Motif ID: CBFB

Z-value: 0.383


Transcription factors associated with CBFB:

Gene SymbolEntrez IDGene Name
CBFB ENSG00000067955.9 CBFB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CBFBhg19_v2_chr16_+_67062996_670630190.377.6e-02Click!


Activity profile for motif CBFB.

activity profile for motif CBFB


Sorted Z-values histogram for motif CBFB

Sorted Z-values for motif CBFB



Network of associatons between targets according to the STRING database.



First level regulatory network of CBFB

PNG image of the network

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Top targets:


Showing 1 to 20 of 74 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_44637526 0.921 ENST00000372330.3
 MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr14_+_85996471 0.640 ENST00000330753.4
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr5_-_39203093 0.484 ENST00000515010.1
 FYB
FYN binding protein
chr19_-_14049184 0.418 ENST00000339560.5
 PODNL1
podocan-like 1
chr20_+_62492566 0.415 ENST00000369916.3
 ABHD16B
abhydrolase domain containing 16B
chr19_-_14048804 0.394 ENST00000254320.3
ENST00000586075.1
 PODNL1

podocan-like 1

chr1_+_47264711 0.357 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
 CYP4B1


cytochrome P450, family 4, subfamily B, polypeptide 1


chr2_-_158300556 0.347 ENST00000264192.3
 CYTIP
cytohesin 1 interacting protein
chr14_+_85996507 0.331 ENST00000554746.1
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr6_-_34524049 0.281 ENST00000374037.3
 SPDEF
SAM pointed domain containing ETS transcription factor
chr11_-_58343319 0.268 ENST00000395074.2
 LPXN
leupaxin
chr6_-_34524093 0.260 ENST00000544425.1
 SPDEF
SAM pointed domain containing ETS transcription factor
chr3_-_99569821 0.246 ENST00000487087.1
 FILIP1L
filamin A interacting protein 1-like
chr1_-_52499443 0.233 ENST00000371614.1
 KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr20_+_43343886 0.214 ENST00000190983.4
 WISP2
WNT1 inducible signaling pathway protein 2
chr11_-_66103867 0.203 ENST00000424433.2
 RIN1
Ras and Rab interactor 1
chr11_+_114310164 0.200 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
 REXO2


RNA exonuclease 2


chr8_-_60031762 0.200 ENST00000361421.1
 TOX
thymocyte selection-associated high mobility group box
chr1_-_179112173 0.198 ENST00000408940.3
ENST00000504405.1
 ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr14_-_85996332 0.184 ENST00000380722.1
 RP11-497E19.1
RP11-497E19.1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.0 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.9 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0 0.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.5 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.5 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.4 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.2 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.1 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.1 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0070560 protein secretion by platelet(GO:0070560)

Gene overrepresentation in cellular_component category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)

Gene overrepresentation in molecular_function category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0036361 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions