Motif ID: CEBPE_CEBPD

Z-value: 1.082

Transcription factors associated with CEBPE_CEBPD:

Gene SymbolEntrez IDGene Name
CEBPD ENSG00000221869.4 CEBPD
CEBPE ENSG00000092067.5 CEBPE

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CEBPDhg19_v2_chr8_-_48651648_486516480.836.2e-07Click!
CEBPEhg19_v2_chr14_-_23588816_235888360.443.0e-02Click!


Activity profile for motif CEBPE_CEBPD.

activity profile for motif CEBPE_CEBPD


Sorted Z-values histogram for motif CEBPE_CEBPD

Sorted Z-values for motif CEBPE_CEBPD



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPE_CEBPD

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_216300784 5.223 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr1_-_186649543 4.592 ENST00000367468.5
 PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr8_-_6735451 4.009 ENST00000297439.3
 DEFB1
defensin, beta 1
chr2_-_113594279 3.836 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B


interleukin 1, beta


chr8_+_124194875 2.860 ENST00000522648.1
ENST00000276699.6
 FAM83A

family with sequence similarity 83, member A

chr8_+_124194752 2.778 ENST00000318462.6
 FAM83A
family with sequence similarity 83, member A
chr2_-_31637560 2.649 ENST00000379416.3
 XDH
xanthine dehydrogenase
chr9_-_94186131 2.554 ENST00000297689.3
 NFIL3
nuclear factor, interleukin 3 regulated
chr20_+_33759854 2.013 ENST00000216968.4
 PROCR
protein C receptor, endothelial
chr2_+_113885138 1.985 ENST00000409930.3
 IL1RN
interleukin 1 receptor antagonist
chr20_-_52790512 1.862 ENST00000216862.3
 CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr12_-_123201337 1.687 ENST00000528880.2
 HCAR3
hydroxycarboxylic acid receptor 3
chr12_-_123187890 1.678 ENST00000328880.5
 HCAR2
hydroxycarboxylic acid receptor 2
chr14_+_20937538 1.652 ENST00000361505.5
ENST00000553591.1
 PNP

purine nucleoside phosphorylase

chr16_-_84651647 1.585 ENST00000564057.1
 COTL1
coactosin-like 1 (Dictyostelium)
chr16_-_84651673 1.513 ENST00000262428.4
 COTL1
coactosin-like 1 (Dictyostelium)
chr4_-_139163491 1.396 ENST00000280612.5
 SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr11_-_18270182 1.347 ENST00000528349.1
ENST00000526900.1
ENST00000529528.1
ENST00000414546.2
ENST00000256733.4
 SAA2




serum amyloid A2




chr7_-_121944491 1.333 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
 FEZF1


FEZ family zinc finger 1


chr1_+_154377669 1.312 ENST00000368485.3
ENST00000344086.4
 IL6R

interleukin 6 receptor


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
1.7 5.2 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.5 4.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
1.3 4.0 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.1 4.0 GO:0006953 acute-phase response(GO:0006953)
1.3 3.8 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.7 2.6 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 2.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.4 2.4 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 2.1 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.2 2.0 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.6 1.9 GO:0002384 hepatic immune response(GO:0002384)
0.6 1.9 GO:0042369 vitamin D catabolic process(GO:0042369)
0.8 1.7 GO:0046102 inosine metabolic process(GO:0046102)
0.3 1.7 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.2 1.7 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 1.7 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 1.6 GO:0050832 defense response to fungus(GO:0050832)
0.0 1.4 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.2 1.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 4.1 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
1.0 4.0 GO:1990742 microvesicle(GO:1990742)
0.0 3.8 GO:0005901 caveola(GO:0005901)
0.0 3.4 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 2.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 2.4 GO:0043195 terminal bouton(GO:0043195)
0.5 1.9 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 1.3 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 0.9 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.1 0.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 0.6 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.0 0.5 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.6 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
1.1 4.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 4.1 GO:0016504 peptidase activator activity(GO:0016504)
1.3 4.0 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 3.9 GO:0042056 chemoattractant activity(GO:0042056)
0.2 3.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 2.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3 2.6 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.5 2.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 2.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.5 2.1 GO:0004074 biliverdin reductase activity(GO:0004074)
0.7 2.0 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.4 1.9 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.6 1.7 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.3 1.6 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.2 1.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.3 1.4 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.4 1.3 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.1 0.9 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 5.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 4.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 3.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 0.9 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.7 PID_FOXO_PATHWAY FoxO family signaling
0.1 0.6 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.5 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.4 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 0.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.2 5.1 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 4.7 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.3 4.3 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 3.5 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 2.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 2.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 2.5 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 2.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.1 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.9 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.7 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.7 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases