Motif ID: DMC1

Z-value: 0.471


Transcription factors associated with DMC1:

Gene SymbolEntrez IDGene Name
DMC1 ENSG00000100206.5 DMC1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966172_38966291-0.341.0e-01Click!


Activity profile for motif DMC1.

activity profile for motif DMC1


Sorted Z-values histogram for motif DMC1

Sorted Z-values for motif DMC1



Network of associatons between targets according to the STRING database.



First level regulatory network of DMC1

PNG image of the network

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Top targets:


Showing 1 to 20 of 69 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_94727048 2.291 ENST00000283357.5
 FAM81B
family with sequence similarity 81, member B
chr7_+_6793740 1.761 ENST00000403107.1
ENST00000404077.1
ENST00000435395.1
ENST00000418406.1
 RSPH10B2



radial spoke head 10 homolog B2 (Chlamydomonas)



chr7_-_6010263 1.754 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
 RSPH10B



radial spoke head 10 homolog B (Chlamydomonas)



chr4_+_15471489 1.282 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
 CC2D2A








coiled-coil and C2 domain containing 2A








chr21_-_46348694 1.189 ENST00000355153.4
ENST00000397850.2
 ITGB2

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

chr10_-_62332357 0.666 ENST00000503366.1
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_+_101785727 0.655 ENST00000263468.8
 KIAA1377
KIAA1377
chr2_+_120187465 0.600 ENST00000409826.1
ENST00000417645.1
 TMEM37

transmembrane protein 37

chr10_+_74870206 0.585 ENST00000357321.4
ENST00000349051.5
 NUDT13

nudix (nucleoside diphosphate linked moiety X)-type motif 13

chr11_+_71238313 0.539 ENST00000398536.4
 KRTAP5-7
keratin associated protein 5-7
chr10_+_74870253 0.516 ENST00000544879.1
ENST00000537969.1
ENST00000372997.3
 NUDT13


nudix (nucleoside diphosphate linked moiety X)-type motif 13


chrX_+_105855160 0.509 ENST00000372544.2
ENST00000372548.4
 CXorf57

chromosome X open reading frame 57

chr12_-_9268707 0.464 ENST00000318602.7
 A2M
alpha-2-macroglobulin
chr1_+_166958346 0.438 ENST00000367872.4
 MAEL
maelstrom spermatogenic transposon silencer
chr1_+_166958497 0.380 ENST00000367870.2
 MAEL
maelstrom spermatogenic transposon silencer
chr2_+_233497931 0.358 ENST00000264059.3
 EFHD1
EF-hand domain family, member D1
chr20_+_11008408 0.308 ENST00000378252.1
 C20orf187
chromosome 20 open reading frame 187
chr14_+_74318513 0.306 ENST00000555228.1
ENST00000555661.1
 PTGR2

prostaglandin reductase 2

chr14_+_74318611 0.306 ENST00000555976.1
ENST00000267568.4
 PTGR2

prostaglandin reductase 2

chr2_-_18741882 0.298 ENST00000381249.3
 RDH14
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 1.1 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 1.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.8 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 0.7 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.6 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.3 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.0 GO:0070253 somatostatin secretion(GO:0070253)

Gene overrepresentation in cellular_component category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0036038 MKS complex(GO:0036038)
0.1 1.0 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.3 0.8 GO:0030849 autosome(GO:0030849)
0.0 0.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)

Gene overrepresentation in molecular_function category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.1 0.6 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.2 0.5 GO:0019959 interleukin-8 binding(GO:0019959)
0.1 0.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.4 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.4 PID_CONE_PATHWAY Visual signal transduction: Cones

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway