Motif ID: E2F3

Z-value: 1.336


Transcription factors associated with E2F3:

Gene SymbolEntrez IDGene Name
E2F3 ENSG00000112242.10 E2F3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F3hg19_v2_chr6_+_20403997_20404034-0.193.6e-01Click!


Activity profile for motif E2F3.

activity profile for motif E2F3


Sorted Z-values histogram for motif E2F3

Sorted Z-values for motif E2F3



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_67465016 4.250 ENST00000326152.5
 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr21_+_42688686 4.130 ENST00000398652.3
ENST00000398647.3
 FAM3B

family with sequence similarity 3, member B

chr21_+_42688657 4.020 ENST00000357985.2
 FAM3B
family with sequence similarity 3, member B
chr6_+_116937636 3.969 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
 RSPH4A


radial spoke head 4 homolog A (Chlamydomonas)


chr6_+_163148973 3.171 ENST00000366888.2
 PACRG
PARK2 co-regulated
chr6_-_132272504 2.951 ENST00000367976.3
 CTGF
connective tissue growth factor
chr1_-_109655377 2.911 ENST00000369948.3
 C1orf194
chromosome 1 open reading frame 194
chr16_+_80574854 2.909 ENST00000305904.6
ENST00000568035.1
 DYNLRB2

dynein, light chain, roadblock-type 2

chr15_-_68497657 2.817 ENST00000448060.2
ENST00000467889.1
 CALML4

calmodulin-like 4

chr15_-_56757329 2.816 ENST00000260453.3
 MNS1
meiosis-specific nuclear structural 1
chr9_-_99381660 2.723 ENST00000375240.3
ENST00000463569.1
 CDC14B

cell division cycle 14B

chr6_+_33048222 2.686 ENST00000428835.1
 HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr22_+_29279552 2.624 ENST00000544604.2
 ZNRF3
zinc and ring finger 3
chr16_+_58283814 2.542 ENST00000443128.2
ENST00000219299.4
 CCDC113

coiled-coil domain containing 113

chr14_+_75536335 2.300 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
 ZC2HC1C



zinc finger, C2HC-type containing 1C



chr1_-_159869912 2.283 ENST00000368099.4
 CCDC19
coiled-coil domain containing 19
chrX_-_99665262 2.253 ENST00000373034.4
ENST00000255531.7
 PCDH19

protocadherin 19

chr10_+_22634384 2.193 ENST00000376624.3
ENST00000376603.2
ENST00000376601.1
ENST00000538630.1
ENST00000456231.2
ENST00000313311.6
ENST00000435326.1
 SPAG6






sperm associated antigen 6






chr7_+_23719749 2.189 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
 FAM221A



family with sequence similarity 221, member A



chr9_-_138393580 2.164 ENST00000371791.1
 C9orf116
chromosome 9 open reading frame 116

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 525 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.1 GO:0042073 intraciliary transport(GO:0042073)
0.2 4.7 GO:0070986 left/right axis specification(GO:0070986)
0.1 4.3 GO:0003341 cilium movement(GO:0003341)
0.2 4.2 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.0 4.1 GO:0007286 spermatid development(GO:0007286)
1.0 3.9 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.2 3.8 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.3 3.7 GO:0006108 malate metabolic process(GO:0006108)
0.0 3.7 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 3.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.2 3.5 GO:0034059 response to anoxia(GO:0034059)
0.2 3.4 GO:0021670 lateral ventricle development(GO:0021670)
0.0 3.3 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.6 3.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.2 3.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 3.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.7 3.0 GO:0060830 intraciliary anterograde transport(GO:0035720) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.2 3.0 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.7 2.9 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.2 2.8 GO:0070314 G1 to G0 transition(GO:0070314)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 216 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
1.3 6.6 GO:0005879 axonemal microtubule(GO:0005879)
0.5 5.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.2 5.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 4.4 GO:0036064 ciliary basal body(GO:0036064)
0.1 4.3 GO:0030992 intraciliary transport particle B(GO:0030992)
1.3 4.0 GO:0001534 radial spoke(GO:0001534)
0.3 3.8 GO:0036157 outer dynein arm(GO:0036157)
0.0 3.8 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.1 3.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 3.1 GO:0016592 mediator complex(GO:0016592)
0.3 3.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 2.6 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 2.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 2.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 2.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3 2.0 GO:0000408 EKC/KEOPS complex(GO:0000408)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 356 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0005125 cytokine activity(GO:0005125)
0.2 4.6 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 4.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
1.4 4.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.5 3.7 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 3.7 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 3.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 3.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 3.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 3.1 GO:0042605 peptide antigen binding(GO:0042605)
0.9 2.7 GO:0031862 prostanoid receptor binding(GO:0031862)
0.0 2.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.5 2.5 GO:0004306 ethanolamine-phosphate cytidylyltransferase activity(GO:0004306)
0.2 2.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 2.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.4 2.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 2.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 2.2 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 2.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 4.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.0 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 3.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 3.4 PID_E2F_PATHWAY E2F transcription factor network
0.0 3.2 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 3.1 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 2.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.1 PID_MYC_PATHWAY C-MYC pathway
0.0 1.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.4 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 1.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 1.0 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.5 0.5 ST_JAK_STAT_PATHWAY Jak-STAT Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.8 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 4.3 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 4.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 3.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 2.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.5 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 2.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 2.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 2.2 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 2.2 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.0 2.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 2.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.8 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.7 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation