Motif ID: BARHL1

Z-value: 2.570


Transcription factors associated with BARHL1:

Gene SymbolEntrez IDGene Name
BARHL1 ENSG00000125492.5 BARHL1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BARHL1hg19_v2_chr9_+_135457530_135457572-0.528.8e-03Click!


Activity profile for motif BARHL1.

activity profile for motif BARHL1


Sorted Z-values histogram for motif BARHL1

Sorted Z-values for motif BARHL1



Network of associatons between targets according to the STRING database.



First level regulatory network of BARHL1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_19988462 15.954 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr12_-_71551868 15.034 ENST00000247829.3
 TSPAN8
tetraspanin 8
chr12_-_71551652 14.805 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr2_+_228735763 12.710 ENST00000373666.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr2_+_228736321 11.791 ENST00000309931.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr3_-_197686847 10.433 ENST00000265239.6
 IQCG
IQ motif containing G
chr5_+_121465207 9.985 ENST00000296600.4
 ZNF474
zinc finger protein 474
chr15_-_56757329 9.796 ENST00000260453.3
 MNS1
meiosis-specific nuclear structural 1
chr12_+_7013897 8.699 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr9_-_138391692 8.691 ENST00000429260.2
 C9orf116
chromosome 9 open reading frame 116
chr6_+_151815143 8.621 ENST00000239374.7
ENST00000367290.5
 CCDC170

coiled-coil domain containing 170

chr1_+_12806141 8.544 ENST00000288048.5
 C1orf158
chromosome 1 open reading frame 158
chr17_+_45908974 8.158 ENST00000269025.4
 LRRC46
leucine rich repeat containing 46
chr12_-_25348007 8.123 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1






cancer susceptibility candidate 1






chr15_+_71228826 8.118 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
 LRRC49




leucine rich repeat containing 49




chr11_+_60467047 8.059 ENST00000300226.2
 MS4A8
membrane-spanning 4-domains, subfamily A, member 8
chr13_+_43355732 7.898 ENST00000313851.1
 FAM216B
family with sequence similarity 216, member B
chr14_+_96949319 7.762 ENST00000554706.1
 AK7
adenylate kinase 7
chr4_-_147867025 7.742 ENST00000502319.1
ENST00000325106.4
ENST00000504425.1
 TTC29


tetratricopeptide repeat domain 29


chr12_+_111051832 7.633 ENST00000550703.2
ENST00000551590.1
 TCTN1

tectonic family member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 615 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 32.5 GO:0007368 determination of left/right symmetry(GO:0007368)
1.1 23.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.3 21.3 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.9 17.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
2.4 17.0 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
1.6 15.6 GO:0007288 sperm axoneme assembly(GO:0007288)
0.7 13.9 GO:0070986 left/right axis specification(GO:0070986)
0.1 13.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.1 12.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 10.1 GO:0016266 O-glycan processing(GO:0016266)
2.5 10.0 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 9.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 9.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
3.0 8.9 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 8.6 GO:0060271 cilium morphogenesis(GO:0060271)
0.5 8.0 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.2 8.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.1 7.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 7.9 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.4 7.8 GO:0015671 oxygen transport(GO:0015671)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 31.5 GO:0036038 MKS complex(GO:0036038)
0.2 25.2 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 23.7 GO:0005887 integral component of plasma membrane(GO:0005887)
1.1 22.5 GO:0042613 MHC class II protein complex(GO:0042613)
2.2 15.6 GO:0002177 manchette(GO:0002177)
1.2 12.8 GO:0036157 outer dynein arm(GO:0036157)
0.0 11.8 GO:0005929 cilium(GO:0005929)
0.2 11.3 GO:0009925 basal plasma membrane(GO:0009925)
0.6 9.4 GO:0005833 hemoglobin complex(GO:0005833)
0.1 8.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 8.9 GO:0001650 fibrillar center(GO:0001650)
0.0 8.5 GO:0070382 exocytic vesicle(GO:0070382)
0.0 8.5 GO:0019867 outer membrane(GO:0019867)
0.1 7.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 7.6 GO:0005844 polysome(GO:0005844)
0.1 7.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 7.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.5 6.4 GO:0097433 dense body(GO:0097433)
0.2 5.7 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 5.0 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 381 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 30.9 GO:0005178 integrin binding(GO:0005178)
0.0 27.0 GO:0005509 calcium ion binding(GO:0005509)
1.2 24.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.3 16.0 GO:0030544 Hsp70 protein binding(GO:0030544)
3.3 13.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.8 11.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 11.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 11.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.5 10.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.5 9.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.7 9.2 GO:0070330 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) aromatase activity(GO:0070330)
0.4 8.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 8.8 GO:0017160 Ral GTPase binding(GO:0017160)
1.7 8.6 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.1 8.2 GO:0019843 rRNA binding(GO:0019843)
1.9 7.8 GO:0016160 amylase activity(GO:0016160)
1.1 7.8 GO:0004127 cytidylate kinase activity(GO:0004127)
0.4 7.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 6.9 GO:0019894 kinesin binding(GO:0019894)
1.3 6.6 GO:0035529 NADH pyrophosphatase activity(GO:0035529)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 8.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 5.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 3.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 2.9 PID_INSULIN_PATHWAY Insulin Pathway
0.0 2.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 2.4 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 2.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.8 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.5 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.2 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 20.9 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 16.4 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.6 14.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
1.0 13.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.8 13.6 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
1.4 12.4 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 11.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 8.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 5.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 5.1 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 4.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 4.3 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 3.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 3.5 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 2.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 2.5 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 2.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.4 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 2.3 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 2.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1