-miR-135a-5p MIMAT0000428
hsa-miR-135b-5p MIMAT0000758



Activity profile for motif AUGGCUU.

activity profile for motif AUGGCUU


Sorted Z-values histogram for motif AUGGCUU

Sorted Z-values for motif AUGGCUU



Network of associatons between targets according to the STRING database.



First level regulatory network of AUGGCUU

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_15016725 0.639 ENST00000336079.3
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr15_-_68498376 0.422 ENST00000540479.1
ENST00000395465.3
CALML4

calmodulin-like 4

chr11_-_115375107 0.383 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1





cell adhesion molecule 1





chr8_-_72268889 0.306 ENST00000388742.4
EYA1
eyes absent homolog 1 (Drosophila)
chr6_+_151815143 0.301 ENST00000239374.7
ENST00000367290.5
CCDC170

coiled-coil domain containing 170

chr5_+_76506706 0.296 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
PDE8B




phosphodiesterase 8B




chr2_-_213403565 0.290 ENST00000342788.4
ENST00000436443.1
ERBB4

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

chr5_+_42423872 0.278 ENST00000230882.4
ENST00000357703.3
GHR

growth hormone receptor

chr1_-_68962782 0.270 ENST00000456315.2
DEPDC1
DEP domain containing 1
chrX_-_135849484 0.264 ENST00000370620.1
ENST00000535227.1
ARHGEF6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr4_-_149365827 0.253 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr3_+_179370517 0.249 ENST00000263966.3
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr19_+_13906250 0.248 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr17_-_7832753 0.239 ENST00000303790.2
KCNAB3
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr3_+_3841108 0.218 ENST00000319331.3
LRRN1
leucine rich repeat neuronal 1
chr1_-_76076793 0.215 ENST00000370859.3
SLC44A5
solute carrier family 44, member 5
chr14_+_56585048 0.214 ENST00000267460.4
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr1_+_65210772 0.210 ENST00000371072.4
ENST00000294428.3
RAVER2

ribonucleoprotein, PTB-binding 2

chr1_-_150208291 0.208 ENST00000533654.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr13_+_31774073 0.199 ENST00000343307.4
B3GALTL
beta 1,3-galactosyltransferase-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.4 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.3 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.1 0.3 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.1 0.3 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 0.3 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.2 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:1901908 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.1 GO:0015883 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350)
0.0 0.1 GO:0097069 cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.0 0.1 GO:1905246 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.0 0.1 GO:0048372 lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378)
0.0 0.1 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.0 0.1 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.1 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.1 GO:0032240 negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.1 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.3 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.2 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.1 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 0.1 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.0 0.1 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.0 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.0 0.0 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.2 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.2 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.0 0.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.2 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.1 GO:0098808 mRNA cap binding(GO:0098808)
0.0 0.1 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0 0.1 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.0 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling