Motif ID: E2F4

Z-value: 0.981


Transcription factors associated with E2F4:

Gene SymbolEntrez IDGene Name
E2F4 ENSG00000205250.4 E2F4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F4hg19_v2_chr16_+_67226019_67226127-0.048.4e-01Click!


Activity profile for motif E2F4.

activity profile for motif E2F4


Sorted Z-values histogram for motif E2F4

Sorted Z-values for motif E2F4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_22737678 2.368 ENST00000382772.3
 EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr14_-_55658323 2.029 ENST00000554067.1
ENST00000247191.2
 DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chrY_+_22737604 1.970 ENST00000361365.2
 EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr2_+_10262857 1.853 ENST00000304567.5
 RRM2
ribonucleotide reductase M2
chr1_+_91966656 1.745 ENST00000428239.1
ENST00000426137.1
 CDC7

cell division cycle 7

chr1_+_91966384 1.741 ENST00000430031.2
ENST00000234626.6
 CDC7

cell division cycle 7

chr17_-_76183111 1.703 ENST00000405273.1
ENST00000590862.1
ENST00000590430.1
ENST00000586613.1
 TK1



thymidine kinase 1, soluble



chr19_-_48673580 1.581 ENST00000427526.2
 LIG1
ligase I, DNA, ATP-dependent
chr19_-_48673552 1.554 ENST00000536218.1
ENST00000596549.1
 LIG1

ligase I, DNA, ATP-dependent

chr12_-_77459306 1.536 ENST00000547316.1
ENST00000416496.2
ENST00000550669.1
ENST00000322886.7
 E2F7



E2F transcription factor 7



chr8_-_95907423 1.517 ENST00000396133.3
ENST00000308108.4
 CCNE2

cyclin E2

chr15_+_91260552 1.477 ENST00000355112.3
ENST00000560509.1
 BLM

Bloom syndrome, RecQ helicase-like

chr5_+_892745 1.401 ENST00000166345.3
 TRIP13
thyroid hormone receptor interactor 13
chr11_-_64851496 1.301 ENST00000404147.3
ENST00000275517.3
 CDCA5

cell division cycle associated 5

chr22_+_19467261 1.183 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
 CDC45



cell division cycle 45



chr7_-_21985489 1.178 ENST00000356195.5
ENST00000447180.1
ENST00000373934.4
ENST00000457951.1
 CDCA7L



cell division cycle associated 7-like



chr6_+_126661253 1.159 ENST00000368326.1
ENST00000368325.1
ENST00000368328.4
 CENPW


centromere protein W


chr5_-_127873659 1.108 ENST00000262464.4
 FBN2
fibrillin 2
chr10_-_70231639 1.081 ENST00000551118.2
ENST00000358410.3
ENST00000399180.2
ENST00000399179.2
 DNA2



DNA replication helicase/nuclease 2



chr4_-_185655278 1.049 ENST00000281453.5
 MLF1IP
centromere protein U

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.7 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.8 4.2 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.1 3.6 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.3 2.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 2.6 GO:0051290 protein heterotetramerization(GO:0051290)
0.1 2.6 GO:0006270 DNA replication initiation(GO:0006270)
0.7 2.0 GO:0070512 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.3 2.0 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.3 2.0 GO:0072757 cellular response to camptothecin(GO:0072757)
0.3 1.8 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.6 1.7 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.4 1.7 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.2 1.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 1.4 GO:0007144 female meiosis I(GO:0007144)
0.1 1.4 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 1.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.7 1.3 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.2 1.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.1 1.1 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 1.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.9 GO:0001650 fibrillar center(GO:0001650)
0.2 2.8 GO:0042555 MCM complex(GO:0042555)
0.0 2.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.2 2.2 GO:0000800 lateral element(GO:0000800)
0.1 2.1 GO:0001673 male germ cell nucleus(GO:0001673)
0.5 2.0 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.1 2.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 1.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 1.8 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.7 GO:0042575 DNA polymerase complex(GO:0042575)
0.4 1.5 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 1.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 1.4 GO:0005814 centriole(GO:0005814)
0.1 1.3 GO:0008278 cohesin complex(GO:0008278)
0.4 1.2 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.3 1.2 GO:0032301 MutSalpha complex(GO:0032301)
0.1 1.2 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 1.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 3.4 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 3.4 GO:0003684 damaged DNA binding(GO:0003684)
0.3 3.1 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.1 2.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 2.3 GO:0000405 bubble DNA binding(GO:0000405)
0.4 1.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.6 1.7 GO:0004797 thymidine kinase activity(GO:0004797)
0.0 1.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 1.4 GO:0003896 DNA primase activity(GO:0003896)
0.3 1.2 GO:0032143 single thymine insertion binding(GO:0032143)
0.1 1.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 1.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 1.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.2 1.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 1.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 0.9 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.9 GO:0003682 chromatin binding(GO:0003682)
0.3 0.8 GO:0004170 dUTP diphosphatase activity(GO:0004170)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 5.5 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 2.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 2.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.2 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.3 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.1 ST_JAK_STAT_PATHWAY Jak-STAT Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.6 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.3 5.8 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.0 4.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 3.4 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 3.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.6 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.3 2.4 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 2.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.6 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.4 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 1.1 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis