Motif ID: BCL6B
Z-value: 0.506
Transcription factors associated with BCL6B:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| BCL6B | ENSG00000161940.6 | BCL6B |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BCL6B | hg19_v2_chr17_+_6926339_6926377 | 0.03 | 8.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.3 | 0.8 | GO:0019442 | tryptophan catabolic process to acetyl-CoA(GO:0019442) |
| 0.3 | 0.8 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
| 0.2 | 1.0 | GO:1905167 | receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.2 | 0.7 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 0.2 | 1.0 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.2 | 0.6 | GO:0046125 | thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125) |
| 0.1 | 1.3 | GO:0035502 | metanephric part of ureteric bud development(GO:0035502) |
| 0.1 | 0.9 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.1 | 0.3 | GO:0031247 | actin rod assembly(GO:0031247) |
| 0.1 | 0.8 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 0.9 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 0.4 | GO:0060298 | positive regulation of sarcomere organization(GO:0060298) |
| 0.1 | 0.5 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.1 | 0.4 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.1 | 0.2 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.1 | 0.3 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.1 | 0.3 | GO:0015862 | uridine transport(GO:0015862) |
| 0.1 | 0.3 | GO:0071034 | CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) |
| 0.1 | 0.4 | GO:0045359 | positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.0 | 0.2 | GO:0034140 | negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) |
| 0.0 | 0.2 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 0.0 | 0.2 | GO:0086021 | SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) |
| 0.0 | 0.2 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.0 | 0.5 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.0 | 0.1 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
| 0.0 | 0.3 | GO:0048840 | otolith development(GO:0048840) |
| 0.0 | 0.1 | GO:0071449 | cellular response to lipid hydroperoxide(GO:0071449) |
| 0.0 | 0.2 | GO:1902035 | positive regulation of hematopoietic stem cell proliferation(GO:1902035) |
| 0.0 | 0.9 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 1.3 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 0.2 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.0 | 0.1 | GO:0002290 | gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193) |
| 0.0 | 0.1 | GO:0071469 | detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469) |
| 0.0 | 0.5 | GO:0021670 | lateral ventricle development(GO:0021670) forebrain morphogenesis(GO:0048853) |
| 0.0 | 0.6 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.0 | 0.1 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.0 | 0.2 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.0 | 0.3 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.0 | 0.2 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) |
| 0.0 | 0.1 | GO:0000467 | exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467) U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear ncRNA surveillance(GO:0071029) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046) |
| 0.0 | 0.3 | GO:0015866 | ADP transport(GO:0015866) |
| 0.0 | 0.2 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.0 | 0.6 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.4 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.0 | 0.4 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
| 0.0 | 0.0 | GO:0006550 | isoleucine catabolic process(GO:0006550) |
| 0.0 | 0.1 | GO:0001994 | norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994) |
| 0.0 | 0.1 | GO:0086073 | protein localization to adherens junction(GO:0071896) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.0 | 0.1 | GO:0045627 | positive regulation of T-helper 1 cell differentiation(GO:0045627) |
| 0.0 | 1.1 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.2 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:1990666 | PCSK9-LDLR complex(GO:1990666) |
| 0.1 | 1.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 1.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 0.2 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.0 | 0.3 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.3 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.0 | 0.3 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.2 | GO:0031417 | NatC complex(GO:0031417) |
| 0.0 | 0.8 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.5 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.0 | 0.3 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.4 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.0 | 0.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.2 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.0 | 0.3 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 1.3 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.1 | GO:0005916 | fascia adherens(GO:0005916) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.2 | 0.9 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.2 | 0.7 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 0.2 | 0.6 | GO:0004797 | thymidine kinase activity(GO:0004797) |
| 0.1 | 1.0 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.1 | 0.8 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 0.1 | 0.4 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.1 | 1.0 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.1 | 0.9 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 0.2 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.1 | 0.4 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 0.4 | GO:0070728 | leucine binding(GO:0070728) |
| 0.1 | 1.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.3 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.0 | 0.1 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.0 | 0.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 1.1 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.2 | GO:0022850 | serotonin-gated cation channel activity(GO:0022850) |
| 0.0 | 0.3 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.0 | 0.2 | GO:0086020 | gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) |
| 0.0 | 0.1 | GO:0098782 | mechanically-gated potassium channel activity(GO:0098782) |
| 0.0 | 0.3 | GO:0046790 | virion binding(GO:0046790) |
| 0.0 | 0.4 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.0 | 1.6 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 0.2 | GO:0016972 | thiol oxidase activity(GO:0016972) |
| 0.0 | 3.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.5 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857) |
| 0.0 | 0.5 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.1 | GO:0030107 | HLA-A specific inhibitory MHC class I receptor activity(GO:0030107) |
| 0.0 | 0.3 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 0.1 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
| 0.0 | 0.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.3 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.0 | 0.1 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 0.3 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.0 | 0.3 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 0.4 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.0 | 0.1 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.0 | 0.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.1 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.0 | 0.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.5 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.0 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.9 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.0 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.9 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.6 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.0 | 0.5 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.5 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
| 0.1 | 1.8 | REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 2.5 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.8 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 1.0 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.5 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 0.5 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.9 | REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 0.3 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.3 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.8 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.8 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.1 | REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.0 | 0.6 | REACTOME_PYRIMIDINE_METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 1.1 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.5 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.6 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
