Motif ID: CLOCK

Z-value: 1.045


Transcription factors associated with CLOCK:

Gene SymbolEntrez IDGene Name
CLOCK ENSG00000134852.10 CLOCK



Activity profile for motif CLOCK.

activity profile for motif CLOCK


Sorted Z-values histogram for motif CLOCK

Sorted Z-values for motif CLOCK



Network of associatons between targets according to the STRING database.



First level regulatory network of CLOCK

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_125366089 2.749 ENST00000366139.3
ENST00000278919.3
 FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr12_-_25102252 2.647 ENST00000261192.7
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr17_+_62223320 2.522 ENST00000580828.1
ENST00000582965.1
 SNORA76

small nucleolar RNA, H/ACA box 76

chr5_+_135394840 2.465 ENST00000503087.1
 TGFBI
transforming growth factor, beta-induced, 68kDa
chr2_-_216257849 2.454 ENST00000456923.1
 FN1
fibronectin 1
chr1_+_120839412 2.442 ENST00000355228.4
 FAM72B
family with sequence similarity 72, member B
chr1_-_113498616 2.334 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
 SLC16A1


solute carrier family 16 (monocarboxylate transporter), member 1


chr6_+_151561506 2.274 ENST00000253332.1
 AKAP12
A kinase (PRKA) anchor protein 12
chr18_+_33877654 2.210 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
 FHOD3



formin homology 2 domain containing 3



chr11_-_66725837 2.184 ENST00000393958.2
ENST00000393960.1
ENST00000524491.1
ENST00000355677.3
 PC



pyruvate carboxylase



chr11_+_72929319 2.068 ENST00000393597.2
ENST00000311131.2
 P2RY2

purinergic receptor P2Y, G-protein coupled, 2

chr11_+_72929402 2.049 ENST00000393596.2
 P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr1_-_26232951 2.042 ENST00000426559.2
ENST00000455785.2
 STMN1

stathmin 1

chr16_-_4588762 2.028 ENST00000562334.1
ENST00000562579.1
ENST00000567695.1
ENST00000563507.1
 CDIP1



cell death-inducing p53 target 1



chr2_-_31361543 1.976 ENST00000349752.5
 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr20_+_44441215 1.965 ENST00000356455.4
ENST00000405520.1
 UBE2C

ubiquitin-conjugating enzyme E2C

chr20_+_44441304 1.961 ENST00000352551.5
 UBE2C
ubiquitin-conjugating enzyme E2C
chr16_-_4588822 1.947 ENST00000564828.1
 CDIP1
cell death-inducing p53 target 1
chr9_-_123639304 1.892 ENST00000436309.1
 PHF19
PHD finger protein 19
chr4_-_103266355 1.885 ENST00000424970.2
 SLC39A8
solute carrier family 39 (zinc transporter), member 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 216 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.4 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.4 5.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 5.1 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.7 4.4 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.4 4.3 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.3 4.1 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.5 3.3 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.3 3.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.6 3.0 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.5 2.9 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.3 2.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.2 2.7 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 2.7 GO:0006338 chromatin remodeling(GO:0006338)
0.8 2.5 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.8 2.3 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 2.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.7 2.2 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1 2.2 GO:0051639 actin filament network formation(GO:0051639)
0.3 2.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.7 2.0 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.7 5.2 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.0 3.5 GO:0032587 ruffle membrane(GO:0032587)
0.4 3.3 GO:0070552 BRISC complex(GO:0070552)
0.1 3.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 2.8 GO:0034709 methylosome(GO:0034709)
0.0 2.8 GO:0001650 fibrillar center(GO:0001650)
0.0 2.6 GO:0005604 basement membrane(GO:0005604)
0.2 2.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 2.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 2.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 2.3 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 2.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 2.0 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 1.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.4 1.5 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 1.3 GO:0070545 PeBoW complex(GO:0070545)
0.1 1.3 GO:0045120 pronucleus(GO:0045120)
0.1 1.3 GO:0005642 annulate lamellae(GO:0005642)
0.3 1.2 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 5.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 4.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.7 4.4 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 4.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.5 3.3 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 3.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 2.8 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 2.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 2.7 GO:0016504 peptidase activator activity(GO:0016504)
0.0 2.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 2.4 GO:0035064 methylated histone binding(GO:0035064)
0.8 2.3 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 2.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 2.2 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.2 2.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.1 2.1 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 2.0 GO:0004985 opioid receptor activity(GO:0004985)
0.0 2.0 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 6.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 5.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.4 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.3 ST_STAT3_PATHWAY STAT3 Pathway
0.0 1.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.1 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_BARD1_PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.2 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.2 4.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 4.2 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 4.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 3.3 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 3.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.8 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.1 2.7 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 2.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 2.1 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 2.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 2.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.7 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.4 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation