Motif ID: BBX

Z-value: 0.511


Transcription factors associated with BBX:

Gene SymbolEntrez IDGene Name
BBX ENSG00000114439.14 BBX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BBXhg19_v2_chr3_+_107241783_1072418500.414.9e-02Click!


Activity profile for motif BBX.

activity profile for motif BBX


Sorted Z-values histogram for motif BBX

Sorted Z-values for motif BBX



Network of associatons between targets according to the STRING database.



First level regulatory network of BBX

PNG image of the network

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Top targets:


Showing 1 to 20 of 98 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_228735763 2.188 ENST00000373666.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr7_-_16921601 1.951 ENST00000402239.3
ENST00000310398.2
ENST00000414935.1
 AGR3


anterior gradient 3


chr20_-_7921090 1.892 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr11_+_60467047 1.271 ENST00000300226.2
 MS4A8
membrane-spanning 4-domains, subfamily A, member 8
chr1_-_161337662 1.181 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr1_-_216978709 0.586 ENST00000360012.3
 ESRRG
estrogen-related receptor gamma
chr4_-_123542224 0.545 ENST00000264497.3
 IL21
interleukin 21
chr2_-_62081148 0.533 ENST00000404929.1
 FAM161A
family with sequence similarity 161, member A
chr2_-_62081254 0.529 ENST00000405894.3
 FAM161A
family with sequence similarity 161, member A
chr2_+_179149636 0.505 ENST00000409631.1
 OSBPL6
oxysterol binding protein-like 6
chr7_-_130080977 0.502 ENST00000223208.5
 CEP41
centrosomal protein 41kDa
chr8_-_28347737 0.499 ENST00000517673.1
ENST00000518734.1
ENST00000346498.2
ENST00000380254.2
 FBXO16



F-box protein 16



chr17_-_16256718 0.485 ENST00000476243.1
ENST00000299736.4
 CENPV

centromere protein V

chr13_+_77522632 0.463 ENST00000377462.1
 IRG1
immunoresponsive 1 homolog (mouse)
chr2_-_120124258 0.462 ENST00000409877.1
ENST00000409523.1
ENST00000409466.2
ENST00000414534.1
 C2orf76



chromosome 2 open reading frame 76



chr1_-_28527152 0.405 ENST00000321830.5
 AL353354.1
Uncharacterized protein
chr6_-_25874440 0.393 ENST00000361703.6
ENST00000397060.4
 SLC17A3

solute carrier family 17 (organic anion transporter), member 3

chr3_+_94657118 0.369 ENST00000466089.1
ENST00000470465.1
 LINC00879

long intergenic non-protein coding RNA 879

chr9_-_13175823 0.353 ENST00000545857.1
 MPDZ
multiple PDZ domain protein
chr10_+_115674530 0.351 ENST00000451472.1
 AL162407.1
CDNA FLJ20147 fis, clone COL07954; HCG1781466; Uncharacterized protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0007368 determination of left/right symmetry(GO:0007368)
0.2 1.9 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 0.5 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.5 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.5 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.5 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.4 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.4 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.3 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.3 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.3 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.1 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0050428 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.0 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 0.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.9 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 1.9 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.6 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.4 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.3 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.3 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.0 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.3 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement