Motif ID: BRCA1

Z-value: 0.392


Transcription factors associated with BRCA1:

Gene SymbolEntrez IDGene Name
BRCA1 ENSG00000012048.15 BRCA1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277317_41277348-0.405.5e-02Click!


Activity profile for motif BRCA1.

activity profile for motif BRCA1


Sorted Z-values histogram for motif BRCA1

Sorted Z-values for motif BRCA1



Network of associatons between targets according to the STRING database.



First level regulatory network of BRCA1

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_55888186 1.505 ENST00000291934.3
 TMEM190
transmembrane protein 190
chr20_+_9049682 1.361 ENST00000334005.3
ENST00000378473.3
 PLCB4

phospholipase C, beta 4

chr20_+_31749574 0.808 ENST00000253362.2
 BPIFA2
BPI fold containing family A, member 2
chr7_-_6010263 0.667 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
 RSPH10B



radial spoke head 10 homolog B (Chlamydomonas)



chr1_-_160232312 0.650 ENST00000440682.1
 DCAF8
DDB1 and CUL4 associated factor 8
chr8_+_37553261 0.634 ENST00000331569.4
 ZNF703
zinc finger protein 703
chr17_-_42019836 0.609 ENST00000225992.3
 PPY
pancreatic polypeptide
chr5_+_140186647 0.607 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
 PCDHA4


protocadherin alpha 4


chr6_+_16129308 0.606 ENST00000356840.3
ENST00000349606.4
 MYLIP

myosin regulatory light chain interacting protein

chr1_-_227505289 0.486 ENST00000366765.3
 CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr20_+_52105495 0.473 ENST00000439873.2
 AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr9_-_124976154 0.457 ENST00000482062.1
 LHX6
LIM homeobox 6
chr6_+_12717892 0.429 ENST00000379350.1
 PHACTR1
phosphatase and actin regulator 1
chr8_-_72459885 0.382 ENST00000523987.1
 RP11-1102P16.1
Uncharacterized protein
chr13_-_99910673 0.364 ENST00000397473.2
ENST00000397470.2
 GPR18

G protein-coupled receptor 18

chr11_-_119234876 0.335 ENST00000525735.1
 USP2
ubiquitin specific peptidase 2
chr10_-_61900762 0.314 ENST00000355288.2
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr5_+_139027877 0.279 ENST00000302517.3
 CXXC5
CXXC finger protein 5
chrX_-_10851762 0.278 ENST00000380785.1
ENST00000380787.1
 MID1

midline 1 (Opitz/BBB syndrome)

chr12_-_49449107 0.261 ENST00000301067.7
 KMT2D
lysine (K)-specific methyltransferase 2D

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 0.6 GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.0 0.6 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.6 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.4 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.1 0.3 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.3 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.2 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.1 0.2 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.0 0.2 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.2 GO:0061009 common bile duct development(GO:0061009)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:0001555 oocyte growth(GO:0001555)
0.0 0.2 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.5 GO:0002079 inner acrosomal membrane(GO:0002079)
0.0 1.4 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.2 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0097361 CIA complex(GO:0097361)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0043621 protein self-association(GO:0043621)
0.0 1.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.7 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0070404 NADH binding(GO:0070404)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events