Motif ID: CUX1

Z-value: 0.963


Transcription factors associated with CUX1:

Gene SymbolEntrez IDGene Name
CUX1 ENSG00000257923.5 CUX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CUX1hg19_v2_chr7_+_101917407_101917445-0.405.0e-02Click!


Activity profile for motif CUX1.

activity profile for motif CUX1


Sorted Z-values histogram for motif CUX1

Sorted Z-values for motif CUX1



Network of associatons between targets according to the STRING database.



First level regulatory network of CUX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_157318477 6.798 ENST00000444154.1
 AC006372.1
AC006372.1
chr8_-_91095099 2.558 ENST00000265431.3
 CALB1
calbindin 1, 28kDa
chr19_-_51472222 2.325 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr19_-_51472031 2.184 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr5_+_147691979 1.988 ENST00000274565.4
 SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr2_-_219696519 1.953 ENST00000545803.1
ENST00000430489.1
ENST00000392098.3
 PRKAG3


protein kinase, AMP-activated, gamma 3 non-catalytic subunit


chr2_-_31637560 1.914 ENST00000379416.3
 XDH
xanthine dehydrogenase
chr2_-_113594279 1.784 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B


interleukin 1, beta


chr22_+_31488433 1.771 ENST00000455608.1
 SMTN
smoothelin
chr9_+_33795533 1.589 ENST00000379405.3
 PRSS3
protease, serine, 3
chr19_+_35645817 1.486 ENST00000423817.3
 FXYD5
FXYD domain containing ion transport regulator 5
chr11_-_123065989 1.296 ENST00000448775.2
 CLMP
CXADR-like membrane protein
chr17_+_7942424 1.279 ENST00000573359.1
 ALOX15B
arachidonate 15-lipoxygenase, type B
chr11_-_66675371 1.255 ENST00000393955.2
 PC
pyruvate carboxylase
chr17_+_7942335 1.226 ENST00000380183.4
ENST00000572022.1
ENST00000380173.2
 ALOX15B


arachidonate 15-lipoxygenase, type B


chr19_-_55658281 1.181 ENST00000585321.2
ENST00000587465.2
 TNNT1

troponin T type 1 (skeletal, slow)

chr6_+_86159821 1.144 ENST00000369651.3
 NT5E
5'-nucleotidase, ecto (CD73)
chr19_-_55658687 1.095 ENST00000593046.1
 TNNT1
troponin T type 1 (skeletal, slow)
chr12_-_52845910 1.073 ENST00000252252.3
 KRT6B
keratin 6B
chr1_+_17531614 1.017 ENST00000375471.4
 PADI1
peptidyl arginine deiminase, type I

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 208 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 GO:0016540 protein autoprocessing(GO:0016540)
0.3 3.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.3 2.7 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.3 2.6 GO:0072025 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
0.4 2.5 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 2.4 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.8 2.3 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.6 2.3 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.1 2.3 GO:0009235 cobalamin metabolic process(GO:0009235)
0.6 1.9 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.5 1.9 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 1.9 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.6 1.8 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 1.5 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0 1.5 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 1.4 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 1.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.4 1.3 GO:0043317 regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318)
0.0 1.3 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 1.2 GO:0015816 glycine transport(GO:0015816)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0005861 troponin complex(GO:0005861)
0.0 2.6 GO:0043195 terminal bouton(GO:0043195)
0.0 2.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.0 1.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.3 1.6 GO:0031262 Ndc80 complex(GO:0031262)
0.0 1.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.4 GO:0045095 keratin filament(GO:0045095)
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.0 1.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.9 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.7 GO:0097209 epidermal lamellar body(GO:0097209)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 2.9 GO:0031014 troponin T binding(GO:0031014)
0.5 2.6 GO:0005499 vitamin D binding(GO:0005499)
0.8 2.5 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.1 2.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 2.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 2.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 2.1 GO:0051015 actin filament binding(GO:0051015)
0.2 1.9 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.2 1.9 GO:0009374 biotin binding(GO:0009374)
0.0 1.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 1.8 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 1.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.6 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 1.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.1 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 2.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.1 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.3 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.2 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 1.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.8 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.6 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.5 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 2.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.4 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 2.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.6 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.3 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 1.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.9 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.8 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.0 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.6 REACTOME_LIPOPROTEIN_METABOLISM Genes involved in Lipoprotein metabolism