Motif ID: CDX1

Z-value: 0.855


Transcription factors associated with CDX1:

Gene SymbolEntrez IDGene Name
CDX1 ENSG00000113722.12 CDX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CDX1hg19_v2_chr5_+_149546334_149546364-0.433.7e-02Click!


Activity profile for motif CDX1.

activity profile for motif CDX1


Sorted Z-values histogram for motif CDX1

Sorted Z-values for motif CDX1



Network of associatons between targets according to the STRING database.



First level regulatory network of CDX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_34397800 6.804 ENST00000297623.2
 C9orf24
chromosome 9 open reading frame 24
chr4_-_16085340 3.991 ENST00000508167.1
 PROM1
prominin 1
chr4_-_16085314 3.961 ENST00000510224.1
 PROM1
prominin 1
chr4_-_100356844 3.606 ENST00000437033.2
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr10_-_69597915 2.501 ENST00000225171.2
 DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr9_-_138391692 2.462 ENST00000429260.2
 C9orf116
chromosome 9 open reading frame 116
chr5_+_140602904 1.758 ENST00000515856.2
ENST00000239449.4
 PCDHB14

protocadherin beta 14

chr10_-_28270795 1.702 ENST00000545014.1
 ARMC4
armadillo repeat containing 4
chr2_+_233527443 1.398 ENST00000410095.1
 EFHD1
EF-hand domain family, member D1
chr19_+_41594377 1.392 ENST00000330436.3
 CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr4_-_110723194 1.387 ENST00000394635.3
 CFI
complement factor I
chr5_+_140254884 1.365 ENST00000398631.2
 PCDHA12
protocadherin alpha 12
chr1_+_47489240 1.363 ENST00000371901.3
 CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr1_+_104159999 1.310 ENST00000414303.2
ENST00000423678.1
 AMY2A

amylase, alpha 2A (pancreatic)

chr8_+_76452097 1.259 ENST00000396423.2
 HNF4G
hepatocyte nuclear factor 4, gamma
chr6_-_110011704 1.223 ENST00000448084.2
 AK9
adenylate kinase 9
chr21_-_43735628 1.219 ENST00000291525.10
ENST00000518498.1
 TFF3

trefoil factor 3 (intestinal)

chr5_+_140165876 1.216 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
 PCDHA1


protocadherin alpha 1


chr10_+_114169299 1.193 ENST00000369410.3
 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_25801478 1.185 ENST00000540106.1
ENST00000445693.1
ENST00000545543.1
ENST00000542224.1
 IFLTD1



intermediate filament tail domain containing 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 8.0 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
1.5 4.4 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 3.3 GO:0030449 regulation of complement activation(GO:0030449)
0.1 2.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 2.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.7 2.0 GO:0006174 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.1 1.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.7 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.2 1.6 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 1.6 GO:0035082 axoneme assembly(GO:0035082)
0.2 1.4 GO:0009804 coumarin metabolic process(GO:0009804)
0.2 1.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 1.2 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 1.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.4 1.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 1.1 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.2 1.0 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 1.0 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 1.0 GO:0006600 creatine metabolic process(GO:0006600)
0.0 1.0 GO:0002467 germinal center formation(GO:0002467)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.7 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 1.5 GO:0032982 myosin filament(GO:0032982)
0.0 1.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 1.0 GO:0097255 R2TP complex(GO:0097255)
0.1 0.9 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.9 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.7 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.5 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 GO:0042805 actinin binding(GO:0042805)
1.1 4.4 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 2.8 GO:0070330 aromatase activity(GO:0070330)
0.0 2.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 2.0 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.1 1.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.3 GO:0016160 amylase activity(GO:0016160)
0.0 1.3 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 1.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 1.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 1.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 1.0 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 1.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.9 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 0.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 0.8 GO:0019959 interleukin-8 binding(GO:0019959)
0.0 0.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.2 3.4 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 1.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.4 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.1 1.3 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.2 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.1 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 0.9 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.8 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.8 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 0.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME_OPSINS Genes involved in Opsins
0.0 0.4 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1