Motif ID: E2F4
Z-value: 0.981
Transcription factors associated with E2F4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2F4 | ENSG00000205250.4 | E2F4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F4 | hg19_v2_chr16_+_67226019_67226127 | -0.04 | 8.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.2 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 0.7 | 2.0 | GO:0070512 | regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512) |
| 0.7 | 1.3 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.6 | 4.7 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.6 | 1.7 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
| 0.4 | 1.7 | GO:0046125 | thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125) |
| 0.3 | 1.0 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 0.3 | 2.0 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.3 | 2.0 | GO:0072757 | cellular response to camptothecin(GO:0072757) |
| 0.3 | 1.0 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.3 | 2.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.3 | 0.8 | GO:0046081 | dUTP metabolic process(GO:0046080) dUTP catabolic process(GO:0046081) |
| 0.3 | 1.8 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.2 | 1.4 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.2 | 1.1 | GO:0071460 | cellular response to cell-matrix adhesion(GO:0071460) |
| 0.2 | 0.6 | GO:0060380 | regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) |
| 0.2 | 0.9 | GO:0072719 | cellular response to cisplatin(GO:0072719) |
| 0.2 | 0.5 | GO:1904899 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.2 | 1.0 | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
| 0.2 | 0.8 | GO:0097021 | Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021) |
| 0.2 | 0.8 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.2 | 0.8 | GO:0046601 | positive regulation of centriole replication(GO:0046601) |
| 0.1 | 1.4 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.1 | 1.4 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.1 | 0.7 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
| 0.1 | 0.4 | GO:0071139 | resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140) |
| 0.1 | 0.6 | GO:0010520 | regulation of reciprocal meiotic recombination(GO:0010520) |
| 0.1 | 0.3 | GO:0046167 | glycerol-3-phosphate biosynthetic process(GO:0046167) |
| 0.1 | 1.1 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.1 | 0.3 | GO:1901069 | guanosine-containing compound catabolic process(GO:1901069) |
| 0.1 | 0.8 | GO:0000710 | meiotic mismatch repair(GO:0000710) |
| 0.1 | 0.4 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 0.1 | 0.3 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
| 0.1 | 1.0 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.1 | 0.4 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
| 0.1 | 3.6 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 2.6 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.1 | 0.7 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.1 | 0.6 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.1 | 0.3 | GO:0006174 | dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571) |
| 0.1 | 1.1 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.1 | 0.2 | GO:0051758 | homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758) |
| 0.1 | 0.1 | GO:0032240 | negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.1 | 0.4 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
| 0.1 | 0.4 | GO:1900454 | positive regulation of long term synaptic depression(GO:1900454) |
| 0.1 | 0.5 | GO:0033504 | floor plate development(GO:0033504) |
| 0.1 | 0.2 | GO:0006424 | glutamyl-tRNA aminoacylation(GO:0006424) |
| 0.1 | 0.4 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
| 0.1 | 2.6 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 0.4 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.1 | 0.6 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.1 | 0.7 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 0.4 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 0.3 | GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973) |
| 0.1 | 0.8 | GO:0009650 | UV protection(GO:0009650) |
| 0.1 | 0.2 | GO:0007037 | vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830) |
| 0.1 | 0.3 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) |
| 0.0 | 0.2 | GO:0010825 | positive regulation of centrosome duplication(GO:0010825) |
| 0.0 | 0.5 | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) |
| 0.0 | 0.5 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.0 | 0.5 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.0 | 0.4 | GO:0045144 | meiotic sister chromatid segregation(GO:0045144) |
| 0.0 | 0.2 | GO:0050976 | detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) |
| 0.0 | 0.7 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.0 | 0.3 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.0 | 0.3 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.0 | 0.2 | GO:0002501 | peptide antigen assembly with MHC protein complex(GO:0002501) |
| 0.0 | 0.3 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
| 0.0 | 0.1 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.0 | 0.1 | GO:0044205 | 'de novo' UMP biosynthetic process(GO:0044205) |
| 0.0 | 1.1 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.0 | 0.1 | GO:0045082 | positive regulation of interleukin-10 biosynthetic process(GO:0045082) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
| 0.0 | 0.5 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 0.2 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 0.0 | 0.1 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.0 | 0.3 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.0 | 0.7 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.0 | 0.1 | GO:0042137 | sequestering of neurotransmitter(GO:0042137) |
| 0.0 | 0.1 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.0 | 0.2 | GO:0039663 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.0 | 0.1 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.0 | 0.4 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 0.1 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
| 0.0 | 0.2 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 0.1 | GO:1904978 | regulation of endosome organization(GO:1904978) |
| 0.0 | 0.1 | GO:0006423 | cysteinyl-tRNA aminoacylation(GO:0006423) |
| 0.0 | 0.2 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.0 | 0.0 | GO:0097116 | postsynaptic density assembly(GO:0097107) gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.0 | 0.3 | GO:0044351 | macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385) |
| 0.0 | 0.2 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 0.3 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.1 | GO:0060148 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.0 | 0.6 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.0 | 0.1 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.0 | 1.0 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
| 0.0 | 0.1 | GO:0003169 | coronary vein morphogenesis(GO:0003169) regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572) |
| 0.0 | 0.1 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.0 | 0.6 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.0 | 0.8 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.0 | 0.1 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.0 | 0.7 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.0 | 0.2 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.0 | 0.2 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
| 0.0 | 1.4 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.0 | 0.3 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.8 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.0 | 0.2 | GO:0000732 | strand displacement(GO:0000732) |
| 0.0 | 0.2 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 0.0 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 0.0 | 0.0 | GO:0044691 | tooth eruption(GO:0044691) |
| 0.0 | 0.0 | GO:0021526 | medial motor column neuron differentiation(GO:0021526) |
| 0.0 | 0.9 | GO:0051310 | metaphase plate congression(GO:0051310) |
| 0.0 | 0.1 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.0 | 0.0 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 0.5 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.0 | 0.1 | GO:0009233 | menaquinone metabolic process(GO:0009233) |
| 0.0 | 0.1 | GO:0016925 | protein sumoylation(GO:0016925) |
| 0.0 | 0.0 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.0 | 0.2 | GO:0010212 | response to ionizing radiation(GO:0010212) |
| 0.0 | 0.3 | GO:0051968 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) |
| 0.0 | 0.2 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.0 | 0.7 | GO:0043525 | positive regulation of neuron apoptotic process(GO:0043525) |
| 0.0 | 0.2 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.1 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.0 | 0.1 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.0 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
| 0.4 | 1.2 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 0.4 | 1.5 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.4 | 1.9 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.3 | 1.2 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 0.3 | 0.9 | GO:0031523 | Myb complex(GO:0031523) |
| 0.2 | 1.4 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.2 | 1.8 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.2 | 2.8 | GO:0042555 | MCM complex(GO:0042555) |
| 0.2 | 1.0 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.2 | 2.2 | GO:0000800 | lateral element(GO:0000800) |
| 0.2 | 0.8 | GO:0098536 | deuterosome(GO:0098536) |
| 0.1 | 2.0 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 1.3 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.1 | 2.1 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.1 | 0.4 | GO:0000939 | condensed chromosome inner kinetochore(GO:0000939) |
| 0.1 | 1.7 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.1 | 1.2 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.1 | 1.2 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.1 | 0.4 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.1 | 0.2 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.1 | 0.7 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 0.1 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 0.1 | 0.3 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.1 | 3.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 1.0 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.3 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 0.6 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 0.1 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.0 | 0.7 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 1.1 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.7 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.5 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 0.1 | GO:0042025 | host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
| 0.0 | 0.3 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 0.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 0.4 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 0.2 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.0 | 0.2 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.0 | 0.2 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.0 | 0.1 | GO:0044609 | DBIRD complex(GO:0044609) |
| 0.0 | 2.8 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 0.2 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 0.5 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 0.2 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 2.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.3 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 0.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.2 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 0.0 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.0 | 0.1 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.0 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.0 | 0.8 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 0.1 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.0 | 0.2 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 1.4 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.2 | GO:0033270 | paranode region of axon(GO:0033270) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:0004797 | thymidine kinase activity(GO:0004797) |
| 0.4 | 1.9 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.3 | 1.4 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.3 | 3.1 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.3 | 1.2 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.3 | 2.3 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 0.3 | 0.8 | GO:0004170 | dUTP diphosphatase activity(GO:0004170) |
| 0.2 | 3.4 | GO:0043142 | single-stranded DNA-dependent ATPase activity(GO:0043142) |
| 0.2 | 0.8 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.2 | 0.6 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.2 | 0.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.2 | 0.9 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
| 0.2 | 1.0 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.1 | 1.1 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.1 | 0.7 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.1 | 0.3 | GO:0004370 | glycerol kinase activity(GO:0004370) |
| 0.1 | 0.3 | GO:0050421 | cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809) |
| 0.1 | 0.5 | GO:0030151 | molybdenum ion binding(GO:0030151) |
| 0.1 | 0.7 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.1 | 0.8 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.1 | 1.0 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 1.2 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.1 | 0.2 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 2.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 0.4 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 0.2 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.1 | 0.3 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.1 | 0.2 | GO:0004818 | glutamate-tRNA ligase activity(GO:0004818) |
| 0.1 | 1.1 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.1 | 0.3 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.1 | 0.2 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) |
| 0.1 | 0.2 | GO:0030626 | U12 snRNA binding(GO:0030626) |
| 0.0 | 1.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 3.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 3.4 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.7 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 0.3 | GO:0016416 | O-palmitoyltransferase activity(GO:0016416) |
| 0.0 | 0.5 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.3 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 0.0 | 0.2 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.0 | 0.1 | GO:0004087 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 0.0 | 1.0 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 0.4 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.0 | 0.5 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 0.3 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.0 | 0.8 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.1 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.0 | 0.3 | GO:0050145 | nucleoside phosphate kinase activity(GO:0050145) |
| 0.0 | 0.2 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.7 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.0 | 0.2 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
| 0.0 | 0.1 | GO:0086089 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089) |
| 0.0 | 0.1 | GO:0004817 | cysteine-tRNA ligase activity(GO:0004817) |
| 0.0 | 0.6 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.1 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858) |
| 0.0 | 0.3 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.0 | 0.1 | GO:0070717 | poly-purine tract binding(GO:0070717) |
| 0.0 | 0.2 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 0.0 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.0 | 0.1 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.0 | 0.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.4 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.3 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.0 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.0 | 0.0 | GO:0008940 | nitrate reductase activity(GO:0008940) molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599) |
| 0.0 | 0.2 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 0.9 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.2 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 0.1 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.0 | 0.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 0.1 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.0 | 0.3 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.5 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.0 | 0.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.8 | GO:0005044 | scavenger receptor activity(GO:0005044) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.8 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 5.5 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 0.9 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 2.0 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 1.2 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.8 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 0.5 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.0 | 2.1 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.5 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.1 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.0 | 2.4 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 0.2 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 0.4 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.3 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.4 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.3 | 5.8 | REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.2 | 7.6 | REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.2 | 3.4 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.2 | 3.0 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.1 | 2.4 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 2.6 | REACTOME_PYRIMIDINE_METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 1.6 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 0.5 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 1.1 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.2 | REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION | Genes involved in Binding and entry of HIV virion |
| 0.0 | 4.2 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 2.3 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.3 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.7 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.7 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.6 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.5 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.4 | REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 0.0 | 0.2 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.7 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.4 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.3 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.3 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.2 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.7 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
