Motif ID: CREB3L1_CREB3

Z-value: 0.624

Transcription factors associated with CREB3L1_CREB3:

Gene SymbolEntrez IDGene Name
CREB3 ENSG00000107175.6 CREB3
CREB3L1 ENSG00000157613.6 CREB3L1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CREB3hg19_v2_chr9_+_35732312_35732332-0.386.9e-02Click!
CREB3L1hg19_v2_chr11_+_46299199_46299233-0.262.2e-01Click!


Activity profile for motif CREB3L1_CREB3.

activity profile for motif CREB3L1_CREB3


Sorted Z-values histogram for motif CREB3L1_CREB3

Sorted Z-values for motif CREB3L1_CREB3



Network of associatons between targets according to the STRING database.



First level regulatory network of CREB3L1_CREB3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_113498616 1.774 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
 SLC16A1


solute carrier family 16 (monocarboxylate transporter), member 1


chr1_-_113498943 1.739 ENST00000369626.3
 SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr4_+_75311019 1.498 ENST00000502307.1
 AREG
amphiregulin
chr4_+_75310851 1.406 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr12_+_41086297 1.229 ENST00000551295.2
 CNTN1
contactin 1
chr9_+_124461603 1.205 ENST00000373782.3
 DAB2IP
DAB2 interacting protein
chr6_+_151561085 1.074 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chr11_-_64646086 1.035 ENST00000320631.3
 EHD1
EH-domain containing 1
chr4_-_122744998 0.964 ENST00000274026.5
 CCNA2
cyclin A2
chr11_+_125495862 0.886 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
 CHEK1




checkpoint kinase 1




chr19_+_38810447 0.878 ENST00000263372.3
 KCNK6
potassium channel, subfamily K, member 6
chr22_+_38864041 0.827 ENST00000216014.4
ENST00000409006.3
 KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr5_+_94890840 0.817 ENST00000504763.1
 ARSK
arylsulfatase family, member K
chr3_-_156272924 0.817 ENST00000467789.1
ENST00000265044.2
 SSR3

signal sequence receptor, gamma (translocon-associated protein gamma)

chr14_+_68086515 0.758 ENST00000261783.3
 ARG2
arginase 2
chr3_+_100211412 0.755 ENST00000323523.4
ENST00000403410.1
ENST00000449609.1
 TMEM45A


transmembrane protein 45A


chr1_+_45205478 0.754 ENST00000452259.1
ENST00000372224.4
 KIF2C

kinesin family member 2C

chr1_+_45205498 0.747 ENST00000372218.4
 KIF2C
kinesin family member 2C
chr19_+_41256764 0.705 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
 SNRPA



small nuclear ribonucleoprotein polypeptide A



chr7_+_116593953 0.684 ENST00000397750.3
 ST7-OT4
ST7 overlapping transcript 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.5 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.4 2.9 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 2.3 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.2 1.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 1.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 1.3 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.2 1.2 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 1.2 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.2 1.1 GO:0044565 dendritic cell proliferation(GO:0044565)
0.2 1.1 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.1 1.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.3 1.0 GO:0071314 cellular response to cocaine(GO:0071314)
0.1 1.0 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 1.0 GO:0006621 protein retention in ER lumen(GO:0006621)
0.2 0.9 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.9 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.1 0.8 GO:0000050 urea cycle(GO:0000050)
0.0 0.8 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 0.7 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 0.7 GO:0007135 meiosis II(GO:0007135)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.4 1.2 GO:1990032 parallel fiber(GO:1990032)
0.1 1.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 1.0 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.2 1.0 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.7 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.6 GO:0055087 Ski complex(GO:0055087)
0.0 0.5 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.1 0.4 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
0.1 0.4 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.4 GO:0032010 phagolysosome(GO:0032010)
0.0 0.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.3 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.3 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.5 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 3.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 1.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 1.5 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.2 1.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.2 1.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 1.2 GO:0017166 vinculin binding(GO:0017166)
0.1 1.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.0 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 1.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.2 0.9 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.8 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.7 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.5 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.5 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 2.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.1 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.5 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.1 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 1.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 0.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.5 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport