Motif ID: CREB1

Z-value: 1.032


Transcription factors associated with CREB1:

Gene SymbolEntrez IDGene Name
CREB1 ENSG00000118260.10 CREB1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CREB1hg19_v2_chr2_+_208394794_2083948340.272.0e-01Click!


Activity profile for motif CREB1.

activity profile for motif CREB1


Sorted Z-values histogram for motif CREB1

Sorted Z-values for motif CREB1



Network of associatons between targets according to the STRING database.



First level regulatory network of CREB1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_132628963 2.384 ENST00000330579.1
NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr11_+_126139005 1.953 ENST00000263578.5
ENST00000442061.2
ENST00000532125.1
FOXRED1


FAD-dependent oxidoreductase domain containing 1


chr5_+_72861560 1.496 ENST00000296792.4
ENST00000509005.1
ENST00000543251.1
ENST00000508686.1
ENST00000508491.1
UTP15




UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)




chr3_-_52443799 1.360 ENST00000470173.1
ENST00000296288.5
BAP1

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

chr6_+_41888926 1.341 ENST00000230340.4
BYSL
bystin-like
chr16_+_19079215 1.296 ENST00000544894.2
ENST00000561858.1
COQ7

coenzyme Q7 homolog, ubiquinone (yeast)

chr16_+_19078960 1.277 ENST00000568985.1
ENST00000566110.1
COQ7

coenzyme Q7 homolog, ubiquinone (yeast)

chr4_-_54232144 1.274 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
SCFD2


sec1 family domain containing 2


chr10_-_113943447 1.173 ENST00000369425.1
ENST00000348367.4
ENST00000423155.1
GPAM


glycerol-3-phosphate acyltransferase, mitochondrial


chr16_+_19079311 1.167 ENST00000569127.1
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr12_-_132628847 1.079 ENST00000397333.3
DDX51
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr2_+_114195268 1.066 ENST00000259199.4
ENST00000416503.2
ENST00000433343.2
CBWD2


COBW domain containing 2


chr8_+_92082424 1.054 ENST00000285420.4
ENST00000404789.3
OTUD6B

OTU domain containing 6B

chr11_+_60609537 1.041 ENST00000227520.5
CCDC86
coiled-coil domain containing 86
chr2_-_242626127 0.976 ENST00000445261.1
DTYMK
deoxythymidylate kinase (thymidylate kinase)
chr11_-_66112555 0.910 ENST00000425825.2
ENST00000359957.3
BRMS1

breast cancer metastasis suppressor 1

chr19_+_58341656 0.907 ENST00000442832.4
ENST00000594901.1
ZNF587B

zinc finger protein 587B

chr11_-_126138808 0.896 ENST00000332118.6
ENST00000532259.1
SRPR

signal recognition particle receptor (docking protein)

chr16_+_70380732 0.869 ENST00000302243.7
DDX19A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
chrX_+_24711997 0.866 ENST00000379068.3
ENST00000379059.3
POLA1

polymerase (DNA directed), alpha 1, catalytic subunit


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 2.9 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 2.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 2.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 2.2 GO:0006400 tRNA modification(GO:0006400)
0.3 1.9 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.2 1.9 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 1.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 1.6 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 1.6 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.1 1.5 GO:0007000 nucleolus organization(GO:0007000)
0.0 1.5 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.3 1.4 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 1.3 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 1.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 1.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.1 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 1.1 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 1.1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.4 2.5 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.8 2.4 GO:0030689 Noc complex(GO:0030689)
0.0 2.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.9 GO:0015030 Cajal body(GO:0015030)
0.0 1.8 GO:0016592 mediator complex(GO:0016592)
0.0 1.6 GO:0005643 nuclear pore(GO:0005643)
0.1 1.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 1.4 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.3 1.0 GO:0005846 nuclear cap binding complex(GO:0005846)
0.1 1.0 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 1.0 GO:0070822 Sin3-type complex(GO:0070822)
0.0 1.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.9 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.9 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.9 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0004497 monooxygenase activity(GO:0004497)
0.0 2.6 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.8 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.1 1.5 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 1.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 1.3 GO:0008308 voltage-gated anion channel activity(GO:0008308)
0.4 1.2 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.3 1.2 GO:0016429 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.2 1.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.1 1.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 1.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 1.0 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 1.0 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 1.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.0 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 0.9 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.5 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 1.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.3 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.2 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.0 1.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.1 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.0 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 1.0 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 0.9 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 0.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.8 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.7 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA