Motif ID: CEBPB

Z-value: 1.353


Transcription factors associated with CEBPB:

Gene SymbolEntrez IDGene Name
CEBPB ENSG00000172216.4 CEBPB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CEBPBhg19_v2_chr20_+_48807351_48807384-0.223.0e-01Click!


Activity profile for motif CEBPB.

activity profile for motif CEBPB


Sorted Z-values histogram for motif CEBPB

Sorted Z-values for motif CEBPB



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPB

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_361890 7.649 ENST00000449710.1
ENST00000422053.2
 TRIB3

tribbles pseudokinase 3

chr20_+_361261 7.614 ENST00000217233.3
 TRIB3
tribbles pseudokinase 3
chr4_-_139163491 6.150 ENST00000280612.5
 SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr2_+_113885138 5.571 ENST00000409930.3
 IL1RN
interleukin 1 receptor antagonist
chr15_-_80263506 4.719 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr11_-_102668879 4.544 ENST00000315274.6
 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr12_-_25102252 4.223 ENST00000261192.7
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr2_-_216300784 3.668 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr12_-_25101920 3.399 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr3_+_42897512 2.818 ENST00000493193.1
 ACKR2
atypical chemokine receptor 2
chr18_+_29027696 2.791 ENST00000257189.4
 DSG3
desmoglein 3
chr19_-_36004543 2.678 ENST00000339686.3
ENST00000447113.2
ENST00000440396.1
 DMKN


dermokine


chr12_+_57624119 2.616 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
 SHMT2



serine hydroxymethyltransferase 2 (mitochondrial)



chr21_-_44495919 2.602 ENST00000398158.1
 CBS
cystathionine-beta-synthase
chr12_+_57624085 2.445 ENST00000553474.1
 SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr6_+_151187074 2.435 ENST00000367308.4
 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr12_-_95510743 2.289 ENST00000551521.1
 FGD6
FYVE, RhoGEF and PH domain containing 6
chr21_-_44495964 2.269 ENST00000398168.1
ENST00000398165.3
 CBS

cystathionine-beta-synthase

chr12_+_57623477 2.223 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
 SHMT2


serine hydroxymethyltransferase 2 (mitochondrial)


chr12_+_57623869 2.208 ENST00000414700.3
ENST00000557703.1
 SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.3 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
1.4 9.5 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
1.3 7.6 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.6 5.6 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
1.6 4.9 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.2 4.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 4.5 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
1.1 4.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 4.0 GO:0070268 cornification(GO:0070268)
0.2 3.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
1.2 3.7 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.7 3.4 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.4 2.7 GO:1903575 cornified envelope assembly(GO:1903575)
0.9 2.6 GO:0070512 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.6 2.5 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.4 2.5 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 2.5 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 2.4 GO:0015914 phospholipid transport(GO:0015914)
0.3 2.2 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.7 2.1 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 9.5 GO:0070552 BRISC complex(GO:0070552)
0.0 7.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 6.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 4.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.3 4.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 3.6 GO:0055037 recycling endosome(GO:0055037)
0.0 3.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.0 GO:0001726 ruffle(GO:0001726)
0.1 2.8 GO:0030057 desmosome(GO:0030057)
0.6 2.6 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.8 2.5 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.1 2.1 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 2.1 GO:0097228 sperm principal piece(GO:0097228)
0.0 2.0 GO:0005882 intermediate filament(GO:0005882)
0.2 1.9 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.7 GO:0001533 cornified envelope(GO:0001533)
0.0 1.7 GO:0015030 Cajal body(GO:0015030)
0.0 1.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.5 GO:0005915 zonula adherens(GO:0005915)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 15.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
1.4 9.5 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
1.6 8.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
1.3 7.6 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
1.9 5.6 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
1.6 4.9 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.2 4.7 GO:0051400 BH domain binding(GO:0051400)
1.1 4.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 3.7 GO:0016504 peptidase activator activity(GO:0016504)
0.7 3.4 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 3.1 GO:0050681 androgen receptor binding(GO:0050681)
0.2 2.8 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 2.7 GO:0050692 DBD domain binding(GO:0050692)
0.6 2.5 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.5 2.5 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.3 2.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.4 2.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.7 2.1 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.2 2.1 GO:0008430 selenium binding(GO:0008430)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 5.6 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 4.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 4.7 PID_BCR_5PATHWAY BCR signaling pathway
0.1 3.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.6 PID_BARD1_PATHWAY BARD1 signaling events
0.0 2.0 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.8 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.0 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.6 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 PID_CONE_PATHWAY Visual signal transduction: Cones

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 15.3 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.3 12.9 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.2 8.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 7.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 5.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 5.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 4.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 3.5 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 2.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 2.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.6 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.9 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.7 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.2 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha