Motif ID: DLX3_EVX1_MEOX1

Z-value: 0.513

Transcription factors associated with DLX3_EVX1_MEOX1:

Gene SymbolEntrez IDGene Name
DLX3 ENSG00000064195.7 DLX3
EVX1 ENSG00000106038.8 EVX1
MEOX1 ENSG00000005102.8 MEOX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EVX1hg19_v2_chr7_+_27282319_272823940.262.3e-01Click!
MEOX1hg19_v2_chr17_-_41738931_41739040,
hg19_v2_chr17_-_41739283_41739322		0.232.9e-01Click!
DLX3hg19_v2_chr17_-_48072574_480725970.077.4e-01Click!


Activity profile for motif DLX3_EVX1_MEOX1.

activity profile for motif DLX3_EVX1_MEOX1


Sorted Z-values histogram for motif DLX3_EVX1_MEOX1

Sorted Z-values for motif DLX3_EVX1_MEOX1



Network of associatons between targets according to the STRING database.



First level regulatory network of DLX3_EVX1_MEOX1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_111718173 1.325 ENST00000494932.1
 TAGLN3
transgelin 3
chr6_+_151646800 1.298 ENST00000354675.6
 AKAP12
A kinase (PRKA) anchor protein 12
chr4_+_169013666 1.061 ENST00000359299.3
 ANXA10
annexin A10
chr3_+_111717600 0.835 ENST00000273368.4
 TAGLN3
transgelin 3
chr3_+_111718036 0.815 ENST00000455401.2
 TAGLN3
transgelin 3
chr3_+_111717511 0.792 ENST00000478951.1
ENST00000393917.2
 TAGLN3

transgelin 3

chr8_-_10512569 0.583 ENST00000382483.3
 RP1L1
retinitis pigmentosa 1-like 1
chr6_+_130339710 0.533 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr12_-_89746173 0.528 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr10_+_118187379 0.477 ENST00000369230.3
 PNLIPRP3
pancreatic lipase-related protein 3
chr3_-_141747950 0.449 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_+_107712173 0.401 ENST00000280758.5
ENST00000420571.2
 BTBD11

BTB (POZ) domain containing 11

chr14_-_37051798 0.394 ENST00000258829.5
 NKX2-8
NK2 homeobox 8
chr13_-_46716969 0.385 ENST00000435666.2
 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr8_+_22424551 0.373 ENST00000523348.1
 SORBS3
sorbin and SH3 domain containing 3
chr15_-_64673630 0.365 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
 KIAA0101


KIAA0101


chr20_+_60174827 0.347 ENST00000543233.1
 CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr18_-_44181442 0.347 ENST00000398722.4
 LOXHD1
lipoxygenase homology domains 1
chr17_-_57229155 0.340 ENST00000584089.1
 SKA2
spindle and kinetochore associated complex subunit 2
chr12_+_15699286 0.332 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
 PTPRO



protein tyrosine phosphatase, receptor type, O




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.8 GO:0042461 photoreceptor cell development(GO:0042461)
0.2 0.5 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.3 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.3 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.3 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.2 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.2 GO:0035627 ceramide transport(GO:0035627)
0.0 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.2 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0043209 myelin sheath(GO:0043209)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.2 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.1 GO:0036025 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0051015 actin filament binding(GO:0051015)
0.1 1.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.4 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.4 GO:0000150 recombinase activity(GO:0000150)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.2 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0 0.2 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection