Motif ID: CDC5L

Z-value: 1.019


Transcription factors associated with CDC5L:

Gene SymbolEntrez IDGene Name
CDC5L ENSG00000096401.7 CDC5L

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CDC5Lhg19_v2_chr6_+_44355257_443553150.116.1e-01Click!


Activity profile for motif CDC5L.

activity profile for motif CDC5L


Sorted Z-values histogram for motif CDC5L

Sorted Z-values for motif CDC5L



Network of associatons between targets according to the STRING database.



First level regulatory network of CDC5L

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_16921601 5.628 ENST00000402239.3
ENST00000310398.2
ENST00000414935.1
 AGR3


anterior gradient 3


chr6_-_32557610 4.906 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr16_+_80574854 3.664 ENST00000305904.6
ENST00000568035.1
 DYNLRB2

dynein, light chain, roadblock-type 2

chr6_-_32498046 3.204 ENST00000374975.3
 HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr1_+_38022572 3.134 ENST00000541606.1
 DNALI1
dynein, axonemal, light intermediate chain 1
chr5_+_94727048 2.845 ENST00000283357.5
 FAM81B
family with sequence similarity 81, member B
chr4_-_100356844 2.781 ENST00000437033.2
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr5_-_35938674 2.615 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr1_+_38022513 2.571 ENST00000296218.7
 DNALI1
dynein, axonemal, light intermediate chain 1
chr6_+_131958436 2.434 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
 ENPP3



ectonucleotide pyrophosphatase/phosphodiesterase 3



chr6_-_33041378 2.354 ENST00000428995.1
 HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr17_+_45908974 2.305 ENST00000269025.4
 LRRC46
leucine rich repeat containing 46
chr19_-_9006766 2.294 ENST00000599436.1
 MUC16
mucin 16, cell surface associated
chr10_+_115511213 2.185 ENST00000361048.1
 PLEKHS1
pleckstrin homology domain containing, family S member 1
chr11_+_73661364 2.046 ENST00000339764.1
 DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr12_+_20963647 2.011 ENST00000381545.3
 SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr12_+_20963632 1.963 ENST00000540853.1
ENST00000261196.2
 SLCO1B3

solute carrier organic anion transporter family, member 1B3

chr1_-_150738261 1.853 ENST00000448301.2
ENST00000368985.3
 CTSS

cathepsin S

chr13_+_50589390 1.849 ENST00000360473.4
ENST00000312942.1
 KCNRG

potassium channel regulator

chr6_+_32709119 1.780 ENST00000374940.3
 HLA-DQA2
major histocompatibility complex, class II, DQ alpha 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.2 7.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 5.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.8 5.3 GO:0010430 fatty acid omega-oxidation(GO:0010430)
1.0 4.9 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.1 4.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 2.5 GO:0016266 O-glycan processing(GO:0016266)
0.8 2.4 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 2.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 2.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.3 2.2 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.4 2.0 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 1.9 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 1.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.5 1.6 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.5 1.6 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.1 1.6 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.5 1.5 GO:0070839 divalent metal ion export(GO:0070839)
0.5 1.5 GO:0006711 estrogen catabolic process(GO:0006711)
0.2 1.5 GO:0006572 tyrosine catabolic process(GO:0006572)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 7.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 5.9 GO:0030286 dynein complex(GO:0030286)
0.3 3.7 GO:0036157 outer dynein arm(GO:0036157)
0.1 2.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.3 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.3 1.9 GO:0036021 endolysosome lumen(GO:0036021)
0.0 1.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.4 GO:0005813 centrosome(GO:0005813)
0.2 1.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 1.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.9 GO:0031519 PcG protein complex(GO:0031519)
0.3 0.8 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 0.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.7 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.6 GO:0001533 cornified envelope(GO:0001533)
0.0 0.6 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.5 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.5 GO:0098576 lumenal side of membrane(GO:0098576)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.1 GO:0042605 peptide antigen binding(GO:0042605)
0.3 7.8 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 5.8 GO:0045504 dynein heavy chain binding(GO:0045504)
1.3 5.3 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.3 4.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 3.8 GO:0002162 dystroglycan binding(GO:0002162)
0.1 3.8 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 2.8 GO:0043394 proteoglycan binding(GO:0043394)
0.5 2.4 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.2 2.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 2.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 2.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 1.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 1.6 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.1 1.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 1.5 GO:0050294 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.2 1.5 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 1.5 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 1.5 GO:0030507 spectrin binding(GO:0030507)
0.2 1.4 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 2.3 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 2.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.4 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.2 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 12.1 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4 5.3 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.3 5.0 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.4 3.2 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.2 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 1.9 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.9 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 1.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.4 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 1.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.1 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.0 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.9 REACTOME_REGULATION_OF_APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.7 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells