Motif ID: DDIT3

Z-value: 0.288


Transcription factors associated with DDIT3:

Gene SymbolEntrez IDGene Name
DDIT3 ENSG00000175197.6 DDIT3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v2_chr12_-_57914275_579143040.424.0e-02Click!


Activity profile for motif DDIT3.

activity profile for motif DDIT3


Sorted Z-values histogram for motif DDIT3

Sorted Z-values for motif DDIT3



Network of associatons between targets according to the STRING database.



First level regulatory network of DDIT3

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_25102252 0.761 ENST00000261192.7
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_25101920 0.592 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr19_-_35992780 0.553 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
 DMKN


dermokine


chr9_+_80912059 0.459 ENST00000347159.2
ENST00000376588.3
 PSAT1

phosphoserine aminotransferase 1

chr15_+_41245160 0.386 ENST00000444189.2
ENST00000446533.3
 CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr14_+_21387508 0.375 ENST00000555624.1
 RP11-84C10.2
RP11-84C10.2
chr2_-_216300784 0.347 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr1_+_150954493 0.345 ENST00000368947.4
 ANXA9
annexin A9
chr2_-_208030647 0.328 ENST00000309446.6
 KLF7
Kruppel-like factor 7 (ubiquitous)
chr12_-_52867569 0.302 ENST00000252250.6
 KRT6C
keratin 6C
chr2_-_40680578 0.286 ENST00000455476.1
 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr12_-_53074182 0.207 ENST00000252244.3
 KRT1
keratin 1
chr22_-_27456361 0.194 ENST00000453934.1
 CTA-992D9.6
CTA-992D9.6
chr7_-_56101826 0.187 ENST00000421626.1
 PSPH
phosphoserine phosphatase
chr6_+_151187074 0.186 ENST00000367308.4
 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr1_-_67519782 0.182 ENST00000235345.5
 SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr10_-_17659234 0.173 ENST00000466335.1
 PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr10_-_17659357 0.158 ENST00000326961.6
ENST00000361271.3
 PTPLA

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

chr11_+_62495997 0.157 ENST00000316461.4
 TTC9C
tetratricopeptide repeat domain 9C
chr17_-_47925379 0.140 ENST00000352793.2
ENST00000334568.4
ENST00000398154.1
ENST00000436235.1
ENST00000326219.5
 TAC4




tachykinin 4 (hemokinin)





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.6 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.5 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.0 0.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.3 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 0.3 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 0.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 0.2 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.2 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.2 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.1 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)

Gene overrepresentation in cellular_component category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.5 GO:0008483 transaminase activity(GO:0008483)
0.1 0.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.3 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.1 0.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.2 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins