Motif ID: BBX

Z-value: 0.511


Transcription factors associated with BBX:

Gene SymbolEntrez IDGene Name
BBX ENSG00000114439.14 BBX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BBXhg19_v2_chr3_+_107241783_1072418500.414.9e-02Click!


Activity profile for motif BBX.

activity profile for motif BBX


Sorted Z-values histogram for motif BBX

Sorted Z-values for motif BBX



Network of associatons between targets according to the STRING database.



First level regulatory network of BBX

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_228735763 2.188 ENST00000373666.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr7_-_16921601 1.951 ENST00000402239.3
ENST00000310398.2
ENST00000414935.1
 AGR3


anterior gradient 3


chr20_-_7921090 1.892 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr11_+_60467047 1.271 ENST00000300226.2
 MS4A8
membrane-spanning 4-domains, subfamily A, member 8
chr1_-_161337662 1.181 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr1_-_216978709 0.586 ENST00000360012.3
 ESRRG
estrogen-related receptor gamma
chr4_-_123542224 0.545 ENST00000264497.3
 IL21
interleukin 21
chr2_-_62081148 0.533 ENST00000404929.1
 FAM161A
family with sequence similarity 161, member A
chr2_-_62081254 0.529 ENST00000405894.3
 FAM161A
family with sequence similarity 161, member A
chr2_+_179149636 0.505 ENST00000409631.1
 OSBPL6
oxysterol binding protein-like 6
chr7_-_130080977 0.502 ENST00000223208.5
 CEP41
centrosomal protein 41kDa
chr8_-_28347737 0.499 ENST00000517673.1
ENST00000518734.1
ENST00000346498.2
ENST00000380254.2
 FBXO16



F-box protein 16



chr17_-_16256718 0.485 ENST00000476243.1
ENST00000299736.4
 CENPV

centromere protein V

chr13_+_77522632 0.463 ENST00000377462.1
 IRG1
immunoresponsive 1 homolog (mouse)
chr2_-_120124258 0.462 ENST00000409877.1
ENST00000409523.1
ENST00000409466.2
ENST00000414534.1
 C2orf76



chromosome 2 open reading frame 76



chr1_-_28527152 0.405 ENST00000321830.5
 AL353354.1
Uncharacterized protein
chr6_-_25874440 0.393 ENST00000361703.6
ENST00000397060.4
 SLC17A3

solute carrier family 17 (organic anion transporter), member 3

chr3_+_94657118 0.369 ENST00000466089.1
ENST00000470465.1
 LINC00879

long intergenic non-protein coding RNA 879

chr9_-_13175823 0.353 ENST00000545857.1
 MPDZ
multiple PDZ domain protein
chr10_+_115674530 0.351 ENST00000451472.1
 AL162407.1
CDNA FLJ20147 fis, clone COL07954; HCG1781466; Uncharacterized protein
chr21_+_31768348 0.325 ENST00000355459.2
 KRTAP13-1
keratin associated protein 13-1
chr3_+_94657086 0.323 ENST00000463200.1
 LINC00879
long intergenic non-protein coding RNA 879
chr19_+_9361606 0.322 ENST00000456448.1
 OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr11_+_58390132 0.314 ENST00000361987.4
 CNTF
ciliary neurotrophic factor
chr6_+_31895254 0.311 ENST00000299367.5
ENST00000442278.2
 C2

complement component 2

chr17_+_40950900 0.297 ENST00000588527.1
 CNTD1
cyclin N-terminal domain containing 1
chr11_+_61717336 0.270 ENST00000378042.3
 BEST1
bestrophin 1
chrX_+_78426469 0.259 ENST00000276077.1
 GPR174
G protein-coupled receptor 174
chr2_+_102928009 0.259 ENST00000404917.2
ENST00000447231.1
 IL1RL1

interleukin 1 receptor-like 1

chr12_-_39734783 0.258 ENST00000552961.1
 KIF21A
kinesin family member 21A
chrX_-_102531717 0.257 ENST00000372680.1
 TCEAL5
transcription elongation factor A (SII)-like 5
chr11_+_61717279 0.248 ENST00000378043.4
 BEST1
bestrophin 1
chr3_-_112218205 0.225 ENST00000383680.4
 BTLA
B and T lymphocyte associated
chr4_-_987164 0.206 ENST00000398520.2
 SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr9_-_95166841 0.200 ENST00000262551.4
 OGN
osteoglycin
chr9_-_95166884 0.196 ENST00000375561.5
 OGN
osteoglycin
chr19_+_6887571 0.180 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
 EMR1




egf-like module containing, mucin-like, hormone receptor-like 1




chr6_-_133084580 0.179 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
 VNN2


vanin 2


chr6_-_29343068 0.178 ENST00000396806.3
 OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr3_+_111260856 0.169 ENST00000352690.4
 CD96
CD96 molecule
chr11_+_22689648 0.163 ENST00000278187.3
 GAS2
growth arrest-specific 2
chr4_-_159644507 0.159 ENST00000307720.3
 PPID
peptidylprolyl isomerase D
chr20_-_30310656 0.157 ENST00000376055.4
 BCL2L1
BCL2-like 1
chr6_-_49712123 0.155 ENST00000263045.4
 CRISP3
cysteine-rich secretory protein 3
chr16_-_28374829 0.140 ENST00000532254.1
 NPIPB6
nuclear pore complex interacting protein family, member B6
chr17_+_66255310 0.132 ENST00000448504.2
 ARSG
arylsulfatase G
chr20_-_30310693 0.130 ENST00000307677.4
ENST00000420653.1
 BCL2L1

BCL2-like 1

chr1_-_206785789 0.128 ENST00000437518.1
ENST00000367114.3
 EIF2D

eukaryotic translation initiation factor 2D

chr15_+_65823092 0.123 ENST00000566074.1
 PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr3_+_148583043 0.122 ENST00000296046.3
 CPA3
carboxypeptidase A3 (mast cell)
chr4_+_129349188 0.121 ENST00000511497.1
 RP11-420A23.1
RP11-420A23.1
chr4_-_104021009 0.120 ENST00000509245.1
ENST00000296424.4
 BDH2

3-hydroxybutyrate dehydrogenase, type 2

chrX_-_19817869 0.119 ENST00000379698.4
 SH3KBP1
SH3-domain kinase binding protein 1
chr12_-_100656134 0.117 ENST00000548313.1
 DEPDC4
DEP domain containing 4
chr1_-_153123345 0.109 ENST00000368748.4
 SPRR2G
small proline-rich protein 2G
chr5_+_125758813 0.108 ENST00000285689.3
ENST00000515200.1
 GRAMD3

GRAM domain containing 3

chr13_+_33160553 0.107 ENST00000315596.10
 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr5_+_140079919 0.106 ENST00000274712.3
 ZMAT2
zinc finger, matrin-type 2
chr1_+_229440129 0.102 ENST00000366688.3
 SPHAR
S-phase response (cyclin related)
chr10_-_94003003 0.101 ENST00000412050.4
 CPEB3
cytoplasmic polyadenylation element binding protein 3
chr14_+_57671888 0.099 ENST00000391612.1
 AL391152.1
AL391152.1
chr5_+_161494521 0.094 ENST00000356592.3
 GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr15_+_54305101 0.087 ENST00000260323.11
ENST00000545554.1
ENST00000537900.1
 UNC13C


unc-13 homolog C (C. elegans)


chr6_+_54173227 0.084 ENST00000259782.4
ENST00000370864.3
 TINAG

tubulointerstitial nephritis antigen

chr10_+_111765562 0.080 ENST00000360162.3
 ADD3
adducin 3 (gamma)
chr15_+_49715293 0.079 ENST00000267843.4
ENST00000560270.1
 FGF7

fibroblast growth factor 7

chr20_-_30310336 0.077 ENST00000434194.1
ENST00000376062.2
 BCL2L1

BCL2-like 1

chr16_+_28763108 0.074 ENST00000357796.3
ENST00000550983.1
 NPIPB9

nuclear pore complex interacting protein family, member B9

chr4_-_186697044 0.065 ENST00000437304.2
 SORBS2
sorbin and SH3 domain containing 2
chr4_-_186696425 0.063 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
 SORBS2


sorbin and SH3 domain containing 2


chr21_+_19617140 0.061 ENST00000299295.2
ENST00000338326.3
 CHODL

chondrolectin

chr3_-_112218378 0.060 ENST00000334529.5
 BTLA
B and T lymphocyte associated
chr3_+_51851612 0.052 ENST00000456080.1
 IQCF3
IQ motif containing F3
chr18_-_21017817 0.045 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
 TMEM241





transmembrane protein 241





chr7_-_16872932 0.043 ENST00000419572.2
ENST00000412973.1
 AGR2

anterior gradient 2

chr2_+_102927962 0.041 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
 IL1RL1

IL18R1
interleukin 1 receptor-like 1

interleukin 18 receptor 1
chr9_+_35161998 0.039 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
 UNC13B


unc-13 homolog B (C. elegans)


chr14_+_22337014 0.038 ENST00000390436.2
 TRAV13-1
T cell receptor alpha variable 13-1
chr14_+_75230011 0.038 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
 YLPM1


YLP motif containing 1


chr18_+_29769978 0.038 ENST00000269202.6
ENST00000581447.1
 MEP1B

meprin A, beta

chr14_+_22771851 0.031 ENST00000390466.1
 TRAV39
T cell receptor alpha variable 39
chr1_-_59043166 0.026 ENST00000371225.2
 TACSTD2
tumor-associated calcium signal transducer 2
chr4_-_113558014 0.023 ENST00000503172.1
ENST00000505019.1
ENST00000309071.5
 C4orf21


chromosome 4 open reading frame 21


chr3_-_168865522 0.019 ENST00000464456.1
 MECOM
MDS1 and EVI1 complex locus
chr4_+_88571429 0.016 ENST00000339673.6
ENST00000282479.7
 DMP1

dentin matrix acidic phosphoprotein 1

chr5_+_179921344 0.015 ENST00000261951.4
 CNOT6
CCR4-NOT transcription complex, subunit 6
chr3_+_122399444 0.014 ENST00000474629.2
 PARP14
poly (ADP-ribose) polymerase family, member 14
chr19_+_47421933 0.013 ENST00000404338.3
 ARHGAP35
Rho GTPase activating protein 35
chr2_+_63816295 0.012 ENST00000539945.1
ENST00000544381.1
 MDH1

malate dehydrogenase 1, NAD (soluble)

chr10_+_24497704 0.012 ENST00000376456.4
ENST00000458595.1
 KIAA1217

KIAA1217

chr9_-_5833027 0.012 ENST00000339450.5
 ERMP1
endoplasmic reticulum metallopeptidase 1
chr2_-_158182410 0.011 ENST00000419116.2
ENST00000410096.1
 ERMN

ermin, ERM-like protein

chr15_+_54901540 0.008 ENST00000539562.2
 UNC13C
unc-13 homolog C (C. elegans)
chr3_+_111260954 0.008 ENST00000283285.5
 CD96
CD96 molecule
chr11_+_118443098 0.008 ENST00000392859.3
ENST00000359415.4
ENST00000534182.2
ENST00000264028.4
 ARCN1



archain 1



chrX_-_119077695 0.004 ENST00000371410.3
 NKAP
NFKB activating protein
chr8_-_108510224 0.004 ENST00000517746.1
ENST00000297450.3
 ANGPT1

angiopoietin 1

chr4_+_174818390 0.001 ENST00000509968.1
ENST00000512263.1
 RP11-161D15.1

RP11-161D15.1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 0.5 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.3 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.1 0.5 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.3 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.1 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.0 0.4 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.5 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.5 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.4 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.3 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0050428 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.0 2.2 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.0 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 1.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 0.3 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.6 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 1.9 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.4 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.1 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.0 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.4 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes