Motif ID: AUUGCAC

Z-value: 0.742


Mature miRNA associated with seed AUUGCAC:

NamemiRBase Accession
hsa-miR-25-3p MIMAT0000081
hsa-miR-32-5p MIMAT0000090
hsa-miR-363-3p MIMAT0000707
hsa-miR-367-3p MIMAT0000719
hsa-miR-92a-3p MIMAT0000092
hsa-miR-92b-3p MIMAT0003218



Activity profile for motif AUUGCAC.

activity profile for motif AUUGCAC


Sorted Z-values histogram for motif AUUGCAC

Sorted Z-values for motif AUUGCAC



Network of associatons between targets according to the STRING database.



First level regulatory network of AUUGCAC

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_111119804 1.335 ENST00000394607.3
ENST00000302274.3
 ELOVL6

ELOVL fatty acid elongase 6

chr12_-_54813229 1.263 ENST00000293379.4
 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr4_-_139163491 1.219 ENST00000280612.5
 SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr21_-_44846999 1.198 ENST00000270162.6
 SIK1
salt-inducible kinase 1
chr2_+_23608064 1.166 ENST00000486442.1
 KLHL29
kelch-like family member 29
chr12_-_95044309 1.034 ENST00000261226.4
 TMCC3
transmembrane and coiled-coil domain family 3
chr2_+_48541776 0.997 ENST00000413569.1
ENST00000340553.3
 FOXN2

forkhead box N2

chr20_-_56284816 0.993 ENST00000395819.3
ENST00000341744.3
 PMEPA1

prostate transmembrane protein, androgen induced 1

chr12_+_66217911 0.954 ENST00000403681.2
 HMGA2
high mobility group AT-hook 2
chr5_-_157002775 0.919 ENST00000257527.4
 ADAM19
ADAM metallopeptidase domain 19
chr9_+_116207007 0.903 ENST00000374140.2
 RGS3
regulator of G-protein signaling 3
chr3_+_47324424 0.855 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
 KLHL18


kelch-like family member 18


chr19_+_41725088 0.843 ENST00000301178.4
 AXL
AXL receptor tyrosine kinase
chr5_-_127873659 0.836 ENST00000262464.4
 FBN2
fibrillin 2
chr22_-_37823468 0.690 ENST00000402918.2
 ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr10_+_120967072 0.667 ENST00000392870.2
 GRK5
G protein-coupled receptor kinase 5
chr9_-_110251836 0.656 ENST00000374672.4
 KLF4
Kruppel-like factor 4 (gut)
chr5_-_77844974 0.642 ENST00000515007.2
 LHFPL2
lipoma HMGIC fusion partner-like 2
chr19_-_45663408 0.636 ENST00000317951.4
 NKPD1
NTPase, KAP family P-loop domain containing 1
chr11_+_65082289 0.614 ENST00000279249.2
 CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 1.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 1.3 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.2 1.2 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 1.2 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.2 1.0 GO:0031052 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.0 0.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.8 GO:2000669 positive regulation of pinocytosis(GO:0048549) negative regulation of dendritic cell apoptotic process(GO:2000669)
0.1 0.8 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 0.7 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.1 0.7 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.7 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 0.6 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.1 0.6 GO:0031585 regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585) secretory granule localization(GO:0032252) endoplasmic reticulum localization(GO:0051643)
0.1 0.6 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.6 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.2 0.5 GO:1902534 single-organism membrane invagination(GO:1902534)
0.2 0.5 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 0.5 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.1 0.5 GO:0003241 growth involved in heart morphogenesis(GO:0003241)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.3 1.3 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 1.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.9 GO:0033643 host cell part(GO:0033643)
0.0 0.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.7 GO:0005883 neurofilament(GO:0005883)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.6 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.1 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.6 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.5 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.4 GO:0090533 cation-transporting ATPase complex(GO:0090533)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 1.6 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 1.3 GO:0000146 microfilament motor activity(GO:0000146)
0.0 1.3 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.2 1.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 1.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 1.0 GO:0035501 MH1 domain binding(GO:0035501)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.1 0.9 GO:0048185 activin binding(GO:0048185)
0.1 0.8 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 0.8 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 0.7 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.1 0.7 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.7 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.7 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.6 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.6 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.2 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.2 PID_S1P_S1P1_PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.6 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.0 1.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.2 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.9 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.5 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE
0.0 0.4 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.4 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters