Motif ID: CEBPA
Z-value: 1.106
Transcription factors associated with CEBPA:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| CEBPA | ENSG00000245848.2 | CEBPA |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPA | hg19_v2_chr19_-_33793430_33793470 | 0.59 | 2.3e-03 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 170 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.0 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 0.5 | 5.9 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.1 | 5.7 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.2 | 4.3 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 3.2 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.2 | 3.0 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.0 | 2.6 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.1 | 2.0 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.6 | 1.9 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 0.1 | 1.9 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.6 | 1.8 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.4 | 1.8 | GO:0015891 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.1 | 1.8 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.1 | 1.7 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.3 | 1.6 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.1 | 1.5 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.3 | 1.4 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.1 | 1.4 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 1.4 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.4 | 1.3 | GO:0001798 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 44 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 5.8 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 4.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 4.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 1.8 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 1.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 1.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.9 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 0.8 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.7 | GO:0071556 | integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.0 | 0.7 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.6 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.5 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.5 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 0.4 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.1 | 0.4 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.0 | 0.4 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 0.4 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.0 | 0.4 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 106 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.3 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 1.5 | 5.9 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.2 | 5.5 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 5.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 4.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 3.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.2 | 3.0 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.1 | 2.8 | GO:0001848 | complement binding(GO:0001848) |
| 0.6 | 2.5 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
| 0.0 | 2.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 2.0 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.5 | 1.8 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.4 | 1.8 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.2 | 1.7 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 1.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.6 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 1.6 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 1.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.2 | 1.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 1.3 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 21 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.6 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 4.2 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.7 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.2 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 2.1 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 2.0 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 1.4 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.3 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.2 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.2 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.0 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.0 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.9 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.9 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.5 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.4 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.4 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.0 | 0.3 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.3 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 31 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.2 | 4.6 | REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 3.6 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 2.7 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 2.4 | REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 1.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.7 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 1.6 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 1.5 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.3 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 1.2 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 1.2 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 1.2 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 1.0 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.9 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.9 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 0.8 | REACTOME_OPSINS | Genes involved in Opsins |
| 0.0 | 0.8 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.8 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.7 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
