Motif ID: CREB3L2

Z-value: 0.490


Transcription factors associated with CREB3L2:

Gene SymbolEntrez IDGene Name
CREB3L2 ENSG00000182158.10 CREB3L2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CREB3L2hg19_v2_chr7_-_137686791_1376868210.038.9e-01Click!


Activity profile for motif CREB3L2.

activity profile for motif CREB3L2


Sorted Z-values histogram for motif CREB3L2

Sorted Z-values for motif CREB3L2



Network of associatons between targets according to the STRING database.



First level regulatory network of CREB3L2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_151561506 1.597 ENST00000253332.1
 AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_113498616 1.587 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
 SLC16A1


solute carrier family 16 (monocarboxylate transporter), member 1


chr1_-_113498943 1.242 ENST00000369626.3
 SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr6_+_151561085 1.123 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chrX_+_55246818 0.912 ENST00000374952.1
 PAGE5
P antigen family, member 5 (prostate associated)
chr19_-_11688500 0.852 ENST00000433365.2
 ACP5
acid phosphatase 5, tartrate resistant
chr18_-_46987000 0.671 ENST00000442713.2
ENST00000269445.6
 DYM

dymeclin

chr18_+_56530794 0.665 ENST00000590285.1
ENST00000586085.1
ENST00000589288.1
 ZNF532


zinc finger protein 532


chr12_-_48152853 0.612 ENST00000171000.4
 RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr20_+_25228669 0.595 ENST00000216962.4
 PYGB
phosphorylase, glycogen; brain
chr12_-_48152611 0.595 ENST00000389212.3
 RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr17_+_39969183 0.575 ENST00000321562.4
 FKBP10
FK506 binding protein 10, 65 kDa
chr9_+_124461603 0.543 ENST00000373782.3
 DAB2IP
DAB2 interacting protein
chr6_-_144329531 0.536 ENST00000429150.1
ENST00000392309.1
ENST00000416623.1
ENST00000392307.1
 PLAGL1



pleiomorphic adenoma gene-like 1



chr12_-_48152428 0.528 ENST00000449771.2
ENST00000395358.3
 RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr2_-_27341765 0.477 ENST00000405600.1
 CGREF1
cell growth regulator with EF-hand domain 1
chr2_-_27341966 0.461 ENST00000402394.1
ENST00000402550.1
ENST00000260595.5
 CGREF1


cell growth regulator with EF-hand domain 1


chr7_+_2671568 0.450 ENST00000258796.7
 TTYH3
tweety family member 3
chr19_-_4670345 0.449 ENST00000599630.1
ENST00000262947.3
 C19orf10

chromosome 19 open reading frame 10

chrX_+_55246771 0.408 ENST00000289619.5
ENST00000374955.3
 PAGE5

P antigen family, member 5 (prostate associated)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.8 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.2 2.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.4 1.7 GO:0033123 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.2 1.1 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.2 0.9 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 0.6 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.2 0.6 GO:0035623 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.2 0.6 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 0.5 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.5 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.5 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.5 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.5 GO:0042339 keratan sulfate biosynthetic process(GO:0018146) keratan sulfate metabolic process(GO:0042339)
0.1 0.4 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.4 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.4 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 0.5 GO:1990032 parallel fiber(GO:1990032)
0.1 0.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.2 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0000801 central element(GO:0000801)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.2 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.8 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.2 2.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 1.1 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.9 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.6 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.2 0.5 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.5 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.4 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.3 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.1 PID_S1P_S1P2_PATHWAY S1P2 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.5 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.0 REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.0 0.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha