Motif ID: BACH2
Z-value: 0.571
Transcription factors associated with BACH2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| BACH2 | ENSG00000112182.10 | BACH2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BACH2 | hg19_v2_chr6_-_91006461_91006517, hg19_v2_chr6_-_91006627_91006641 | -0.53 | 7.5e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.5 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.4 | 1.3 | GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
| 0.3 | 1.4 | GO:0033123 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
| 0.3 | 1.2 | GO:0021812 | neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) |
| 0.3 | 1.1 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.3 | 1.7 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.3 | 0.5 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.3 | 2.2 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.2 | 6.3 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.2 | 1.2 | GO:0031959 | mineralocorticoid receptor signaling pathway(GO:0031959) |
| 0.2 | 1.1 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.2 | 1.9 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.2 | 0.3 | GO:1903524 | positive regulation of vasoconstriction(GO:0045907) positive regulation of blood circulation(GO:1903524) |
| 0.2 | 3.0 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.2 | 4.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 0.5 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.1 | 0.7 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.1 | 2.7 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 0.5 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
| 0.1 | 0.3 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.1 | 0.5 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.1 | 0.4 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.1 | 0.2 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.1 | 0.2 | GO:0046167 | glycerol-3-phosphate biosynthetic process(GO:0046167) |
| 0.1 | 1.2 | GO:0044351 | macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385) |
| 0.1 | 0.9 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.1 | 0.8 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.1 | 4.9 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 0.6 | GO:0001866 | NK T cell proliferation(GO:0001866) |
| 0.1 | 0.4 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.0 | 2.4 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.0 | 0.3 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 0.0 | 0.2 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.0 | 0.4 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.0 | 0.3 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.0 | 0.4 | GO:0015014 | protein sulfation(GO:0006477) heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 0.6 | GO:0016102 | retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102) |
| 0.0 | 0.3 | GO:0050428 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.0 | 0.1 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 0.0 | 0.5 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.2 | GO:2000546 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
| 0.0 | 0.3 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 0.2 | GO:0032962 | regulation of inositol trisphosphate biosynthetic process(GO:0032960) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.0 | 0.5 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 0.0 | 0.3 | GO:0030091 | protein repair(GO:0030091) |
| 0.0 | 0.6 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 0.2 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.0 | 0.1 | GO:1901656 | glycoside transport(GO:1901656) |
| 0.0 | 0.2 | GO:1903401 | L-lysine transmembrane transport(GO:1903401) |
| 0.0 | 0.2 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 0.0 | 1.3 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.0 | 0.2 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.0 | 1.9 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 0.0 | 0.1 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.0 | 0.3 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.0 | 0.5 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 0.2 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.0 | 0.1 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.0 | 0.3 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 1.8 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 0.1 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
| 0.0 | 0.2 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.0 | 0.0 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 0.0 | 0.0 | GO:1903422 | negative regulation of synaptic vesicle recycling(GO:1903422) |
| 0.0 | 0.1 | GO:0009438 | methylglyoxal metabolic process(GO:0009438) |
| 0.0 | 1.0 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 1.1 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 0.0 | GO:2001045 | negative regulation of neuroblast proliferation(GO:0007406) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.0 | 0.1 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.4 | 1.2 | GO:0005607 | laminin-2 complex(GO:0005607) laminin-10 complex(GO:0043259) |
| 0.4 | 6.3 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.3 | 1.4 | GO:0030934 | anchoring collagen complex(GO:0030934) |
| 0.3 | 2.1 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.5 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 3.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 0.4 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.0 | 0.1 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 0.0 | 0.5 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 2.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.4 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 1.6 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.4 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 0.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 0.2 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 0.4 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 2.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 0.4 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.1 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.0 | 0.1 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.0 | 2.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.4 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.9 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.0 | 0.1 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.0 | 1.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.2 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.0 | 3.7 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 2.2 | GO:0001726 | ruffle(GO:0001726) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 6.3 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.7 | 2.0 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.4 | 1.1 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.3 | 2.1 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.3 | 2.7 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.2 | 0.5 | GO:0019981 | interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981) |
| 0.1 | 1.1 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.1 | 1.4 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.8 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 0.4 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.1 | 0.3 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.1 | 3.5 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.1 | 0.2 | GO:0004370 | glycerol kinase activity(GO:0004370) |
| 0.1 | 1.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.3 | GO:0004473 | malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.1 | 0.3 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.1 | 0.2 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.0 | 1.3 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 1.2 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.5 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.0 | 0.1 | GO:0017082 | mineralocorticoid receptor activity(GO:0017082) |
| 0.0 | 0.2 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.0 | 4.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.3 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 2.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.5 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.0 | 0.3 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.0 | 0.3 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 0.2 | GO:0015189 | L-lysine transmembrane transporter activity(GO:0015189) |
| 0.0 | 0.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.2 | GO:0047035 | testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.0 | 2.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.3 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 0.2 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.0 | 1.0 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.4 | GO:0016918 | retinal binding(GO:0016918) |
| 0.0 | 0.3 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 1.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.1 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.8 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 6.9 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 1.1 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.5 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.0 | 1.4 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 2.2 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.8 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.4 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.4 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.2 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 5.2 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.5 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 5.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.8 | PID_AURORA_B_PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 2.7 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.1 | 1.5 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 2.4 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 4.3 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.4 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.5 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 1.7 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 1.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.2 | REACTOME_SIGNALING_BY_FGFR3_MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 0.5 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.5 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.4 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.3 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.2 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
