Motif ID: BARHL2

Z-value: 1.409


Transcription factors associated with BARHL2:

Gene SymbolEntrez IDGene Name
BARHL2 ENSG00000143032.7 BARHL2



Activity profile for motif BARHL2.

activity profile for motif BARHL2


Sorted Z-values histogram for motif BARHL2

Sorted Z-values for motif BARHL2



Network of associatons between targets according to the STRING database.



First level regulatory network of BARHL2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_208031943 5.304 ENST00000421199.1
ENST00000457962.1
 KLF7

Kruppel-like factor 7 (ubiquitous)

chr5_+_31193847 4.978 ENST00000514738.1
ENST00000265071.2
 CDH6

cadherin 6, type 2, K-cadherin (fetal kidney)

chr4_+_69313145 4.852 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr18_+_29027696 4.761 ENST00000257189.4
 DSG3
desmoglein 3
chr6_+_151646800 4.464 ENST00000354675.6
 AKAP12
A kinase (PRKA) anchor protein 12
chr12_-_89746173 4.117 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr12_+_107712173 3.931 ENST00000280758.5
ENST00000420571.2
 BTBD11

BTB (POZ) domain containing 11

chr18_+_21529811 3.908 ENST00000588004.1
 LAMA3
laminin, alpha 3
chr17_-_38859996 3.879 ENST00000264651.2
 KRT24
keratin 24
chr16_-_46655538 3.823 ENST00000303383.3
 SHCBP1
SHC SH2-domain binding protein 1
chr12_-_25055177 3.611 ENST00000538118.1
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr2_-_238322800 3.603 ENST00000392004.3
ENST00000433762.1
ENST00000347401.3
ENST00000353578.4
ENST00000346358.4
ENST00000392003.2
 COL6A3





collagen, type VI, alpha 3





chr17_+_70117153 3.425 ENST00000245479.2
 SOX9
SRY (sex determining region Y)-box 9
chr5_-_146781153 3.422 ENST00000520473.1
 DPYSL3
dihydropyrimidinase-like 3
chr19_-_43382142 3.327 ENST00000597058.1
 PSG1
pregnancy specific beta-1-glycoprotein 1
chrX_+_135251783 3.165 ENST00000394153.2
 FHL1
four and a half LIM domains 1
chrX_+_135252050 3.154 ENST00000449474.1
ENST00000345434.3
 FHL1

four and a half LIM domains 1

chr2_-_238323007 3.150 ENST00000295550.4
 COL6A3
collagen, type VI, alpha 3
chr16_+_50300427 3.082 ENST00000394697.2
ENST00000566433.2
ENST00000538642.1
 ADCY7


adenylate cyclase 7


chr2_+_158114051 3.024 ENST00000259056.4
 GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 302 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.4 GO:0070268 cornification(GO:0070268)
0.3 8.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 8.0 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 7.3 GO:0030574 collagen catabolic process(GO:0030574)
0.1 4.8 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 4.6 GO:0007565 female pregnancy(GO:0007565)
0.3 4.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 4.3 GO:0031424 keratinization(GO:0031424)
1.4 4.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 4.1 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.2 4.0 GO:0034199 activation of protein kinase A activity(GO:0034199)
1.3 3.9 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.2 3.9 GO:0051639 actin filament network formation(GO:0051639)
0.5 3.7 GO:0051136 regulation of NK T cell differentiation(GO:0051136)
0.0 3.7 GO:0007219 Notch signaling pathway(GO:0007219)
0.6 3.6 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 3.5 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
1.1 3.4 GO:0060516 primary prostatic bud elongation(GO:0060516) renal vesicle induction(GO:0072034)
0.3 3.4 GO:0051764 actin crosslink formation(GO:0051764)
0.2 3.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.4 GO:0005925 focal adhesion(GO:0005925)
0.1 11.9 GO:0005882 intermediate filament(GO:0005882)
1.0 8.1 GO:0005610 laminin-5 complex(GO:0005610)
0.6 8.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 4.8 GO:0030057 desmosome(GO:0030057)
0.0 4.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 4.2 GO:0030027 lamellipodium(GO:0030027)
0.1 3.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 3.7 GO:0071437 invadopodium(GO:0071437)
0.1 3.5 GO:0097228 sperm principal piece(GO:0097228)
0.1 3.4 GO:0035371 microtubule plus-end(GO:0035371)
0.1 3.4 GO:0031941 filamentous actin(GO:0031941)
0.0 3.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 3.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.8 3.1 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 3.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 2.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 2.9 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 2.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.9 GO:0035579 specific granule membrane(GO:0035579)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 203 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 7.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 7.8 GO:0005198 structural molecule activity(GO:0005198)
0.0 6.6 GO:0008236 serine-type peptidase activity(GO:0008236)
0.3 4.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 4.6 GO:0045296 cadherin binding(GO:0045296)
0.0 4.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 4.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 4.2 GO:0003924 GTPase activity(GO:0003924)
0.0 4.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 4.1 GO:0005179 hormone activity(GO:0005179)
0.2 3.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.6 3.8 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 3.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.6 3.6 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.3 3.4 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 3.4 GO:0031005 filamin binding(GO:0031005)
0.8 3.1 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 3.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 3.1 GO:0042169 SH2 domain binding(GO:0042169)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.4 8.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 6.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 5.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 4.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 4.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 3.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 3.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.5 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 2.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 2.2 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 1.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 9.3 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.3 4.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 4.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.5 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 4.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 4.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 4.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 4.0 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 3.9 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 3.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 3.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 3.2 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 3.2 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 3.1 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.3 2.9 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.9 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 2.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway