Motif ID: DLX5

Z-value: 0.785


Transcription factors associated with DLX5:

Gene SymbolEntrez IDGene Name
DLX5 ENSG00000105880.4 DLX5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DLX5hg19_v2_chr7_-_96654133_966544090.184.1e-01Click!


Activity profile for motif DLX5.

activity profile for motif DLX5


Sorted Z-values histogram for motif DLX5

Sorted Z-values for motif DLX5



Network of associatons between targets according to the STRING database.



First level regulatory network of DLX5

PNG image of the network

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Top targets:


Showing 1 to 20 of 92 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_7013897 4.067 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr12_+_7014064 4.056 ENST00000443597.2
 LRRC23
leucine rich repeat containing 23
chr2_+_228736321 3.606 ENST00000309931.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr13_+_36050881 3.553 ENST00000537702.1
 NBEA
neurobeachin
chr2_+_228735763 3.535 ENST00000373666.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr12_+_7014126 3.073 ENST00000415834.1
ENST00000436789.1
 LRRC23

leucine rich repeat containing 23

chr2_+_228736335 2.871 ENST00000440997.1
ENST00000545118.1
 DAW1

dynein assembly factor with WDR repeat domains 1

chr11_-_26593779 1.949 ENST00000529533.1
 MUC15
mucin 15, cell surface associated
chr16_+_53133070 1.778 ENST00000565832.1
 CHD9
chromodomain helicase DNA binding protein 9
chr5_-_160279207 1.705 ENST00000327245.5
 ATP10B
ATPase, class V, type 10B
chr3_+_186560462 1.422 ENST00000412955.2
 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr3_+_186560476 1.420 ENST00000320741.2
ENST00000444204.2
 ADIPOQ

adiponectin, C1Q and collagen domain containing

chr4_+_77356248 1.413 ENST00000296043.6
 SHROOM3
shroom family member 3
chr12_-_10151773 1.335 ENST00000298527.6
ENST00000348658.4
 CLEC1B

C-type lectin domain family 1, member B

chr11_-_26593649 1.262 ENST00000455601.2
 MUC15
mucin 15, cell surface associated
chr11_-_26593677 1.185 ENST00000527569.1
 MUC15
mucin 15, cell surface associated
chr8_-_10512569 1.148 ENST00000382483.3
 RP1L1
retinitis pigmentosa 1-like 1
chr4_-_105416039 1.120 ENST00000394767.2
 CXXC4
CXXC finger protein 4
chr5_-_42811986 1.087 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
 SEPP1


selenoprotein P, plasma, 1


chr5_-_20575959 1.083 ENST00000507958.1
 CDH18
cadherin 18, type 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.0 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 4.4 GO:0016266 O-glycan processing(GO:0016266)
0.0 3.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.9 2.8 GO:2000583 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 1.8 GO:0072189 ureter development(GO:0072189)
0.1 1.7 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.5 GO:0061157 mRNA destabilization(GO:0061157)
0.1 1.4 GO:0045176 apical protein localization(GO:0045176)
0.0 1.3 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.0 1.3 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.2 1.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 1.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 1.0 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 0.9 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.9 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.6 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 0.6 GO:0036155 positive regulation of triglyceride catabolic process(GO:0010898) acylglycerol acyl-chain remodeling(GO:0036155)
0.0 0.6 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 0.5 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.1 GO:0005929 cilium(GO:0005929)
0.0 4.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 4.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.0 GO:0005581 collagen trimer(GO:0005581)
0.0 1.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.8 GO:0014802 terminal cisterna(GO:0014802)
0.1 0.5 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)

Gene overrepresentation in molecular_function category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 0.9 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.5 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.3 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 0.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.1 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 2.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere