Motif ID: DUXA

Z-value: 1.051


Transcription factors associated with DUXA:

Gene SymbolEntrez IDGene Name
DUXA ENSG00000258873.2 DUXA



Activity profile for motif DUXA.

activity profile for motif DUXA


Sorted Z-values histogram for motif DUXA

Sorted Z-values for motif DUXA



Network of associatons between targets according to the STRING database.



First level regulatory network of DUXA

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51471362 7.709 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr19_-_51471381 7.619 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51472031 5.750 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr4_+_69313145 4.676 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr8_+_7397150 3.922 ENST00000533250.1
 RP11-1118M6.1
proline rich 23 domain containing 1
chr8_-_7638935 3.899 ENST00000528972.1
 AC084121.16
proline rich 23 domain containing 2
chr1_+_152975488 3.800 ENST00000542696.1
 SPRR3
small proline-rich protein 3
chr1_-_153113927 3.776 ENST00000368752.4
 SPRR2B
small proline-rich protein 2B
chr18_+_61445007 3.107 ENST00000447428.1
ENST00000546027.1
 SERPINB7

serpin peptidase inhibitor, clade B (ovalbumin), member 7

chr1_+_17575584 2.720 ENST00000375460.3
 PADI3
peptidyl arginine deiminase, type III
chr2_+_228678550 2.641 ENST00000409189.3
ENST00000358813.4
 CCL20

chemokine (C-C motif) ligand 20

chr11_-_89653576 2.589 ENST00000420869.1
 TRIM49D1
tripartite motif containing 49D1
chr17_-_39553844 2.286 ENST00000251645.2
 KRT31
keratin 31
chr6_-_150346607 2.248 ENST00000367341.1
ENST00000286380.2
 RAET1L

retinoic acid early transcript 1L

chr8_-_91095099 2.165 ENST00000265431.3
 CALB1
calbindin 1, 28kDa
chr2_+_234600253 2.149 ENST00000373424.1
ENST00000441351.1
 UGT1A6

UDP glucuronosyltransferase 1 family, polypeptide A6

chr8_-_125577940 2.027 ENST00000519168.1
ENST00000395508.2
 MTSS1

metastasis suppressor 1

chr21_+_30502806 1.958 ENST00000399928.1
ENST00000399926.1
 MAP3K7CL

MAP3K7 C-terminal like

chr15_-_80263506 1.878 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr7_-_93520259 1.725 ENST00000222543.5
 TFPI2
tissue factor pathway inhibitor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 21.1 GO:0016540 protein autoprocessing(GO:0016540)
0.1 8.4 GO:0018149 peptide cross-linking(GO:0018149)
0.2 5.3 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.1 3.3 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.8 3.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 3.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.5 2.7 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 2.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.9 2.6 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 2.4 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 2.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 2.3 GO:0070268 cornification(GO:0070268)
0.2 2.2 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.1 2.2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 2.2 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 2.1 GO:0007566 embryo implantation(GO:0007566)
0.3 2.0 GO:0030035 microspike assembly(GO:0030035)
0.1 1.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 1.7 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.3 1.5 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 23.3 GO:0030141 secretory granule(GO:0030141)
0.1 8.4 GO:0001533 cornified envelope(GO:0001533)
0.0 3.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.0 2.9 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 2.6 GO:0030018 Z disc(GO:0030018)
0.0 2.2 GO:0043195 terminal bouton(GO:0043195)
0.2 1.5 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.0 1.5 GO:0005882 intermediate filament(GO:0005882)
0.1 1.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1 1.3 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.1 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 1.1 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.8 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 7.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 5.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 2.9 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 2.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.5 2.7 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.1 2.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.9 2.6 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 2.4 GO:0001972 retinoic acid binding(GO:0001972)
0.4 2.2 GO:0005499 vitamin D binding(GO:0005499)
0.2 2.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 2.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 2.1 GO:0051015 actin filament binding(GO:0051015)
0.0 2.0 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.9 GO:0051400 BH domain binding(GO:0051400)
0.1 1.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.5 GO:0008430 selenium binding(GO:0008430)
0.0 1.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.5 1.4 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 1.4 GO:0097200 death receptor binding(GO:0005123) cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 21.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 5.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.2 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.9 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.4 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.9 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.5 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 2.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.9 REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 1.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 1.4 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.4 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.4 REACTOME_REGULATION_OF_APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 1.3 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.0 1.2 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.2 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.1 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 1.0 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 1.0 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 1.0 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.9 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.8 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors