Motif ID: DLX1_HOXA3_BARX2

Z-value: 1.246

Transcription factors associated with DLX1_HOXA3_BARX2:

Gene SymbolEntrez IDGene Name
BARX2 ENSG00000043039.5 BARX2
DLX1 ENSG00000144355.10 DLX1
HOXA3 ENSG00000105997.18 HOXA3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BARX2hg19_v2_chr11_+_129245796_129245835-0.866.0e-08Click!
DLX1hg19_v2_chr2_+_172950227_172950264-0.655.4e-04Click!


Activity profile for motif DLX1_HOXA3_BARX2.

activity profile for motif DLX1_HOXA3_BARX2


Sorted Z-values histogram for motif DLX1_HOXA3_BARX2

Sorted Z-values for motif DLX1_HOXA3_BARX2



Network of associatons between targets according to the STRING database.



First level regulatory network of DLX1_HOXA3_BARX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_228736335 17.593 ENST00000440997.1
ENST00000545118.1
 DAW1

dynein assembly factor with WDR repeat domains 1

chr11_+_101918153 15.555 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
 C11orf70


chromosome 11 open reading frame 70


chr2_+_228736321 13.914 ENST00000309931.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr12_+_7013897 10.484 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr12_+_7014064 10.422 ENST00000443597.2
 LRRC23
leucine rich repeat containing 23
chr13_+_36050881 6.849 ENST00000537702.1
 NBEA
neurobeachin
chr11_-_26593779 6.829 ENST00000529533.1
 MUC15
mucin 15, cell surface associated
chr12_+_7014126 6.628 ENST00000415834.1
ENST00000436789.1
 LRRC23

leucine rich repeat containing 23

chr11_-_63376013 5.748 ENST00000540943.1
 PLA2G16
phospholipase A2, group XVI
chr11_-_26593649 5.176 ENST00000455601.2
 MUC15
mucin 15, cell surface associated
chr11_-_26593677 5.088 ENST00000527569.1
 MUC15
mucin 15, cell surface associated
chr16_-_28634874 4.825 ENST00000395609.1
ENST00000350842.4
 SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr4_-_70518941 4.488 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
 UGT2A1

UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr12_-_25348007 3.892 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1






cancer susceptibility candidate 1






chr2_+_228735763 3.862 ENST00000373666.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr6_-_32908792 3.712 ENST00000418107.2
 HLA-DMB
major histocompatibility complex, class II, DM beta
chr2_+_26624775 3.615 ENST00000288710.2
 DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr12_+_20963632 3.592 ENST00000540853.1
ENST00000261196.2
 SLCO1B3

solute carrier organic anion transporter family, member 1B3

chr4_+_70861647 3.537 ENST00000246895.4
ENST00000381060.2
 STATH

statherin

chr6_-_28411241 3.205 ENST00000289788.4
 ZSCAN23
zinc finger and SCAN domain containing 23

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 194 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 37.5 GO:0007368 determination of left/right symmetry(GO:0007368)
0.2 15.1 GO:0016266 O-glycan processing(GO:0016266)
0.6 12.8 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 8.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 5.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.6 5.7 GO:0046485 ether lipid metabolic process(GO:0046485)
1.6 4.9 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.2 4.9 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.5 4.8 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
1.6 4.7 GO:0010430 fatty acid omega-oxidation(GO:0010430)
1.5 4.5 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.2 4.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.3 3.5 GO:0046541 saliva secretion(GO:0046541)
0.5 3.3 GO:0071461 cellular response to redox state(GO:0071461)
0.2 2.6 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 2.4 GO:0002456 T cell mediated immunity(GO:0002456)
0.1 2.1 GO:0000042 protein targeting to Golgi(GO:0000042)
0.5 2.0 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.1 2.0 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 2.0 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 35.2 GO:0005929 cilium(GO:0005929)
0.1 17.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 8.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 6.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 4.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 4.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 3.4 GO:0001650 fibrillar center(GO:0001650)
0.1 2.6 GO:0000145 exocyst(GO:0000145)
0.0 2.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 1.8 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.5 GO:0071004 U2-type prespliceosome(GO:0071004)
0.3 1.4 GO:0060187 cell pole(GO:0060187)
0.2 1.4 GO:0036021 endolysosome lumen(GO:0036021)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.2 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 1.2 GO:0042101 T cell receptor complex(GO:0042101)
0.2 1.1 GO:0002177 manchette(GO:0002177)
0.1 1.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
1.1 5.7 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.2 5.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 5.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 5.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 4.9 GO:0023026 MHC class II protein complex binding(GO:0023026)
1.2 4.8 GO:0019770 IgG receptor activity(GO:0019770)
1.1 4.5 GO:0061714 folic acid receptor activity(GO:0061714)
1.0 4.0 GO:0004031 aldehyde oxidase activity(GO:0004031)
1.2 3.5 GO:0046848 hydroxyapatite binding(GO:0046848)
0.3 3.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 3.2 GO:0004386 helicase activity(GO:0004386)
0.1 2.9 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 2.9 GO:0005178 integrin binding(GO:0005178)
0.1 2.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 2.3 GO:0005179 hormone activity(GO:0005179)
0.5 2.0 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.1 1.8 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 1.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 1.7 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.1 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 2.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.2 PID_INSULIN_PATHWAY Insulin Pathway
0.0 1.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.5 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 17.0 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.4 12.8 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.4 5.8 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.3 5.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.2 5.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.3 4.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 3.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 2.9 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.1 2.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.2 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 2.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.3 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 1.2 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.2 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 1.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.8 REACTOME_PHASE_II_CONJUGATION Genes involved in Phase II conjugation