Motif ID: BACH2

Z-value: 0.571


Transcription factors associated with BACH2:

Gene SymbolEntrez IDGene Name
BACH2 ENSG00000112182.10 BACH2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BACH2hg19_v2_chr6_-_91006461_91006517,
hg19_v2_chr6_-_91006627_91006641
-0.537.5e-03Click!


Activity profile for motif BACH2.

activity profile for motif BACH2


Sorted Z-values histogram for motif BACH2

Sorted Z-values for motif BACH2



Network of associatons between targets according to the STRING database.



First level regulatory network of BACH2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_150480551 3.186 ENST00000369049.4
ENST00000369047.4
ECM1

extracellular matrix protein 1

chr1_+_150480576 3.152 ENST00000346569.6
ECM1
extracellular matrix protein 1
chr18_+_21452964 2.461 ENST00000587184.1
LAMA3
laminin, alpha 3
chr11_-_102668879 2.310 ENST00000315274.6
MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr18_+_21452804 2.118 ENST00000269217.6
LAMA3
laminin, alpha 3
chr2_+_113875466 1.969 ENST00000361779.3
ENST00000259206.5
ENST00000354115.2
IL1RN


interleukin 1 receptor antagonist


chr19_-_36019123 1.844 ENST00000588674.1
ENST00000452271.2
ENST00000518157.1
SBSN


suprabasin


chr17_-_39769005 1.816 ENST00000301653.4
ENST00000593067.1
KRT16

keratin 16

chr6_+_74405804 1.754 ENST00000287097.5
CD109
CD109 molecule
chr1_-_153521597 1.750 ENST00000368712.1
S100A3
S100 calcium binding protein A3
chr6_+_74405501 1.732 ENST00000437994.2
ENST00000422508.2
CD109

CD109 molecule

chr11_-_6341724 1.396 ENST00000530979.1
PRKCDBP
protein kinase C, delta binding protein
chr3_-_48632593 1.382 ENST00000454817.1
ENST00000328333.8
COL7A1

collagen, type VII, alpha 1

chr1_-_153521714 1.369 ENST00000368713.3
S100A3
S100 calcium binding protein A3
chr17_+_4853442 1.320 ENST00000522301.1
ENO3
enolase 3 (beta, muscle)
chr11_-_62323702 1.318 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr1_+_152881014 1.284 ENST00000368764.3
ENST00000392667.2
IVL

involucrin

chr20_+_44637526 1.230 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr7_-_107643674 1.228 ENST00000222399.6
LAMB1
laminin, beta 1
chr11_-_102826434 1.192 ENST00000340273.4
ENST00000260302.3
MMP13

matrix metallopeptidase 13 (collagenase 3)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.3 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 4.9 GO:0030574 collagen catabolic process(GO:0030574)
0.2 4.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.6 3.5 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.2 3.0 GO:0051546 keratinocyte migration(GO:0051546)
0.1 2.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 2.4 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 2.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 1.9 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 1.9 GO:0030834 regulation of actin filament depolymerization(GO:0030834)
0.0 1.8 GO:0070268 cornification(GO:0070268)
0.3 1.7 GO:0007296 vitellogenesis(GO:0007296)
0.3 1.4 GO:0033123 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.4 1.3 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.0 1.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.3 1.2 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.2 1.2 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959)
0.1 1.2 GO:0044351 macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385)
0.3 1.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.2 1.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.6 4.6 GO:0005610 laminin-5 complex(GO:0005610)
0.0 3.7 GO:0030027 lamellipodium(GO:0030027)
0.1 3.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 2.7 GO:0005882 intermediate filament(GO:0005882)
0.0 2.2 GO:0001726 ruffle(GO:0001726)
0.3 2.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 2.1 GO:0001533 cornified envelope(GO:0001533)
0.0 2.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.6 GO:0043034 costamere(GO:0043034)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.3 1.4 GO:0030934 anchoring collagen complex(GO:0030934)
0.4 1.2 GO:0005607 laminin-2 complex(GO:0005607) laminin-10 complex(GO:0043259)
0.0 0.9 GO:0031904 endosome lumen(GO:0031904)
0.1 0.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.4 GO:0032437 cuticular plate(GO:0032437)
0.0 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.4 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 6.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 2.7 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 2.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 2.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.7 2.0 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 1.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 1.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 1.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.4 1.1 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 1.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.0 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 0.8 GO:1990254 keratin filament binding(GO:1990254)
0.2 0.5 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3 5.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 5.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 5.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.8 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.4 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.2 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.1 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.5 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 4.3 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 2.7 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 2.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.7 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.5 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.2 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade