Motif ID: CREB5_CREM_JUNB

Z-value: 0.621

Transcription factors associated with CREB5_CREM_JUNB:

Gene SymbolEntrez IDGene Name
CREB5 ENSG00000146592.12 CREB5
CREM ENSG00000095794.15 CREM
JUNB ENSG00000171223.4 JUNB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CREMhg19_v2_chr10_+_35415851_35415941-0.377.5e-02Click!
JUNBhg19_v2_chr19_+_12902289_129023100.272.0e-01Click!
CREB5hg19_v2_chr7_+_28725585_28725608-0.125.6e-01Click!


Activity profile for motif CREB5_CREM_JUNB.

activity profile for motif CREB5_CREM_JUNB


Sorted Z-values histogram for motif CREB5_CREM_JUNB

Sorted Z-values for motif CREB5_CREM_JUNB



Network of associatons between targets according to the STRING database.



First level regulatory network of CREB5_CREM_JUNB

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_216300784 4.429 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr4_+_75310851 2.811 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr4_+_75311019 2.734 ENST00000502307.1
 AREG
amphiregulin
chr21_-_44846999 1.956 ENST00000270162.6
 SIK1
salt-inducible kinase 1
chr4_+_75480629 1.956 ENST00000380846.3
 AREGB
amphiregulin B
chr20_+_58179582 1.874 ENST00000371015.1
ENST00000395639.4
 PHACTR3

phosphatase and actin regulator 3

chr2_+_70142232 1.841 ENST00000540449.1
 MXD1
MAX dimerization protein 1
chr8_-_10697281 1.801 ENST00000553390.1
ENST00000524114.1
ENST00000554914.1
 SOX7
PINX1
SOX7
SRY (sex determining region Y)-box 7
PIN2/TERF1 interacting, telomerase inhibitor 1
Transcription factor SOX-7; Uncharacterized protein; cDNA FLJ58508, highly similar to Transcription factor SOX-7
chr7_+_5632436 1.781 ENST00000340250.6
ENST00000382361.3
 FSCN1

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

chr14_+_68086515 1.638 ENST00000261783.3
 ARG2
arginase 2
chr16_-_4588762 1.312 ENST00000562334.1
ENST00000562579.1
ENST00000567695.1
ENST00000563507.1
 CDIP1



cell death-inducing p53 target 1



chr16_-_4588822 1.190 ENST00000564828.1
 CDIP1
cell death-inducing p53 target 1
chr20_-_56284816 1.183 ENST00000395819.3
ENST00000341744.3
 PMEPA1

prostate transmembrane protein, androgen induced 1

chr2_+_37571717 1.156 ENST00000338415.3
ENST00000404976.1
 QPCT

glutaminyl-peptide cyclotransferase

chr20_-_44420507 1.146 ENST00000243938.4
 WFDC3
WAP four-disulfide core domain 3
chr19_+_16187085 1.136 ENST00000300933.4
 TPM4
tropomyosin 4
chr2_+_37571845 1.114 ENST00000537448.1
 QPCT
glutaminyl-peptide cyclotransferase
chr2_-_220408430 1.108 ENST00000243776.6
 CHPF
chondroitin polymerizing factor
chr17_-_7155274 1.085 ENST00000318988.6
ENST00000575783.1
ENST00000573600.1
 CTDNEP1


CTD nuclear envelope phosphatase 1


chr9_+_34989638 1.040 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
 DNAJB5


DnaJ (Hsp40) homolog, subfamily B, member 5



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 204 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.5 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
1.8 5.4 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.8 2.3 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.5 2.3 GO:1904744 positive regulation of telomeric DNA binding(GO:1904744)
0.4 2.0 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.2 1.9 GO:0002329 pre-B cell differentiation(GO:0002329)
0.3 1.8 GO:0030035 microspike assembly(GO:0030035)
0.0 1.8 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.3 1.7 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 1.6 GO:0000050 urea cycle(GO:0000050)
0.0 1.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.2 1.5 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 1.5 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.4 GO:0031639 plasminogen activation(GO:0031639)
0.1 1.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 1.3 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.3 1.2 GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0 1.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 1.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.2 1.0 GO:0099590 neurotransmitter receptor internalization(GO:0099590)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.4 5.4 GO:0005577 fibrinogen complex(GO:0005577)
0.4 3.5 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.0 2.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 2.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 2.1 GO:0016363 nuclear matrix(GO:0016363)
0.4 1.8 GO:0044393 microspike(GO:0044393)
0.0 1.8 GO:0001533 cornified envelope(GO:0001533)
0.1 1.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 1.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.3 1.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 1.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 1.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.2 GO:0030673 axolemma(GO:0030673)
0.0 1.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 0.7 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.2 0.7 GO:0033150 cytoskeletal calyx(GO:0033150)
0.1 0.7 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 0.7 GO:0035976 AP1 complex(GO:0035976)
0.1 0.6 GO:0032437 cuticular plate(GO:0032437)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 5.4 GO:0016504 peptidase activator activity(GO:0016504)
0.0 3.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.8 2.3 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 2.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 2.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 2.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.1 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.9 GO:0008144 drug binding(GO:0008144)
0.1 1.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.6 GO:0051219 phosphoprotein binding(GO:0051219)
0.3 1.5 GO:0050436 microfibril binding(GO:0050436)
0.1 1.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.3 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.0 1.3 GO:0043022 ribosome binding(GO:0043022)
0.0 1.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 1.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 5.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 5.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 3.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 1.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.0 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.6 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 2.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.2 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.1 2.0 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 1.7 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.2 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.1 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.9 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.7 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels