Motif ID: DRGX_PROP1

Z-value: 0.864

Transcription factors associated with DRGX_PROP1:

Gene SymbolEntrez IDGene Name
DRGX ENSG00000165606.4 DRGX
PROP1 ENSG00000175325.2 PROP1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PROP1hg19_v2_chr5_-_177423243_177423243-0.639.6e-04Click!


Activity profile for motif DRGX_PROP1.

activity profile for motif DRGX_PROP1


Sorted Z-values histogram for motif DRGX_PROP1

Sorted Z-values for motif DRGX_PROP1



Network of associatons between targets according to the STRING database.



First level regulatory network of DRGX_PROP1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_31823792 10.442 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
 BPIFA1


BPI fold containing family A, member 1


chr13_+_50589390 4.484 ENST00000360473.4
ENST00000312942.1
 KCNRG

potassium channel regulator

chr4_-_100356291 3.985 ENST00000476959.1
ENST00000482593.1
 ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr4_-_100356551 3.977 ENST00000209665.4
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr9_-_34397800 3.383 ENST00000297623.2
 C9orf24
chromosome 9 open reading frame 24
chrX_+_35937843 2.881 ENST00000297866.5
 CXorf22
chromosome X open reading frame 22
chr14_+_75536280 2.796 ENST00000238686.8
 ZC2HC1C
zinc finger, C2HC-type containing 1C
chr6_+_88117683 2.473 ENST00000369562.4
 C6ORF165
UPF0704 protein C6orf165
chr5_-_160279207 2.393 ENST00000327245.5
 ATP10B
ATPase, class V, type 10B
chr7_+_90338712 2.316 ENST00000265741.3
ENST00000406263.1
 CDK14

cyclin-dependent kinase 14

chr5_-_137475071 2.188 ENST00000265191.2
 NME5
NME/NM23 family member 5
chr8_-_10512569 2.082 ENST00000382483.3
 RP1L1
retinitis pigmentosa 1-like 1
chr5_-_54468974 2.059 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
 CDC20B




cell division cycle 20B




chr6_-_76072719 1.970 ENST00000370020.1
 FILIP1
filamin A interacting protein 1
chr1_-_92371839 1.920 ENST00000370399.2
 TGFBR3
transforming growth factor, beta receptor III
chr14_+_62584197 1.736 ENST00000334389.4
 LINC00643
long intergenic non-protein coding RNA 643
chr8_-_26724784 1.696 ENST00000380573.3
 ADRA1A
adrenoceptor alpha 1A
chr18_-_52989525 1.629 ENST00000457482.3
 TCF4
transcription factor 4
chr7_+_123241908 1.607 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
 ASB15


ankyrin repeat and SOCS box containing 15


chr11_-_40315640 1.526 ENST00000278198.2
 LRRC4C
leucine rich repeat containing 4C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 10.4 GO:0042710 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
2.7 8.0 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.4 4.7 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 2.5 GO:0010107 potassium ion import(GO:0010107)
0.1 2.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 2.3 GO:0016266 O-glycan processing(GO:0016266)
0.2 2.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 2.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 2.0 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.5 1.9 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 1.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.6 1.7 GO:0001983 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.1 1.7 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 1.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.4 1.5 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.5 1.4 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.5 1.4 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.0 1.4 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.0 1.3 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.4 1.2 GO:0071284 cellular response to lead ion(GO:0071284)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0005796 Golgi lumen(GO:0005796)
0.5 2.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 2.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.2 GO:0005901 caveola(GO:0005901)
0.0 2.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.5 1.9 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 1.6 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.5 GO:0043194 axon initial segment(GO:0043194)
0.1 1.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 1.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 0.9 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.4 GO:0060091 kinocilium(GO:0060091)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 8.0 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 2.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 2.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 2.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 2.3 GO:0030332 cyclin binding(GO:0030332)
0.1 2.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 2.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 1.9 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.6 1.7 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 1.5 GO:0030507 spectrin binding(GO:0030507)
0.5 1.4 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 1.4 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 1.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 1.4 GO:0015248 sterol transporter activity(GO:0015248)
0.4 1.2 GO:0032767 copper-dependent protein binding(GO:0032767)
0.2 1.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.2 1.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 1.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 1.0 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.0 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.9 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.6 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 1.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.7 PID_INSULIN_PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.0 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 3.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 1.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.0 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism