Motif ID: BCL6B

Z-value: 0.506


Transcription factors associated with BCL6B:

Gene SymbolEntrez IDGene Name
BCL6B ENSG00000161940.6 BCL6B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BCL6Bhg19_v2_chr17_+_6926339_69263770.038.7e-01Click!


Activity profile for motif BCL6B.

activity profile for motif BCL6B


Sorted Z-values histogram for motif BCL6B

Sorted Z-values for motif BCL6B



Network of associatons between targets according to the STRING database.



First level regulatory network of BCL6B

PNG image of the network

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Top targets:


Showing 1 to 20 of 187 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_8975061 2.570 ENST00000299698.7
A2ML1
alpha-2-macroglobulin-like 1
chr4_+_69313145 1.639 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr2_-_216257849 1.588 ENST00000456923.1
FN1
fibronectin 1
chr8_-_91095099 1.339 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr2_-_31361543 1.060 ENST00000349752.5
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr19_+_11200038 0.977 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR





low density lipoprotein receptor





chr1_-_153521597 0.919 ENST00000368712.1
S100A3
S100 calcium binding protein A3
chr19_+_44037546 0.835 ENST00000601282.1
ZNF575
zinc finger protein 575
chr7_+_134464376 0.816 ENST00000454108.1
ENST00000361675.2
CALD1

caldesmon 1

chr7_+_134464414 0.802 ENST00000361901.2
CALD1
caldesmon 1
chr1_+_84609944 0.795 ENST00000370685.3
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_153521714 0.787 ENST00000368713.3
S100A3
S100 calcium binding protein A3
chr12_-_10007448 0.731 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chrX_-_153775426 0.652 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr4_-_99578776 0.650 ENST00000515287.1
TSPAN5
tetraspanin 5
chr17_-_76183111 0.646 ENST00000405273.1
ENST00000590862.1
ENST00000590430.1
ENST00000586613.1
TK1



thymidine kinase 1, soluble



chr4_-_99578789 0.642 ENST00000511651.1
ENST00000505184.1
TSPAN5

tetraspanin 5

chr15_+_40886199 0.635 ENST00000346991.5
ENST00000528975.1
ENST00000527044.1
CASC5


cancer susceptibility candidate 5


chr20_+_58251716 0.631 ENST00000355648.4
PHACTR3
phosphatase and actin regulator 3
chr11_+_18230685 0.582 ENST00000340135.3
ENST00000534640.1
RP11-113D6.10

Putative mitochondrial carrier protein LOC494141


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.6 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 1.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 1.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 1.1 GO:0016266 O-glycan processing(GO:0016266)
0.2 1.0 GO:1905167 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.2 1.0 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.9 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.9 GO:0030488 tRNA methylation(GO:0030488)
0.3 0.8 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.3 0.8 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.1 0.8 GO:0097338 response to clozapine(GO:0097338)
0.2 0.7 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.2 0.6 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.6 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.5 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.5 GO:0044351 macropinocytosis(GO:0044351)
0.0 0.5 GO:0021670 lateral ventricle development(GO:0021670) forebrain morphogenesis(GO:0048853)
0.1 0.4 GO:0060298 positive regulation of sarcomere organization(GO:0060298)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.6 GO:0030478 actin cap(GO:0030478)
0.0 1.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.3 GO:0043195 terminal bouton(GO:0043195)
0.3 1.0 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.0 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.4 GO:0097342 ripoptosome(GO:0097342)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.2 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.0 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 1.6 GO:0016504 peptidase activator activity(GO:0016504)
0.3 1.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 1.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 1.0 GO:0051525 NFAT protein binding(GO:0051525)
0.2 0.9 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.8 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 0.7 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.2 0.6 GO:0004797 thymidine kinase activity(GO:0004797)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.0 0.5 GO:0070628 proteasome binding(GO:0070628)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.1 0.4 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.4 GO:0070728 leucine binding(GO:0070728)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.0 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.9 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID_IGF1_PATHWAY IGF1 pathway
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.8 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.6 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 1.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.9 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.8 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.8 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.6 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.5 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.3 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.1 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex