Motif ID: BHLHE22_BHLHA15_BHLHE23

Z-value: 0.574

Transcription factors associated with BHLHE22_BHLHA15_BHLHE23:

Gene SymbolEntrez IDGene Name
BHLHA15 ENSG00000180535.3 BHLHA15
BHLHE22 ENSG00000180828.1 BHLHE22
BHLHE23 ENSG00000125533.4 BHLHE23

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BHLHE22hg19_v2_chr8_+_65492756_65492814-0.029.3e-01Click!


Activity profile for motif BHLHE22_BHLHA15_BHLHE23.

activity profile for motif BHLHE22_BHLHA15_BHLHE23


Sorted Z-values histogram for motif BHLHE22_BHLHA15_BHLHE23

Sorted Z-values for motif BHLHE22_BHLHA15_BHLHE23



Network of associatons between targets according to the STRING database.



First level regulatory network of BHLHE22_BHLHA15_BHLHE23

PNG image of the network

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Top targets:


Showing 1 to 20 of 134 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_163148161 2.516 ENST00000337019.3
ENST00000366889.2
 PACRG

PARK2 co-regulated

chr1_+_104293028 2.101 ENST00000370079.3
 AMY1C
amylase, alpha 1C (salivary)
chr1_+_244214577 2.072 ENST00000358704.4
 ZBTB18
zinc finger and BTB domain containing 18
chr1_+_95975672 1.890 ENST00000440116.2
ENST00000456933.1
 RP11-286B14.1

RP11-286B14.1

chr15_-_65503801 1.692 ENST00000261883.4
 CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr3_-_121379739 1.424 ENST00000428394.2
ENST00000314583.3
 HCLS1

hematopoietic cell-specific Lyn substrate 1

chr1_+_47489240 1.356 ENST00000371901.3
 CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr5_-_111312622 1.292 ENST00000395634.3
 NREP
neuronal regeneration related protein
chr6_+_135502501 1.179 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
 MYB






v-myb avian myeloblastosis viral oncogene homolog






chr3_-_114477962 1.123 ENST00000471418.1
 ZBTB20
zinc finger and BTB domain containing 20
chr15_-_98417780 1.087 ENST00000503874.3
 LINC00923
long intergenic non-protein coding RNA 923
chr3_-_114477787 1.054 ENST00000464560.1
 ZBTB20
zinc finger and BTB domain containing 20
chr7_-_99573677 0.770 ENST00000292401.4
 AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr1_+_61330931 0.680 ENST00000371191.1
 NFIA
nuclear factor I/A
chr19_+_56368803 0.665 ENST00000587891.1
 NLRP4
NLR family, pyrin domain containing 4
chr16_-_69385681 0.602 ENST00000288025.3
 TMED6
transmembrane emp24 protein transport domain containing 6
chr9_-_130635741 0.581 ENST00000223836.10
 AK1
adenylate kinase 1
chr2_+_186603355 0.578 ENST00000343098.5
 FSIP2
fibrous sheath interacting protein 2
chr4_-_70505358 0.542 ENST00000457664.2
ENST00000604629.1
ENST00000604021.1
 UGT2A2


UDP glucuronosyltransferase 2 family, polypeptide A2


chr4_+_160188889 0.537 ENST00000264431.4
 RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0007286 spermatid development(GO:0007286)
0.0 2.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 1.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 1.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.4 1.2 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 0.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.7 GO:0072189 ureter development(GO:0072189)
0.2 0.5 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.1 0.4 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.4 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.4 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.4 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 0.3 GO:0032240 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.1 0.3 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.3 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.3 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 0.2 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.4 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.3 GO:0031251 PAN complex(GO:0031251)
0.0 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 0.2 GO:0044754 autolysosome(GO:0044754)
0.0 0.1 GO:0043159 acrosomal matrix(GO:0043159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 1.4 GO:0070330 aromatase activity(GO:0070330)
0.1 1.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.8 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.6 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.5 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.1 0.4 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.2 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.2 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0022884 macromolecule transmembrane transporter activity(GO:0022884)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors